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ProteomicsOn-bead vs FASP vs InGel sample preparation for LC-MS/MS
The aim of this project was to compare and optimize sample processing protocols up-stream of LC-MS/MS. We set out to create a protocol that is easier and less laborious to use with liquid handlers than FASP, but that generates comparable results as FASP or traditional in-gel digestion.
ORGANISM(S): Homo sapiens (Human) 
2018-07-19 | PXD005944 | Pride
On-bead digestion Gelfree Fasp Lc-ms/ms 
ProteomicsA proteomic map of the human aqueous humor
The aqueous humor is a colourless, transparent fluid that fills the anterior chamber of the eye. It has an important role to play in maintaining the intraocular pressure of the eye and providing nourishment to avascular structures such as the lens and cornea. It is also essential for providing a cle...
ORGANISM(S): Homo sapiens (Human) 
2016-01-04 | PXD000787 | Pride
Human Brplc Aqueous humor Trypsin Scx Humor Ingel Eye Lc-ms/ms 
ProteomicsA small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis
Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control mechanism that also regulates lipid metabolism and calcium homeostasis. Dysregulation of ERAD and unfolded protein response underlies diseases including cancer, neurodegenerative disorders, and metabolic syndro...
ORGANISM(S): Homo sapiens (Human) 
2026-01-20 | PXD071546 | Pride
Erad Proteomics Ingel digestion Er-phagy Vdac 
ProteomicsRat spleen proteomics profiling
Sample preparation optimisation for extracting in a quantitative manner proteins from rat spleen
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-04 | PXD003520 | Pride
Rat Quantitative proteomics Spleen 
Proteomicsrat serum exosomes after restriction stress
The project investigates the occurrence of brain derived proteins as biomarkers for restriction oder immobilisations stress.
ORGANISM(S): Rattus norvegicus (Rat) 
2018-12-21 | PXD009085 | Pride
Rat Exosomes Stress 
ProteomicsProtein identification in mouse liver by LC-MSMS
To identify TJP1-interacting proteins in primary hepatocytes cultured in collagen sandwich configuration (SD+) in vitro
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD016917 | Pride
Mouse Liver Hepatocytes Lc-msms 
ProteomicsA proteomic map of the human aqueous humor
The aqueous humor is a colourless, transparent fluid that fills the anterior chamber of the eye. It has an important role to play in maintaining the intraocular pressure of the eye and providing nourishment to avascular structures such as the lens and cornea. It is also essential for providing a cle...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-29 | MSV000081764 | MassIVE
ProteomicsThe cleavage site identification of Gm11437 by LC-MSMS
This study first identified the gut-derived factor Famsin, which is the N-terminal cleavage product of the single-transmembrane protein Gm11437, revealed a new liver-gut signaling axes involved in the regulation of energy homeostasis
ORGANISM(S): Mus musculus (Mouse) 
2023-03-21 | PXD024577 | Pride
To determine the amino acid sequence of gm11437 n-terminal product purified from sf9 conditional medium 
ProteomicsDiscovery of dedicated EPHA2 inhibitors - Medicinal chemistry meets chemical proteomics
The receptor tyrosine kinase EPHA2 has gained interest as therapeutical drug target in cancer and infectious diseases in the past years. However, EPHA2 research and EPHA2 based therapies have been hampered by the lack of selective small molecule EPHA2 inhibitors. We report on the synthesis and evalu...
ORGANISM(S): Homo sapiens (Human) 
2017-05-30 | PXD006193 | Pride
Eph receptor Drug discovery Selectivity profiling Inhibitors Chemical proteomics 
ProteomicsChemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors
Protein kinases are key components in signal transduction pathways and are established drug targets in oncology. Consequently, small molecule kinase inhibitors are on the rise but often show a rather broad target spectrum, potentially leading to toxic side effects. As a result, a broad assessment of...
ORGANISM(S): Homo sapiens (Human) 
2017-03-22 | PXD003373 | Pride
Kinase inhibitor Fech Photosensitivity Chemical proteomics Ferrochelatase Vemurafenib Kinobeads 
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