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ProteomicsCysteine-targeted proteomics analysis
The protein cysteine residue is one of the amino acids most susceptible to oxidative modifications, frequently caused by oxidative stress. Several applications have enabled cysteine-targeted proteomics analysis with simultaneous detection and quantitation. In this study, we employed a quantitative a...
ORGANISM(S): Homo sapiens (Human) 
2016-07-18 | PXD004303 | Pride
Hek293t Iodotmt6plex 
ProteomicsBrevetoxin induces a shift in the redox state of the proteome and unfolded protein response in human lymphoblast cells that can be alleviated with the acrolein scavenger MESNA
Human lymphoblast cells (GM05581) were treated with (i) brevetoxin-2 (5 uM) or (ii) a combination of brevetoxin-2 (5 uM) and sodium 2-mercaptoethyl sulfonic acid (500 uM) or (iii) equal volume of vehicle (DMSO, control) for 24 h. Each sample is an iodoTMT6plex with 2 replicates of each of the a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090293 | MassIVE
UnknownIdentification and Quantification of S-Sulfenylation Proteome of Mycobacterium tuberculosis under Oxidative Stress.
Not available
S-EPMC10101118 | biostudies-literature
ProteomicsMycobacterium tuberculosis modified proteome under oxidative stress
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), continues to be a public health threat. With the development and widespread of drug-resistant TB, the pressure of prevention and treatment is increasing. To determine and quantify the modified proteins, high resolution mass spec...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2023-03-09 | PXD035802 | Pride
Mycobacterium tuberculosis Oxidative stress Proteome 
ProteomicsPeripubertal Bisphenol A Exposure Imparts Detrimental Acute and Aging-Related Changes in Body Composition, Cognition, and H2S Production and Signaling
Peripubertal endocrine disruption has immediate and lifelong consequences on health, cognition, and lifespan. Disruption comes from dietary, environmental, and pharmaceutical sources. The plasticizer Bisphenol A (BPA) is one such endocrine disrupting chemical (EDC). However, it’s unclear if peripube...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-25 | PXD025746 | Pride
Endocrine disruption Bisphenol a (bpa) Cognition H2s Peripubertal Persulfidation Aging 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022888 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsRedox-dependent protein S-glutathionylation governs azacitidine sensitivity and resistance in AML
Hypomethylation therapy significantly prolongs survival of patients with high-risk myelodysplastic syndrome progressing to acute myeloid leukaemia, yet most patients develop resistance. In this work we identified redox-regulated mechanisms of hypomethylation therapy and revealed that in resistant ce...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD056452 | Pride
ProteomicsOrphan precursor proteins and ROS activate the mitochondrial UPR_Redox proteomics
The mitochondrial unfolded protein response (UPRmt) safeguards mitochondria from proteotoxic damage by activating a dedicated transcriptional response in the nucleus to restore proteostasis. How the mitochondrial protein misfolding information is signalled to the nucleus as part of the human UPRmt r...
ORGANISM(S): Homo sapiens (Human) 
2023-05-19 | PXD032011 | Pride
Uprmt Proteomics Iodotmt Ros Mitochondria Redox 
ProteomicsProteome-wide detection of cysteine nitrosylation targets and motifs using bio-orthogonal cleavable linker based enrichment and switch technique (Cys-BOOST)
Cysteine (Cys) reversible post-translational modifications (PTMs) are emerging as important players in cellular signaling and redox homeostasis. Here we present Cys-BOOST a novel strategy for LC-MS/MS based quantitative analysis of reversibly modified Cys using switch technique, enrichment via bio-o...
ORGANISM(S): Homo sapiens (Human) 
2019-05-21 | PXD011131 | Pride
Cysteine Nitrosylation Ptm 
ProteomicsCharacterization of the redox proteome in Drosophila melanogaster aging eyes.
During oxidative stress, reactive oxygen species (ROS) can modify and damage cellular proteins. In particular, the thiol groups of cysteine residues can undergo reversible or irreversible oxidative post-translation modifications (PTMs). Identifying the redox-sensitive cysteines on a proteome-wide sc...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-04-27 | PXD036110 | Pride
Drosophila eye Oxidative post-translation modifications Redox proteome Aging 
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