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ProteomicsA chemoproteomics approach to discover regulators of innate immune signaling
Viral dsRNA binds to Retinoic acid Inducible Gene I (RIG-I) Like Receptors (RLRs), promoting the production of Interferon (IFN). Interferon then stimulates the innate and adaptive immune system in an autocrine and paracrine manner. Outside of conical pathways, regulators of the interferon (IFN) acti...
ORGANISM(S): Homo sapiens (Human) 
2023-06-02 | PXD041369 | Pride
Atr Atm Interferon Ampk Signaling pathways Proteomics  phosphoproteomics Kinases Plk1 Rig-i 
ProteomicsSARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication
SARS-CoV-2, the causative agent of the COVID-19 pandemic, drastically modifies infected cells in an effort to optimize virus replication. Included in this process is the activation of the host p38 mitogen-activated protein kinase (MAPK) pathway, which plays a major role in inflammation and is a cent...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2023-06-01 | PXD035451 | Pride
Betacoronavirus P38 Mapk11 Mapk P38β P38beta Phosphoproteomics N Nucleocapsid Sars-cov-2 Proteomics Coronavirus Covid-19 
ProteomicsGlobal post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling
Viruses must effectively remodel host cellular pathways to replicate and evade immune defenses, and they must do so with limited genomic coding capacity. Targeting post-translational modification (PTM) pathways provides a mechanism by which viruses can broadly and rapidly transform a hostile host en...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD032085 | Pride
Hiv-1 Proteomics Vif B56 Ubiquitination Vpr Pp2a Phosphorylation Histone h1 Systems biology 
ProteomicsImmunological landscape of human lymphoid explants during measles virus infection
In humans, lymph nodes are the primary site of measles virus (MeV) replication. To understand the immunological events that occur at this site, we infected human lymphoid tissue explants using a pathogenic strain of MeV that expresses GFP. We found that MeV infected between 5-15% of cells across don...
ORGANISM(S): Homo sapiens (Human) 
2024-09-10 | PXD054861 | Pride
Lymph node Measles virus 
ProteomicsQuantitative tissue proteomics reveals increased pathogenesis associated with infection with the SARS-CoV-2 Delta variant that is independent of viral infectivity in Syrian golden hamsters
Background: Since its emergence in 2020, circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been dominated by waves of genetically distinct variants with varying pathogenicity. Understanding the molecular mechanisms underlying SARS-CoV-2 pathogenesis, and the host and viral...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2026-01-26 | PXD054808 | Pride
Sars-cov-2 Proteomics Hamster Phosphoproteomics Pathogenesis 
ProteomicsImmunization of mice with virus-like vesicles of Kaposi sarcoma-associated herpesvirus reveals a role of ORF4 in complement-mediated neutralization
The development of a prophylactic vaccine for Kaposi sarcoma-associated Herpesvirus (KSHV) would prevent consequences from infection including disorders such as Kaposi sarcoma and primary effusion lymphoma. Here, we study the immunogenicity of noninfectious virus-like vesicles (VLVs) of KSHV as a po...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2023-02-01 | PXD035478 | Pride
Kshv herpesvirus 
ProteomicsAn Integrated Proteomics Approach Identifies Phosphorylation Sites on Host and Viral Proteins that Regulate West Nile Virus Infection
Upon infection, viruses remodel host cells to create an environment hospitable to viral replication. In response, host cells have evolved to sense infection and rapidly induce pathways to limit viral replication. One strategy used by both players is to regulate the host cell proteome for their benef...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD050159 | Pride
Wnv West nile virus Flavivirus 
ProteomicsThe EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization
Persistent HIV reservoirs in CD4⁺ T-cells impede efforts to cure HIV infection. We identified overexpression of enhancer of zeste homolog 2 (EZH2) in HIV-infected CD4⁺ T-cells that survive cytotoxic T lymphocyte (CTL) exposure, suggesting a mechanism of CTL resistance. Inhibition of EZH2 with the FD...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD061146 | Pride
Hiv Cd8 t cells Ezh2 Tazemetostat 
ProteomicsEvidence for a unique RNA motif in orchestrating 2 Orthomyxoviridae splicing
Despite lacking a DNA intermediate, orthomyxoviruses complete their replication cycle in the nucleus and generate multiple transcripts through noncanonical splicing. This biology enables the slow accumulation of a subset of viral transcripts which serve as a timer to coordinate the later phases of t...
ORGANISM(S): Homo sapiens (Human) 
2023-03-14 | PXD033815 | Pride
Orthomyxoviridae L7ae 
ProteomicsDynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis
Chromatin remodeling complexes instruct cellular differentiation and lineage specific transcription. The BRG1/BRM associated factor (BAF) complexes are important for several aspects of differentiation. We show that the catalytic subunit Brg1 has a specific role in cardiac precursors (CPs) to initiat...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-13 | PXD012721 | Pride
Differentiation Gene regulation Heart Chromatin 
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