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MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
ProteomicsGlobal Analyses of Selective Insulin Resitance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
ORGANISM(S): Homo sapiens (Human) 
2018-02-14 | PXD006395 | Pride
Insulin resistance Lipotoxicity Phosphoproteomics Hepatic steatosis 
ProteomicsFitm2 is required for ER homeostasis and normal function of murine liver
The ER-resident prote in fat-inducing transcript 2 (FIT2) catalyzes acyl-CoA cleavage in vitro, and in cells is required for endoplasmic reticulum (ER)homeostasis and normal lipid storage. The gene encoding FIT2 is essential for viability of mice and worms. Whether FIT2 acts as anacyl-CoA diphosphat...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD033884 | Pride
Lipid metabolism Acyl-coa Endoplasmic reticulum Liver Fitm2 
ProteomicsRab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells
Rab GTPases recruit peripheral membrane proteins and can define organelle identity. Rab18 localizes to the ER but also to the surfaces of lipid droplets (LDs), where it has been implicated in effector protein recruitment and in defining LD identity. Here, we studied Rab18 localization and function i...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009683 | Pride
Triacylglycerol Lipid droplet Endoplasmic reticulum Rab18 Neutral lipid storage Rabgtpase 
ProteomicsIdentification of molecular machinery mediating ER to lipid droplet protein targeting
Lipid droplets (LDs) are organelles that store lipids and contain important metabolic proteins at their surfaces. The pathway for membrane-embedded hydrophobic proteins to reach the LD surface from the ER is largely unknown. Here, we find that many proteins, including key lipid synthesis and degrada...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-06-27 | PXD027283 | Pride
Endoplasmic reticulum Protein trafficking Membrane fusion Protein targeting Lipid droplet 
ProteomicsSystematic genome perturbation reveals coordination of lipid droplets and metabolic gene regulation
Lipid droplets (LDs) store lipids for metabolic eneergy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012640 | Pride
Metabolism Chrebp Mlx Mondoa Mondob Transcription facot Mlxipl Lipid droplets Glucose Mlxip 
ProteomicsHepatocyte Deletion of Triglyceride-Synthesis Enzyme DGAT2 Reduces Steatosis without Increasing Inflammation or Fibrosis
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation in hepatocytes and reprepresents a huge public health problem owing to its propensity to progress to non-alcoholic steatohepatitis (NASH), fibrosis, and liver failure. The lipids stored in hepatic steatosis are p...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD013423 | Pride
Triacylglycerol Liver Diacylglycerol Nonalcoholic fatty liver disease Steatohepatitis Dietary lipids 
ProteomicsInhibiting sphingolipid synthesis improves outcomes and survival in GARP-mutant wobbler mouse, an ALS model
Defects of the endosomal and lysosomal systems have been increasingly linked to adult neurodegenerative diseases1,2. Deficiencies in the retrograde trafficking pathway between endosomes and the Golgi apparatus lead to forms of Alzheimer’s and Parkinson’s diseases in the case of retromer mutations, o...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD007981 | Pride
Lc-msms Silac Mef 
ProteomicsCharacterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
Introduction: Ampullary cancer is a relatively rare entity and usually treated by pancreatoduodenectomy followed by adjuvant therapy. The intestinal subtype is associated with markedly improved prognosis after resection. Only few cell lines are available for in vitro studies of ampullary cancer and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080802 | MassIVE
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