Sort   by:  
 Page size 
ProteomicsMicroglial proteomic signatures in APPPS1 and APP-KI mice
Microglial dysfunction is a key pathological feature of Alzheimer´s disease (AD), but little is known about proteome-wide changes in microglia during the course of AD pathogenesis and their consequences for microglial function. Here, we performed an in-depth proteomic characterization of microglia i...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-09 | PXD016075 | Pride
Neuroinflammation Phagocytosis Alzheimer’s disease Proteomic signatures Microglia 
ProteomicsSurface glycoproteome of BACE1-inhibited neurons
The cell surface proteome is dynamic and has fundamental roles in cell signaling. Many surface membrane proteins are proteolytically released into a cell’s secretome, where they can have additional functions in cell-cell-communication. Yet, it remains challenging to determine the surface proteome an...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-08 | PXD008619 | Pride
Bace1 Surface N-glycoproteome Murine neurons 
ProteomicsBeneficial effect of ACI-24 vaccination on microglial phenotypes in an amyloidosis mouse model
Amyloid-beta (Aβ) deposition is an initiating factor in Alzheimer´s disease (AD). Microglia are the brain immune cells that surround and phagocytose Aβ, but their phagocytic capacity declines in AD. This is in agreement with studies that associate AD risk loci with genes regulating phagocytic functi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-09 | PXD038665 | Pride
Alzheimer Vaccination Microglia 
ProteomicsQuantitative proteomics of CSF from the Alzheimer's disease mouse model 5xFAD
The 5xFAD mouse model was used to study the influence of amyloid pathology on the cerebrospinal fluid (CSF) proteome. Therefore, CSF of 7-months old 5xFAD and WT control mice was sampled with an improved collection protocol. Using a minute amount of 5 µL CSF, we applied data dependent and data indep...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-15 | PXD053568 | Pride
Cerebrospinal fluid Dia 5xfad Alzheimer's disease Csf Dda 
ProteomicsGrowth factor-mediated regulation of neuronal exosome release depends on VAMP3/cellubrevin
Extracellular vesicles (EVs) are small membrane-derived vesicles that shuttle proteins or nucleic acids between glia and neurons, thereby promoting neuronal survival and plasticity in the CNS. Exosomes are small EVs (40-150 nm) that are derived from multi-vesicular bodies (MVBs) of the endo-lysosoma...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-02-06 | PXD014401 | Pride
Vamp3 Rat Neurons Exosome 
ProteomicsCSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD032782 | Pride
Cerebrospinal fluid Bace Alzheimer disease Appps1 Csf 
UnknownCationic cluster formation versus disproportionation of low-valent indium and gallium complexes of 2,2'-bipyridine.
Not available
S-EPMC4633986 | biostudies-literature
ProteomicsPerilous Sites: High basic Fibroblast Growth Factor level supplement Parkinson’s disease pathology and its Spread
Lewy body (LB) pathology and loss of dopaminergic neurons are imprints of Parkinson’s disease (PD). LBs are mainly comprised of alpha-Synuclein (Dijkstra et al., 2014). Strolling detection of LBs in brain regions contribute to progressive construct of PD pathology to which molecular mechanisms are n...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-21 | PXD015969 | Pride
Neuron Exosome Bfgf Rat 
ProteomicsMitoproteomics of neuronal mitochondria of EAE mice
Inflammation in the central nervous system (CNS) can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell type-specific mitochondrial proteomics with in vivo biosensor imaging to dissec...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-18 | PXD032363 | Pride
Mitochondria Idh3 Neurons 
ProteomicsSPPL3 cleavage of glycosyltransferases regulates their activity
The GxGD intramembrane-cleaving aspartylprotease signal peptide peptidase-like 3 (SPPL3) is a Golgi-resident, multi-pass membrane protein that is highly conserved among multicellular eukaryotes pointing to a pivotal physiological function in the Golgi network. Recently, the key branching enzyme N-ac...
ORGANISM(S): Homo sapiens (Human) 
2015-05-08 | PXD001672 | Pride
Substrates Protease Specs Sppl3 
Sort   by:  
 Page size