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Proteomicsinvestigation of changes in the proteome and the phosphoproteome of the heart induced by exercise, either in control or in PKP2-deficient hearts in relation to ARVC
We performed an unbiased investigation of changes in the proteome and the phosphoproteome of the heart induced by exercise, either in control or in PKP2-deficient hearts. Two pairs of experimental groups were studied: The first pair consisted of control animals and the second pair of animals deficie...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-04 | PXD025956 | Pride
Mouse Pkp2 Heart failure Cardiovascular Arvc 
ProteomicsPhosphoproteomics evaluation of the effect of GLP-1 on the porcine pacemaker
GLP-1 induces an increase in heart rate, but its mechanism remains elusive. We used a phosphoproteomic approach to evaluate the effect of GLP-1 on the porcine sinus node. Tissue samples from the sinus node region and left ventricle were collected from eight animals following a 60-minute infusion wit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-06-10 | PXD042583 | Pride
Heart Phosphoproteomics Pig Pacemaker Glucagon-like peptide 1 Porcine Glp-1 Sinus node 
ProteomicsAn unbiased molecular characterisation of peripartum cardiomyopathy identfies mast cell chymase as a new diagnostic candidate and therapeutic target
Peripartum cardiomyopathy (PPCM) is a rare form of acute heart failure that develops in women towards the end of pregnancy or early in the postpartum period. Despite clinical similarities to dilated cardiomyopathy of other etiologies (non-peripartum cardiomyopathy; NPCM), the molecular mechanisms dr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD061985 | Pride
Human Heart Cardiomyopathy Peripartum 
ProteomicsBeta-blocker/ACE inhibitor therapy differentially impacts the steady state signaling landscape of failing and non-failing hearts.
Rationale: The molecular underpinnings of heart failure with reduced ejection fraction (HFrEF) involves a complex remodeling of the contractile, metabolic and electrical functions. Current pharmacotherapy for patients presenting HFrEF includes combination of angiotensin-converting enzyme inhibitors ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD024525 | Pride
Ace inhibitor Hfref Cardiac proteomics ß-ar blocker Phosphoproteomics 
ProteomicsThe protein expression landscape of the heart across humans and model organisms
Here we perform a global analysis of cardiac protein expression in humans and model organisms across cardiac chambers using quantitative mass spectrometry based proteomics. We measure >6,500 proteins in each species and create a global comparison of cardiac protein expression across species. The dat...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Homo sapiens (Human) Mus musculus (Mouse) Sus scrofa domesticus (domestic pig) Rattus norvegicus (Rat) Equus caballus (Horse) 
2021-02-03 | PXD012636 | Pride
Lc-ms Proteomics Species Heart Proteomes Cardiac proteomics 
ProteomicsQuantitative proteomics of FFPE-preserved cardiac specimens
Archival human heart tissue, preserved as formalin-fixed, paraffin-embedded (FFPE) samples in pathology collections worldwide, represents a largely untapped resource for cardiac proteomics. This study employs a comprehensive proteomic workflow optimized for human FFPE heart tissue and leverages pair...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD060216 | Pride
Human Ffpe Heart 
ProteomicsQuantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation.
Genetic and genomic research has greatly advanced our understanding of heart disease; yet a comprehensive map of the protein landscape of living human hearts is still lacking. Here we set out to identify the molecular basis of functional differences between human cardiac chambers by comprehensive p...
ORGANISM(S): Homo sapiens (Human) 
2020-06-15 | PXD008722 | Pride
Heart Tissue Hypertrophy Biopsies Mitral valve disease Gwas Dilated cardiomyopathy Human 
ProteomicsQuantitative proteomics profiling determines the uniqueness of the sinus node
The sinus node is a collection of highly specialized cells that constitute the natural pacemaker activity of our heart. The protein expression landscape of the sinus node differs from the surrounding cardiac tissue, although it is primarily comprised of myocytes and fibroblasts like the rest of the ...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-08 | PXD008736 | Pride
Pacemaker Heart Tissue Sinus node Mouse Conduction Lc-ms/ms 
ProteomicsRyR2 phosphorylation profile in PKP2cKO mice
The project aimed to investigate whether there are alterations in the phosphorylation status of the Ryanodine receptor 2 (RyR2) in the left atria of mice with a cardiac-specific knockout of PKP2, compared to wild-type mice.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD052074 | Pride
Mouse Immunoprecipitation Ryr2 Phosphorylation 
ProteomicsIn-depth phosphoproteomic profiling of the insulin signaling response in heart tissue and cardiomyocytes unveils canonical and spezialized regulation
Insulin signaling regulates cardiac substrate utilization and is implicated in physiological adapations of the heart. While extensively investigated in several metabolic organs using phosphoproteomic strategies, the signaling response elicited in cardiac tissue in general, and specifically in the sp...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD050545 | Pride
Phosphoproteomics Heart Insulin Tbc1d4 
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