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ProteomicsProtein Succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity
The cytokines tumor necrosis factor ligand superfamily member 11 (TNFSF11; also known as RANKL) and macrophage colony-stimulating factor 1 receptor (M-CSF) differentiate macrophages into bone-resorbing osteoclasts via a process characterised by changes in metabolic activity that support energy-consu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD060675 | Pride
Succinylation Post translational modification Steoclast Citrate synthase Rankl 
ProteomicsMitochondrial surveillance activates the primary UPRmt
The mitochondrial unfolded protein response (UPRmt) is critical for protecting mitochondria against proteotoxic stress. Current UPRmt models propose that mitochondrial defects are detected by cytosolic surveillance mechanisms after release of damage into the cytosol. However, these findings are base...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-04-20 | PXD077396 | Pride
Reactive oxygen species Presequence processing Mitochondrial protein biogenesis Mitochondrial unfolded protein response 
ProteomicsGlycan-based Biological Degraders Targeting the Cytokine Immune Axis
The project investigates targeted degradation of IL-6 and sIL6-R using bispecific Biological Degraders (BioDegs) that enable receptor-mediated uptake via the asialoglycoprotein receptor (ASGPR). Various IL-6(R)–binding scaffolds were modified with triantennary N-acetylgalactosamine (TGN) to promote ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD075514 | Pride
Asgpr Targeted protein degradation Biological degraders Tri-n-acetylgalactosamine Lysosomal degradation Il-6 Sil-6r 
ProteomicsCRKL enhances YAP signaling through binding and JNK/JUN pathway activation in liver cancer
Hepatocellular carcinoma (HCC) presents a major health issue due to its rising incidence and limited therapeutic options. The Hippo pathway transducers yes-associated protein (YAP) and WW-domain containing transcription regulator 1 (WWTR1/TAZ) are key regulators of liver tu-morigenesis promoting tum...
ORGANISM(S): Homo sapiens (Human) 
2024-11-26 | PXD058235 | Pride
Hcc  hippo  bioid  crk  survival  ap1  tead  proteomics  ms  c-jun 
ProteomicsKaiso as a Novel TAZ Interaction Partner Driving Fibrogenesis in Hepatic stellate cells via regulating the long non-coding RNA HIF1A-AS3
The Hippo pathway effectors yes associated protein (YAP) and transcriptional co activator with PDZ binding motif (TAZ) are key regulators of hepatic stellate cell (HSC) activation and liver fibrosis. While the canonical YAP/TAZ–TEAD transcriptional axis has been extensively characterized, non canoni...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD074737 | Pride
Bioid Taz Mass spectrometry Lx-2 cells Kaiso Proximity labeling Yap Hif1a-as3 Liver fibrosis Hippo pathway Hepatic stellate cells 
ProteomicsSystemic application of IL-4 attenuates secondary local inflammation processes and enhances functional recovery after traumatic spinal cord injury in rats.
Background: Traumatic spinal cord injury (SCI) triggers local and systemic inflammation cascades, limiting neuroregeneration and impeding functional recovery. We investigated the systemic effect of immunomodulation with Interleukin-4 (IL-4) on the local immune reaction and regeneration in injured sp...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-03-16 | PXD065980 | Pride
Immunomodulation Catwalk xt gait analysis Seromics Spinal cord injury Il-4 
ProteomicsTransplantation of LPS, IL-4, and TGF-β-induced unique macrophages promotes recovery of motor function after spinal cord injury in rats
In vitro experiments: Proteomic profiling of bone marrow-derived macrophages following 24-hour stimulation with LPS, IL-4, and TGF-β. In vivo experiments: Proteomic analysis of spinal cord changes following transplantation of bone marrow-derived macrophages induced by LPS, IL-4, and TGF-β in a spina...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-21 | PXD066320 | Pride
Macrophages Spinal cord injury Regeneration Therapy Inflammation 
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
ProteomicsSex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes.
The project investigates how X-linked epigenetic enzyme KDM6A regulates liver cholesterol metabolism and cardiovascular disease risk. We integrate multi-omics data from human liver cell lines and tissue-specific knockout mice to dissect the interplay of transcription factors and coregulators in the ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD074624 | Pride
Liver Atherosclerosis Kdm6a 
ProteomicsAn atypical Arp2/3 complex is required for Plasmodium DNA segregation and transmission of malaria.
Plasmodium parasites, the causative agents of malaria, undergo crucial developments within the mosquito vector, initiated by the formation of male and female gametes from gametocytes. Male gametogenesis involves three rapid rounds of endomitosis followed by a single round of DNA segregation and nucl...
ORGANISM(S): Mus musculus (Mouse) Plasmodium berghei 
2025-04-22 | PXD060997 | Pride
Arp2/3 complex Chromosome segregation Malaria Plasmodium 
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