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MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
ProteomicsThe molecular basis of integrated stress response silencing
Chronic stress response activation impairs cell survival and causes devastating degenerative di-seases. To counteract this, cells deploy dedicated silencing factors, such as the E3 ligase SIFI that terminates the mitochondrial stress response. How a single enzyme can sense stress across cellular sca...
ORGANISM(S): Homo sapiens (Human) 
2025-04-16 | PXD055759 | Pride
Sifi Xl-ms Mass spectrometry Ubiquitin E3 ligase Bs3 
ProteomicsDiscovery and visualization of uncharacterized drug-protein adducts using mass spectrometry
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-02-24 | PXD025019 | Pride
Magnum Raloxifene Dicloxacillin Adduct Plasma Cyp3a4 Open search Metamorpheus Comet Human serum albumin Msfragger Penicillin Moda Hsa Xenobiotic Reactive metabolite P450-reductase Flucloxacillin Open-pfind Comet-ptm Limelight 
ProteomicsAssessing protein sequence database suitability using de novo sequencing
The analysis of samples from unsequenced and/or understudied species as well as samples where the proteome is derived from multiple organisms poses two key questions. The first is whether the proteomic data obtained from an unusual sample type even contains peptide tandem mass spectra. The second ...
ORGANISM(S): glacier metagenome Hydrolagus colliei Diaphorina citri (Asian citrus psyllid) Homo sapiens (Human) marine metagenome Ursus deningeri Caenorhabditis elegans Leucoraja erinacea 
2019-11-20 | PXD015083 | Pride
Fasta Proteomics Metaproteomics 
MetabolomicsA Phosphate starvation response gene (psr1-like) is present in Micromonas pusilla and other marine algae and coordinates the metabolic response to phosphate deficiency
Both marine phytoplankton and terrestrial plants have to deal with limited bioavailability of the key life nutrient, phosphate. In freshwater algae and plants, a phosphate starvation response gene (psr1) has been characterized, which encodes for a transcription factor that regulates the metabolic re...
2016-02-01 | MTBLS295 | MetaboLights
ProteomicsAn omics-based metabolic model of methane-driven denitrification by aerobic methanotrophic bacteria
Methylomonas denitrificans is the first characterized organism that couples methane oxidation to nitrate reduction in pure culture without a partner. The aim of this study is to develop a metabolic model of methane driven nitrate respiration using a multi-level omics approach. Samples of M. denitrif...
ORGANISM(S): Methylomonas denitrificans 
2025-09-17 | PXD004041 | Pride
Methane Denitrification Omics Hypoxic Methylomonas Respiration Methanotroph Nitrous oxide Nitrate 
UnknownCarafe enables high quality in silico spectral library generation for data-independent acquisition proteomics.
Not available
S-EPMC12592563 | biostudies-literature
UnknownDe novo correction of mass measurement error in low resolution tandem MS spectra for shotgun proteomics.
Not available
S-EPMC3515694 | biostudies-literature
MetabolomicsMultiyear dynamics of recent and legacy contaminants in a German hill-slope catchment (MS2 data)

Anthropogenic activities cause the release of vast amounts of contaminants into the environment and thus also into surface- and groundwaters. Regulatory monitoring determines whether critical threshold concentrations are surpassed, by mostly occasional probing. This irregular testing, however, do...

2024-06-04 | MTBLS3533 | MetaboLights
UnknownThe Interaction Dynamics of Two Potato Leafroll Virus Movement Proteins Affects Their Localization to the Outer Membranes of Mitochondria and Plastids.
Not available
S-EPMC6265731 | biostudies-literature
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