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ProteomicsMuscle stems cell LC-MS - Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function
Abstract Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and regeneration, regulating gene expression especially via interaction with Tead transcription factors. To investigate their role in skeletal muscle stem cells, we analysed Taz in vivo and ex vivo in compar...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-13 | PXD005751 | Pride
Taz Muscle Yap 
ProteomicsAn integrated global analysis of compartmentalized HRAS signaling - Ras IP
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012505 | Pride
Hras hrasv12 hela 
ProteomicsProteomic signatures of radioresistance: Alteration of inflammation, angiogenesis and metabolism-related factors in radioresistant oesophageal adenocarcinomav
The clinical management of locally advanced oesophageal adenocarcinoma (OAC) commonly involves neoadjuvant chemoradiotherapy (CRT), but complete pathological response to CRT only occurs in 20-30% of patients, as radioresistance remains a major clinical challenge. In this study we used an established...
ORGANISM(S): Homo sapiens (Human) 
2022-08-18 | PXD020303 | Pride
Oesophageal adenocarcinoma Oac 
ProteomicsVGLL3 Skeletal Muscle - VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle
Vestigial-like (Vgll) proteins are transcriptional co-factors that have been reported to bind Tead family transcription factors to regulate various functions ranging from wing development in the fly to muscle fibre composition and immune function in mice. Here, we characterise Vgll3 in the skeletal ...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-17 | PXD012040 | Pride
Human Immunoprecipitation Ip Vgll3 
ProteomicsInhaled Multi-Walled Carbon Nanotubes modulate differently global gene and protein expression in lung rats (additipon to PXD018900)
Multi-walled carbon nanotubes (MWCNTs) are among the most promising nanomaterials because of their physical and chemical properties. However, since they are biopersistent fiber-like materials which share similarities with asbestos, concerns have arisen about their health effects. With their various ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-22 | PXD029842 | Pride
Nanotubes mwcnts rat lung 
ProteomicsInteraction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP dependent manner
Metastatic malignant melanoma is the deadliest skin cancer type, and it is characterized by its high resistance to apoptosis. The main driving mutations in melanoma cause hyperactivation of genes within the ERK pathway, with BRAF mutations being the most frequent ones, followed by NRAS, NF1 and MEK ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-18 | PXD032781 | Pride
Mst2 Apoptosis Lats1 Smac Hippo Iap Melanoma 
ProteomicsInhaled Multi-Walled Carbon Nanotubes modulate differently global gene and protein expression in lung rats
Multi-walled carbon nanotubes (MWCNTs) are among the most promising nanomaterials because of their physical and chemical properties. However, since they are biopersistent fiber-like materials which share similarities with asbestos, concerns have arisen about their health effects. With their various ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-04 | PXD018900 | Pride
Multi-walled carbon nanotubes Proteomics Rat Inhalation Transcriptomics 
ProteomicsIP C5ORF30 macrophage immunometabolism regulator gene
Expression of the macrophage immunometabolism regulator gene (MACIR) is associated with severity of autoimmune disease pathology and the regulation of macrophage biology through unknown mechanisms. The 206 amino acid protein lacks homology to any characterized protein sequence and is a disordered pr...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD016878 | Pride
Ip c5orf30 macir human rheumatoid arthritis 
ProteomicsAn integrated global analysis of compartmentalized HRAS signaling - Phosphoproteomics
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012506 | Pride
Ras phosphoproteomics minetei localisation 
Proteomicsphospho-proteomic data on the LATS1 interactome from cells treated with two proapoptotic signals: FAS and etoposide
Using this approach, we obtained phospho-proteomic data on the LATS1 interactome from cells treated with two proapoptotic signals: FAS and etoposide, which both activate LATS kinase activity [28].To identify the LATS1 interactome we transiently expressed GFP-LATS1 in HeLa cells, immunoprecipitated G...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018903 | Pride
Human Lats1 Hela 
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