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ProteomicsAncestral mechanism of Calmodulin binding to Cds1 kinase inhibits catalytic activity
SDA chemical crosslinking mass spectrometry was used to investigate the interaction between the Cds1 kinase and Ca2+-Calmodulin from Schizosaccharomyces pombe. Upon binding of Ca2+-Calmodulin, Cds1 is allosterically inhibited.
ORGANISM(S): Schizosaccharomyces pombe 
2026-09-14 | PXD070930 | Pride
Schizosaccharomyces pombe Calmodulin Calcium Cell cycle Cds1 kinase 
ProteomicsCalmodulin and CHK2 kinase crosslinking
Recombinant proteins were mixed and then crosslinked either with DMTMM or by SDA and UV exposure. Complexes were resolved by SDS-PAGE, excised and tryptic peptides identified by MS.
ORGANISM(S): Homo Sapiens (human) 
2026-03-28 | PXD062332 | JPOST Repository
ProteomicsPSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung and kidney cancers. However, little is known about PSKH1’s regulation, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spect...
ORGANISM(S): Homo sapiens (Human) 
2025-01-26 | PXD056543 | Pride
Protein kinase  allosteric regulation  calumenin  erc-55  cab-45 
ProteomicsPSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung and kidney cancers. However, little is known about PSKH1’s regulation, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spect...
ORGANISM(S): Homo sapiens (Human) 
2025-01-26 | PXD058954 | Pride
Calcium Ionomycin Pskh1 
MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
ProteomicsUbiquitylation of RIPK3 beyond-the-RHIM limits RIPK3 activity and cell death
Pathogen recognition receptors and TNF superfamily members engage Receptor Interacting Serine/threonine Kinase-3 (RIPK3) to activate programmed cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of RIPK3 signalling is not fully ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD026533 | Pride
Ripk3 Mlkl Apoptosis Caspase-8 Ubiquitin Cell death Necroptosis 
ProteomicsUbiquitin-mediated modulation of necroptotic effector MLKL
We aimed to identify lysine (K) residues that are endogenously ubiquitylated upon TNF-induced necroptosis. To this end, we used a quantitative mass spectrometry-based approach. Briefly, MDFs were treated with TSZ or left untreated and protein lysates were digested with trypsin into peptides. Ubiquit...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-13 | PXD018857 | Pride
Ubiquitin Tmt Cancer Mlkl Mouse Msms 
ProteomicsThe inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential
Interleukin-1B (IL-1B) is pathologically activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in wide-spread diseases. Therefore, IL-1B activity must be fine-tuned to enable anti-microbial responses whilst limiting collateral damage. Here we report that, relative to...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD021305 | Pride
Interleukin-1 Caspase-1 Inflammation Inflammasome Toll-like receptor Proteasome Caspase-8 Ubiquitin 
Genomicsena-DATASET-BAMS-05-01-2017-02:07:22:122-13 - samples
Whole exome sequencing data for patients with Bosma arhinia microphthalmia syndrome (BAMS). The dataset includes 21 samples from 7 families with BAMS; see Gordon et al, Nature Genetics, 2017.
EGAD00001003130 | EGA
UnknownValidation of a Crisis Standards of Care Model for Prioritization of Limited Resources During the Coronavirus Disease 2019 Crisis in an Urban, Safety-Net, Academic Medical Center.
Not available
S-EPMC8439631 | biostudies-literature
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