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ProteomicsA CRISPR/Cas9-mediated screen identifies regulators of early plasma cell differentiation
The differentiation of B cells into antibody-secreting cells depends on cell division-coupled, epigenetic and other cellular processes that are incompletely understood. We have developed a CRISPR/Cas9-based screen that models an early stage of T cell-dependent plasma cell differentiation and measure...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-22 | PXD038201 | Pride
Plasmablasts Screen Plasma cell differentiation Crispr/cas9 Regulators Gene knockout Antibody-secreting cells Plasma cells and antibody secretion 
ProteomicsProteomics of serotonergic autoregulation
Serotonin regulates its own production, degradation and release in the Raphe nuclei of the brain mainly by modifying the level and activity of autoreceptors on serotonin-producing neurons, such as 5-HT1A and 5-HT1B. This autoregulation is probably the reason for the delayed response of patients with...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055579 | Pride
Serotonin Serotonin transporter Brain Tryptophan hydroxylase Autoregulation Mouse 
ProteomicsNeurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic
We previously discovered a sex-by-genotype defect in microglia function using a germline heterozygous knockout mouse model of Neurofibromatosis type 1 (Nf1+/- mice), in which only microglia from male Nf1+/- mice exhibited defects in purinergic signaling. Herein, we leveraged an unbiased proteomic ap...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD035881 | Pride
Purinergic signaling Sex differences Neurofibromin Nf1 Cortex Microglia Genetically engineered mice 
ProteomicsSex-Specific Microglia Defects in the Neuroligin-4 Knock-Out Mouse Model of Autism Spectrum Disorder
Neuroligin-4 (NL4) loss-of-function mutations are strongly associated with monogenic heritable abnormalities linked with Autism Spectrum Disorder (ASD). NL4 mutation in mice causes ASD related alterations in both, the synaptic and behavioral phenotype. Since microglia closely regulate synaptic devel...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD024325 | Pride
Sex difference Gamma oscillation Estrogen Microglia Autism spectrum disorder 
ProteomicsProtection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-14 | PXD031972 | Pride
Sq motifs Rif1 Dsb resection inhibition Dna replication fork protection Intrinsically disordered region 
ProteomicsDistinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome
Local mRNA translation is required for adaptive changes in the synaptic proteome. The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (MNK1 and MNK2) have emerged as key regulators of neuronal translation, primarily through phosphorylation of the eukaryotic initiation fac...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD058409 | Pride
Mnk1 Tmt Synaptoneurosomes Mnk2 
ProteomicsPeritoneal metastasis of colorectal cancer (pmCRC): Identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models
14 PDX models of pmCRC were established, including 9 matched PD3D/PDX models, and treatment response to 17 SoC and targeted therapies was monitored, which resulted in drug-dependent inter- and intra-patient specific growth inhibition. Analysis of the molecular data of the models and patient tissue r...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-17 | PXD027419 | Pride
Pmcrc Proteomics Biomarkers Pdx Pd3d 
ProteomicsPeripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment
Neutrophils rapidly respond to inflammation and infection, but to which degree their functional trajectories after mobilization from the bone marrow can be shaped within the circulation remains vague. Phenotypic changes of circulating neutrophils caused by systemic inflammation are thought to result...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048335 | Pride
Neutrophils - transcriptomic plasticity - sepsis - infectious disease - multiomics 
ProteomicsProtective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remain unclear. Here, we combine a multiomics approach with lon...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD030785 | Pride
Human Plasma Sars-cov-2 Proteomics Covid-19 
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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