Sort   by:  
 Page size 
ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-28 | PXD010007 | Pride
Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1 
ProteomicsBioID of CD25 mutants in B-cell malignancies
CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing constru...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD035989 | Pride
Lc-msms B-all B-cell Cd25 Mcl Bioid Il2ra 
ProteomicsGlobal phospho-proteomics analysis of the effect of CD25 KO in precursor and mature B-cell
To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before treatment with 4-OHT to induce CD25 KO. Phosphoproteomics was performed and differential phosphosites analys...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD038996 | Pride
B-cell pre-b cd25 il2ra phospho-proteomics 
ProteomicsPhospho-Tyrosine analysis of the effect of CD25 KO in pre-B-ALL cells
To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before tratment with 4-OHT to induce CD25 KO. Phospho-Tyrosine proteomics was performed and differential phosphosit...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD036128 | Pride
Bcr-abl1 Mouse Cd25 Il2ra 
TranscriptomicsSocial Regulation of Maternal Traits in Nest-Founding Bumble Bee (Bombus terrestris) Queens
During the nest-founding phase of the bumble bee colony cycle, queens undergo striking changes in maternal care behavior. Early in the founding phase, prior to the emergence of workers in the nest, queens are reproductive and also provision and feed their offspring. However, later in the founding ph...
ORGANISM(S): Bombus terrestris 
2014-06-21 | E-MTAB-1855 | biostudies-arrayexpress
UnknownImpact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial.
Not available
S-EPMC5455690 | biostudies-literature
TranscriptomicsMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq)
FUS is a primarily nuclear RNA-binding protein with important roles in RNA processing and transport. FUS mutations disrupting its nuclear localization characterize a subset of amyotrophic lateral sclerosis (ALS-FUS) patients, through an unidentified pathological mechanism. FUS regulates nuclear RNA,...
ORGANISM(S): Mus musculus 
2021-03-05 | E-MTAB-9212 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from BCR-ABL, MYC and CD22DE12 transgenic mouse models
Leukemic splenocytes from these commercial transgenic mice that developed fatal leukemia with massive splenomegaly were isolated at the time of the necropsy and subjected to gene expression profiling and phosphoprotein profiling in side by side comparison with CD22DE12-Tg BPL or CD22DE12_BCR-ABL dou...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-58872 | biostudies-arrayexpress
GenomicsA UNIQUE ENHANCER BOUNDARY COMPLEX DEFINES THE STABLE POISED STATE OF THE MOUSE RIBOSOMAL RNA GENES IN THE ABSENCE OF RRN3, UBF AND RNA POLYMERASE I TRANSCRIPTION
Transcription of the several hundred of mouse and human Ribosomal RNA (rRNA) genes accounts for the majority of RNA synthesis in the cell nucleus and is the determinant of cytoplasmic ribosome abundance, a key factor in regulating gene expression. The rRNA genes, referred to globally as the rDNA, ar...
ORGANISM(S): Mus musculus 
2017-07-08 | E-MTAB-5839 | biostudies-arrayexpress
ProteomicsTarget engagement of Tau antibodies induces reversal of proteomic dyshomeostasis in a mouse model of tauopathy
The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localization and a vast array of post-translational modifications, including phospho...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD045799 | Pride
Mouse Alzheimer’s disease Antibody Proteomics Tau Phosphoproteomics Tauopathies 
Sort   by:  
 Page size