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ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-28 | PXD010007 | Pride
Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1 
ProteomicsBioID of CD25 mutants in B-cell malignancies
CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing constru...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD035989 | Pride
Lc-msms B-all B-cell Cd25 Mcl Bioid Il2ra 
ProteomicsGlobal phospho-proteomics analysis of the effect of CD25 KO in precursor and mature B-cell
To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before treatment with 4-OHT to induce CD25 KO. Phosphoproteomics was performed and differential phosphosites analys...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD038996 | Pride
B-cell pre-b cd25 il2ra phospho-proteomics 
ProteomicsPhospho-Tyrosine analysis of the effect of CD25 KO in pre-B-ALL cells
To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before tratment with 4-OHT to induce CD25 KO. Phospho-Tyrosine proteomics was performed and differential phosphosit...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD036128 | Pride
Bcr-abl1 Mouse Cd25 Il2ra 
ProteomicsBeta-catenin interacting proteins in BCR-ABL1+ B-ALL cells [exp1]
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in BCR-ABL1 transformed murine pre-B cells with induced beta-catenin activation via CTNNB1 exon3 fl/fl + Cre.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067271 | Pride
Pre-b B-cell 
ProteomicsIdentifying beta-catenin interacting proteins in a panel of cell lines
Affinity purification of beta-catenin interacting proteins with anti-beta-catenin antibody and IgG control in a panel of cell lines: MXP2 (B-ALL), Jeko (Mantle cell lymphoma), Molm13 (AML), Koptk (T-ALL), SW480 (Colorectal) and H446 (Lung).
ORGANISM(S): Homo sapiens (Human) 
2025-08-13 | PXD067306 | Pride
B-all B-cell lymphoma Colorectal carcinoma Lung carcinoma Aml 
ProteomicsBeta-catenin interacting proteins in WT and Ikzf1/3-KO BCR-ABL1 transformed B-ALL
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in WT (NTC control) or Ikzf1/Ikzf3-KO (dual CRISPR KO) BCR-ABL1 transformed murine pre-B cells with CTNNB1 activation via a Ctnnb1 Ex3 fl/fl + Ert2Cre model.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067318 | Pride
Pre-b B-cell 
ProteomicsBeta-catenin interacting proteins in BCR-ABL1+ B-ALL cells [exp2]
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in BCR-ABL1 transformed murine pre-B cells with induced beta-catenin activation via CTNNB1 exon3 fl/fl + Cre.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067314 | Pride
B-all 
TranscriptomicsSocial Regulation of Maternal Traits in Nest-Founding Bumble Bee (Bombus terrestris) Queens
During the nest-founding phase of the bumble bee colony cycle, queens undergo striking changes in maternal care behavior. Early in the founding phase, prior to the emergence of workers in the nest, queens are reproductive and also provision and feed their offspring. However, later in the founding ph...
ORGANISM(S): Bombus terrestris 
2014-06-21 | E-MTAB-1855 | biostudies-arrayexpress
UnknownImpact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial.
Not available
S-EPMC5455690 | biostudies-literature
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