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ProteomicsAdvancing Understanding of the Protein Composition of Human Seminal Extracellular Vesicles
Seminal extracellular vesicles (SEVs) carry a diverse array of bioactive molecules, including proteins, lipids, and nucleic acids, which influence sperm function and have potential to modulate the female reproductive tract immune response after intromission. However, the full spectrum of SEV cargo i...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-15 | PXD047212 | Pride
ProteomicsElucidation of the protein composition of mouse seminal vesicle fluid
The seminal vesicles are male accessory sex glands that contribute the bulk of the seminal plasma in which mammalian spermatozoa are bathed during ejaculation. In addition to helping convey sperm through the ejaculatory duct, seminal vesicle secretions support sperm survival after ejaculation and in...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-20 | PXD028564 | Pride
Proteomics Bioinformatics Seminal vesicle fluid 
ProteomicsImmortalized mouse caput epididymal (mECap18) cell line recapitulates in vivo environment
Between the testes and the vas deferens lies the epididymis, a highly convoluted tubule whose unique environmental characteristics are crucial for the functional maturation of spermatozoa. Within the epididymal epithelium, the secretory system releases small non-coding RNA molecules (sncRNAs) and pr...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-29 | PXD042082 | Pride
Fertility Epididymis Male reproduction Sperm maturation Proteomics. 
ProteomicsA regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool
Maintenance and self-renewal of the spermatogonial stem cell (SSC) population is the cornerstone of male fertility. In this manuscript we have identified a key role for the nucleosome remodelling protein Chromodomain Helicase DNA binding protein 4 (CHD4) in regulating SSC function. Gene expression a...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-17 | PXD022066 | Pride
Spermatogonial stem cell Chd4 Mi-2β Self-renewal 
ProteomicsIdentifying a novel hydroxysteroid dehydrogenase enzyme that is capable of testosterone biosynthesis in the mouse
Androgens, such as testosterone and dihydrotestosterone (DHT), are essential for male sexual development, masculinisation, spermatogenesis, and general lifelong health. Androgens are predominantly synthesised in the testes of mice (~95%) by highly specialised cells known as the Leydig cells. There a...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD050748 | Pride
Androgens Alternate pathway Hsd17b7 Canonical pathway Testosterone Srd5a1 Testosterone biosynthesis Hsd17b3 
ProteomicsProteomic analysis of koala (Phascolarctos cinereus) spermatozoa and prostatic bodies
The aims of this study were to investigate the proteome of koala (Phascolarctos cinereus) spermatozoa and that of the prostatic bodies with which they form intimate contact at the moment of ejaculation. For this purpose, spermatozoa and prostatic bodies were obtained from four adult male koala by el...
ORGANISM(S): Phascolarctos cinereus (Koala) 
2021-08-23 | PXD024250 | Pride
Spermatozoa Koala Prostatic bodies Proteomics 
ProteomicsPhosphoproteomic analysis of the adaption of epididymal epithelial cells to corticosterone challenge
Background: The epididymis has long been of interest owing to its role in promoting the functional maturation of the male germline. More recent evidence has also implicated the epididymis as an important sensory tissue responsible for remodeling of the sperm epigenome, both under physiological condi...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-08 | PXD028789 | Pride
Proteomics Cellular signaling Stress response Corticosterone Sperm maturation Phosphoproteomics Epididymis 
ProteomicsGlobal profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa
Spermatozoa acquire fertilization potential during passage through a highly specialized region of the extra-testicular ductal system known as the epididymis. In the absence of de novo gene transcription or protein translation, this functional transformation is extrinsically driven via the exchange o...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-21 | PXD028834 | Pride
Rhoa Proteomics Mass spectrometry Acrosome reaction Sperm maturation Epididymis Male fertility Sperm proteome Spermatozoa 
ProteomicsProteomic dissection of the impact of environmental exposures on mouse seminal vesicle function
The seminal vesicles are an integral part of the male accessory gland system, and are responsible for producing a complex array of bioactive moieties that support gamete function and promote reproductive success. However, despite their physiological significance, the biology of the seminal vesicles ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-31 | PXD021998 | Pride
Acrylamide Seminal vesicle Proteomics 
ProteomicsSystemic changes in early pregnancy in the mare: an integrated proteomic analysis of blood plasma, histotroph and yolk sac fluid at day 14 post-ovulation
Embryo-maternal signaling during the establishment of pregnancy in horses remains one of the biggest mysteries in large animal physiology. Early pregnancy loss represents a major source of economic loss to the breeding industry. This study aimed to investigate the systemic changes associated with ea...
ORGANISM(S): Equus caballus (Horse) 
2025-02-07 | PXD051312 | Pride
Transthyretin Mrp Uteroglobin Secretoglobin Early pregnancy loss Biomarker Ttr 
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