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ProteomicsN-terminomics/TAILS profiling of proteases and their substrates in ulcerative colitis
Dysregulated protease activity is often implicated in the initiation of inflammation and immune cell recruitment in gastrointestinal inflammatory diseases. Using N-terminomics/TAILS (terminal amine isotopic labeling of substrates), we compared proteases, along with their substrates and inhibitors, b...
ORGANISM(S): Homo sapiens (Human) 
2019-09-08 | PXD014479 | Pride
Protease Biopsies Ulcerative colitis Tails 
ProteomicsThe Identification of Proteolytic Substrates of Calpain-5 with N-terminomics
Calpain-5/CAPN5 is a calcium-activated, non-lysosomal cysteine (thiol) protease. The substrate spectrum repertoire of CAPN5 is not known. Calpains catalyze limited proteolysis of their substrates, generating novel neo protein N-termini that correspond to internal residues of their nascent substrate ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD064313 | Pride
Capn5 Protease Disease Tails N-terminomics Calpain-5 
ProteomicsN-terminomics/TAILS profiling of macrophages after chemical inhibition of legumain
We developed a legumain inhibitor and activtiy based probes. Murine RAW264.7 cells were subjected to N-terminomics and shotgun proteomics analysis.
ORGANISM(S): Mus musculus (Mouse) 
2019-09-05 | PXD015200 | Pride
Macrophage Protease Legumain 
ProteomicsHuman Dental Pulp TAILS N-terminomics
We report the targeted analysis of the human dental pulp proteome and N-terminome using the positional proteomics technique TAILS, which allowed us to capture both naturally blocked and unblocked protein N-termini. Furthermore, by using a proteomically barely studied human tissue in combination with...
ORGANISM(S): Homo sapiens (Human) 
2015-08-18 | PXD002264 | Pride
Human Agilent g6550a q-tof Dental pulp Tails n-terminomics Lc-ms/ms 
ProteomicsN-terminomics Analysis of Mouse cultured cortical neuron during excitotoxicity
Excitotoxicity is a primary pathological process directing neuronal cell death in both acute neurological disorders and neurodegenerative diseases such as ischemic stroke and Alzheimer’s disease. We use mouse cultured cortical neuron treated with 100uM of Glutamate for a model of excitotoxicity and ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-07 | PXD040648 | Pride
N-term Excitotoxicity 
ProteomicsHuman Dental Pulp TAILS N-terminomics
We report the targeted analysis of the human dental pulp proteome and N-terminome using the positional proteomics technique TAILS, which allowed us to capture both naturally blocked and unblocked protein N-termini. Furthermore, by using a proteomically barely studied human tissue in combination with...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-26 | MSV000082509 | MassIVE
ProteomicsN-terminomics on WT and CASP2 KO mouse hearts
To identify putative substrates processed by Caspase-2 in response to PIDDosome activation in cardiomyocytes, we performed N-terminomics by TMT10-TAILS on P7 hearts isolated from XMLC2-Casp2fl/fl and XMLC2+Casp2fl/fl mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-01-15 | PXD060421 | Pride
Tmt-tails Caspase 2 Heart developement N-terminomics 
ProteomicspNPs N-terminomics - Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets
N-terminomics (iTRAQ-TAILS) applied to the ADAMTS2, 3 and 14.
ORGANISM(S): Homo sapiens (Human) 
2016-01-12 | PXD002354 | Pride
Adamts14 Adamts2 Adamts3 
ProteomicsTAILS N-terminomics of the human dental pulp stroma and the odontoblast layer
We report the targeted analysis of the human dental pulp stroma and the odontoblast layer using the positional proteomics technique TAILS N-terminomics, which allowed us to capture both naturally blocked and unblocked protein N-termini, and to identify differences between e.g. the dental pulp proteo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083951 | MassIVE
ProteomicsIdentifying putative substrates of Calpain-15 in neurodevelopment
Calpain 15 (CAPN15) is an intracellular cysteine protease belonging to the non-classical small optic lobe (SOL) family of calpains, which has an important role in developmental processes. Loss of Capn15 in mice leads to developmental eye anomalies and volumetric changes in the brain. Human individua...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060034 | Pride
Calpain-15 Capn15 Protease Tails 
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