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TranscriptomicsEts-domain transcription factor Ets21c and nuclear receptor Ftz-F1 are novel effectors of JNK promoting tumor malignancy
Cancer represents a complex family of diseases, characterized by the uncontrolled malignant growth of a particular cell type and by metastatic dissemination of these transformed cells to secondary sites. The hallmark tumor features emerge as a result of aberrant cellular signaling and pathological g...
ORGANISM(S): Drosophila melanogaster 
2015-11-04 | E-GEOD-65261 | biostudies-arrayexpress
ProteomicsIn vivo characterization of a podocyte-expressed short podocin isoform
The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the lipid-binding protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a second shorter isoform in the human kidney in addition to the well-studied...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-20 | PXD041055 | Pride
Nephrotic syndrome Podocyte biology Focal and segmental glomerulosclerosis 
ProteomicsProteasomes of autophagy-deficient cells exhibit changes in associated regulatory proteins in conjunction with a dramatic decrease in activity
To identify possible differences in proteasome-associated proteins, we generated AX2 wild-type and ATG16¯ cells expressing the GFP-tagged 20S proteasomal subunit PSMA4 and performed co-immunoprecipitation experiments followed by mass spectrometric analysis.
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2023-07-20 | PXD039713 | Pride
Ubiquitin proteasome system (ups) Dictyostelium Autophagy Atg16 
ProteomicsCharacterization of the interactomes of YAP and TAZ in podocytes identifies a relation between YAP and TAZ and proteins of the nuclear shuttling machinery
The two effector proteins of the Hippo signaling pathway, YAP and TAZ, play a pivotal role in the cellular homeostasis of podocytes and in the pathogenesis of focal segmental glomerulosclerosis (FSGS). We aim to unravel the unique and redundant functions of YAP and TAZ in the podocyte by identifying...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD040448 | Pride
Taz Podocyte Yap Hippo signaling Fsgs Yes-associated protein 1 Wwtr1 
ProteomicsInteraction with AK2 establishes AIFM1 as organizing platform in mitochondria
Interactome of overexpressed, HA-tagged AIFM1 in HEK293T AIFM1 KO background vs control (3797, 3593), Interactome of overexpressed, HA-tagged AIFM1 variants in HEK293T AIFM1 KO background vs control (3859), Comparison of whole cell extract after gelfiltration of HEK293T AIFM1 KO cell line vs WT
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD055617 | Pride
Aifm1 Ak2 Mitochondria 
Proteomics: Remodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO
Human Umbilical Vein Endothelial Cells pooled from several donors, were purchased from Lonza and cultured in FBS reduced Endopan 3 media. HUVEC cells of passages 5-10 were used for experiments. MPO treatment was performed with protein purified from human blood (Planta) and at 1 μg/ml final concentra...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD033079 | Pride
Co-immunoprecipitation Ilf3 Endothelial cells Myeloperoxidase 
ProteomicsWhole proteome from cerebellum of 1 and 2 months old AP-2 cKO and control mice
Identification of whole proteome changes in the cerebellum of AP-2 cko and control mice at 1 and 2 months of age.
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD050031 | Pride
Cerebellum Purkinje cells Ap-2 
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