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ProteomicsProteomics of late signaling responses decipher the roles of Cbl and Cbl-b in neuroblastoma cell differentiation
We applied quantitative mass spectrometry (MS)-based proteomics to study the roles of Cbl and Cbl-b in long-term signaling responses related to neurite outgrowth and differentiation of SH-SY5Y neuroblastoma cells. Using stable isotope labeling by amino acids in cell culture (SILAC) and tandem mass t...
ORGANISM(S): Homo sapiens (Human) 
2021-03-30 | PXD020389 | Pride
Human Lc-msms Neuroblastoma Cbl Cblb 
UnknownProteomic investigation of Cbl and Cbl-b in neuroblastoma cell differentiation highlights roles for SHP-2 and CDK16.
Not available
S-EPMC8050387 | biostudies-literature
ProteomicsEGF-dependent ubiquitinome, phosphorylation and interactome analysis in control and CYLD-deficient cells
Cylindromatosis tumor suppressor protein (CYLD) is deubiquitinase, best known as an essential negative regulator of the NFkB pathway. Previous studies have suggested an involvement of CYLD in epidermal growth factor (EGF)-dependent signal transduction as well, as it was found enriched within the tyr...
ORGANISM(S): Homo sapiens (Human) 
2017-06-05 | PXD006390 | Pride
Cyld Prm Hela Phosphorylation Egfr Ubiquitin 
UnknownGABAB receptor constituents revealed by tandem affinity purification from transgenic mice.
Not available
S-EPMC2898358 | biostudies-literature
ProteomicsThe inflammation repressor TNIP1 is degraded by selective autophagy in a LIR-dependent manner upon TLR3 activation
In the project « The inflammation repressor TNIP1 is degraded by selective autophagy in a LIR-dependent manner upon TLR3 activation » Jianwen Zhou, Nikoline Lander Rasmussen, Vyacheslav Akimov, Blagoy Blagoev, Trond Lamark, Terje Johansen and Jörn Dengjel performed MS-based proteomics to study the f...
ORGANISM(S): Homo sapiens (Human) 
2022-08-07 | PXD027163 | Pride
Lc-msms Inflammation Silac Human 
ProteomicsFibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication in metabolic associated liver fibrosis
Liver fibrosis is a strong predictor of long-term mortality in patients with non-alcoholic fatty liver disease; yet the mechanisms underlying the progression from the comparatively benign fatty liver state to advanced non-alcoholic steatohepatitis (NASH) and liver fibrosis are incompletely under-sto...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-13 | PXD025691 | Pride
Prm Glis2 Liver fibrosis Elf3 Mouse Exploris 480 Nash 
UnknownCylindromatosis Tumor Suppressor Protein (CYLD) Deubiquitinase is Necessary for Proper Ubiquitination and Degradation of the Epidermal Growth Factor Receptor.
Not available
S-EPMC5546196 | biostudies-literature
ProteomicsDDI2 is a ubiquitin-directed endoprotease, responsible for cleavage of transcription factor NRF1
The Ddi1/DDI2 proteins are ubiquitin shuttling factors, implicated in a variety of cellular functions. In addition to ubiquitin-binding and ubiquitin-like domains, they contain a conserved region with similarity to retroviral proteases, but whether and how DDI2 functions as a protease has remained u...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD019152 | Pride
Ubisite Prm Ddi2 Ubiquitin Hph Lc-ms/ms 
ProteomicsPhosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow derived stromal stem cells
Bone marrow-derived mesenchymal stem cells (MSCs) differentiate into osteoblasts upon induction by signals present in their niche. As the global signaling cascades involved in the early phases of MSCs osteoblast (OB) differentiation are not well-defined, we employed quantitative mass spectrometry (S...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD011001 | Pride
Mscs Mass spectrometry Silac Differentiation Osteoblast Phosphorylation 
UnknownIdentification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12.
Not available
S-EPMC9788571 | biostudies-literature
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