Sort   by:  
 Page size 
ProteomicsNur77 resolves the inflammatory response of macrophages primarily by cis- and trans-regulation of AP-1 target genes
Nuclear receptor Nur77 plays a crucial, protective role in chronic inflammation. In activated macrophages, deficiency of Nur77 has been shown to result in excessive pro-inflammatory cytokine secretion. Previous research suggested that Nur77's regulatory function in inflammation is due to repression ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD054271 | Pride
Lc-ms/ms Nr4a1 Ap-1 Macrophage Inflammation 
ProteomicsHistidine to glutamine substitutants, a regulated process that impacts cell survival and pinpoints histidine shortage in cancer
Cancer-associated genetic, epigenetic, and microenvironmental factors enforce tryptophan and arginine shortages that induce specific codon reassignments (substitutants) in their proteomes. Evidence for the impact of shortages of other amino acids on cancer translation is lacking. Here, we investigat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD060514 | Pride
Substituants Histidine shortage Glutamine Proteome Cancer 
ProteomicsArginine to Cysteine substitutants in lung cancer enhance survival to chemotherapy
Tryptophan and arginine are the two most prominent restrictive amino acids linked to anti-tumor activity. For tryptophan, the induction of indoleamine 2,3-dioxygenase 1 (IDO1) by interferon-gamma (IFNg) secreted by T cells, catabolizes tryptophan to kynurenine to suppress T cell activity. For argini...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043612 | Pride
Arginine Substituants Keap1 Lung cancer Tryptophan 
ProteomicsMULTIMODAL STIMULATION SCREENS REVEAL UNIQUE AND SHARED GENES LIMITING T-CELL FITNESS
T-cell dysfunction genes limit antitumor activity and may serve as therapeutic targets. It has not been systematically studied whether there are regulators that either uniquely or broadly contribute to T-cell fitness. We performed genome-scale CRISPR/Cas9 knockout screens in primary CD8 T-cells to u...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-16 | PXD043545 | Pride
T-cells Dap5 Exhaustion Ctbp1 Activation-induced cell death Crispr/cas9 screen Icam1 Effector function Cancer immunotherapy Dysfunction 
ProteomicsArginine deprivation of ASS1-deficient cancers drives mistranslation and shared neoepitope production
Arginine biosynthesis is frequently suppressed in human cancer due to loss of argininosuccinate synthetase 1 (ASS1) expression, rendering cancer cells reliant on extracellular arginine. This observation propelled the development of systemic arginine depletion strategies, which are clinically safe bu...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD068912 | Pride
ProteomicsChemotherapy-induced codon-specific immunopeptidome diversification
Deregulated mRNA translation in cancer is a source of aberrant protein production when tryptophan shortage is induced by anti-tumor immunity (refs). Tryptophan is decoded by only one codon, and currently the consequences of aberrant protein production in conditions of a shortage of amino acids decod...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044085 | Pride
Aberrant protein Mrna translation Tryptophan Leucine Ribosomal stalling Immunopeptidomics Neoepitopes 
ProteomicsGlobal and specific mechanisms stimulate mistranslation in cancer
In the context of anti-tumor immunity, activated T cells secrete interferon-gamma (IFNγ) to induce indoleamine 2,3-dioxygenase (IDO1) in the target cancer cells. High IDO1 levels deplete tryptophan, leading to aberrant protein production due to tryptophan to phenylalanine codon reassignments (W>F su...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD060710 | Pride
Lc-msms Anti-tumor immunity W>f substitutants Ftsj1 Neo-epitopes 
ProteomicsTriple-Triple-Negative Breast Cancer Shapes the Systemic Immune Landscape and Alters Neutrophil Functionality
Cancer dysregulates intratumoral adaptive-innate immune cell crosstalk, however, it remains largely unknown how the systemic immune landscape is modified during breast cancer progression and whether prior chemotherapy treatment exerts persistent changes on circulating immune cells. Here, we comprehe...
ORGANISM(S): Homo sapiens (Human) 
2025-04-09 | PXD051334 | Pride
Triple-negative breast cancer Neutrophil Proteome Immune system 
ProteomicsQuantitative Proteomics Illuminates A Functional Interaction Between Mouse Homolog Of Diaphanous 2 (mDia2) And The Proteasome
Formin mDia2 is a cytoskeleton-regulatory protein that switches reversibly between a closed, auto-inhibited and an open, active conformation. Although the open conformation of mDia2 induces actin assembly thereby controlling many cellular processes, mDia2 possesses also actin-independent and conform...
ORGANISM(S): Homo sapiens (Human) 
2016-12-14 | PXD002066 | Pride
Human Hela Mdia2 Proteasome Ubiquitin 
ProteomicsTRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination
The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number of interacting proteins, many AR coregulators remain to be characterized in relation to their disti...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD058914 | Pride
Ar Trim33 Rime Lc-msms 
Sort   by:  
 Page size