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ProteomicsAnalysis of mini-SHIP1 with pY Peptide by HDX-MS
Hydrogen deuterium exchange mass spectrometry (HDX-MS) was used to analyze how the mini-SHIP1 construct interacts with receptor-derived phosphotryrosine peptides (pY) to probe how these peptides regulate SHIP1 autoinhibition. This HDX-MS helped to identify intramolecular contacts involved in the reg...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD061719 | Pride
Ship1 Hdx-ms 
ProteomicsHydrogen Deuterium Exchange of MAF1 and RalGAP
A Toxoplasma gondii MAF1b - human RalGAPα1 complex highlights a potentially previously uncharacterized immunomodulatory role for MAF1b
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD034607 | Pride
Hdx Hdx-ms Ralgap Maf1 
ProteomicsHDXMS of PI4KIIIa and Calcineurin
Using HDX-MS to reveal the binding sites of Calcineurin and PI4KIIIa
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025900 | Pride
Hdx-ms Pi4kiiia Calcineurin 
ProteomicsUsing HDX-MS to study Rab and Ral covalently bound to MRTX1257
Here we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD041440 | Pride
Rab Hdx-ms Ral Hdx Gtpase 
ProteomicsHDX-MS analysis of NKp46 with next gen antibodies
Eptiopes of 7 unique antibodies produced by two complementary in vivo platforms utilizing a common light chain, in a chicken (OmniClic) or rat (OmniFlic) host species on NKp46 were analysed using HDX-MS. NKp46 was used as a model target antigen due to its use in emerging Natural Killer (NK) immune e...
ORGANISM(S): Homo sapiens (Human) 
2025-11-27 | PXD069455 | Pride
Epitope Antibody Nkp46 Hdx 
ProteomicsStudy of the TRAPP complexes by HDX-MS
Use of HDX-MS to study the allosteric and structural differences between the TRAPPII and TRAPPIII complex in the presence and absence of membrane and rab GTPases
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025928 | Pride
Trappii trappiii rab hdx-ms 
ProteomicsHDX-MS analysis of binding interfaces on ARMH3 in the presence of Arl5b(GTPyS) and GBF1
We carried out 4 HDX-MS experiments to investigate the ARMH3 interactions with PI4Kb, Arl5b(GTPyS) and GBF1 (ARMH3+Arl5b, ARMH3+GBF1(1-709)) and ARMH3+GBF1(364-395)). Analysis of these four experiments defined the Arl5b intereface on ARMH3 and defined the disordered linker region located in the DCB-...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD080671 | Pride
Armh3 Gbf1 Hdx-ms. pi4kb 
ProteomicsHDX-MS analysis of a TTC7B specific nanobody to inhibit EFR3 mediated PI4KA recruitment
Phosphatidylinositol 4 kinase III (PI4KIII/PI4KA) is an essential lipid kinase that is critical for regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane through targeted recruitment by the proteins EFR3A and EFR3B, with these binding to the PI4KA accessory protein...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD066213 | Pride
Pi4ka Hdx-ms Nanaobody Ttc7b 
ProteomicsIn vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid 19 phosphatidylinositol-3-phosphate (PI3P) downstream of growth factor signaling and 20 by Vps34-mediated PI3P production during autophagy. Upregulation of Sgk3 activity 21 has been linked to a number of human cance...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025327 | Pride
Kinase Sgk3 Hdx-ms Pi3p 
ProteomicsAnalysis of mng-SHIP1-dCT with pY Peptide by HDX-MS
Hydrogen deuterium exchange mass spectrometry (HDX-MS) was used to analyze how the mng-SHIP1-dCT construct interacts receptor-derived phosphotryrosine peptides (pY) to probe how these peptides regulate SHIP1 autoinhibition. This HDX-MS helped to identify intramolecular contacts involved in the regul...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD058704 | Pride
Ship1 Hdx-ms 
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