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UnknownPrognostic value of whole lymph node molecular analysis in colorectal cancer: a prospective multicenter study.
Not available
S-EPMC12644202 | biostudies-literature
UnknownPrognostic Expression Signature of <i>RB1</i>, <i>PTEN</i>, and <i>TP53</i> Genes in Patients with Metastatic Hormone-sensitive Prostate Cancer Treated with Androgen Receptor Pathway Inhibitors.
Not available
S-EPMC11536031 | biostudies-literature
ProteomicsSUMO operates from a unique long tandem repeat to keep innate immunity in check
The SUMO pathway mainly functions to repress innate immunity in myeloid cells. Inactivating sumoylation triggers a strong, noncanonical, type I interferon (IFN1) response, amplified and coupled with inflammation upon stimulation. These findings transposed to pre-clinical models with the demonstratio...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-16 | PXD061276 | Pride
Sumo Sumoylation H3.3 Ifn1 H3k9me3 Morc3 
UnknownAtrial appendages' mechanics assessed by 3D transoesophageal echocardiography as predictors of atrial fibrillation recurrence after pulmonary vein isolation.
Not available
S-EPMC7522341 | biostudies-literature
ProteomicsRNF212B E3 ligase is essential for crossing over maturation and mouse fertility
Meiosis, a reductional cell division, relies on precise initiation, maturation and resolution of crossovers (COs)-connections between homologs chromosomes-to ensure their accurate segregation during metaphase I. This process is finely regulated in eukaryotes by the interplay of RING-E3 ligases such ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-31 | PXD047019 | Pride
Crossing-over Ubiquitylation Meiotic recombination Chiasma Fertility Sumoylation Rnf212b Ring e3 ligases Spermatogenesis 
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation (total proteome)
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD029409 | Pride
Scai Xenopus Total proteome Interstrand crosslink repair Npe Dna damage Icl Fanci Fancd2 
UnknownReal-world evidence of nivolumab monotherapy in advanced renal cell carcinoma from a multicenter retrospective cohort study by the Spanish Genitourinary Oncology Group.
Not available
S-EPMC12664163 | biostudies-literature
ProteomicsMechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO pathway
DNA-protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin- and DNA replication-dependent manner by SPRTN or the proteasome but can also be resolved via targeted SUMOylation. Howe...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2021-08-06 | PXD021947 | Pride
Rnf4 Xenopus Dpc Chromass Dna damage Replication Sumo Pias4 
ProteomicsThe E3 ubiquitin ligase RFWD3 is required for translesion DNA synthesis
Lesions on DNA can uncouple DNA synthesis from helicase unwinding, generating stretches of unreplicated single stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication and thereby avoid the generation of DNA double-stranded breaks (DSBs), a ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-12-15 | PXD018217 | Pride
Chromass Tls Xenopus Rfwd3 Dna Damage Ubiquitin Pcna Ts 
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD024280 | Pride
Scai Xenopus Interstrand crosslink repair Chromass Dna damage Icl Fanci Fancd2 
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