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ProteomicsPancreatic ductal adenocarcinoma (PDAC) ubiquitination profiling reveals specific prognostic and theranostic markers.
The project was aimed at identifying diGlycine (diGly) conjugated peptides obtained from sixty PDACs' patients' derived xenografs (PDXs) then to identify potential diGLy profiles that could be used as prognosis markers of the aggressiveness of the tumour and overall survival of patients as well as t...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD030011 | Pride
Theranostic markers. Ubiquitinome Digly peptide profiling Prognostic markers Lc-msms Pdac 
ProteomicsdiGly ubiquitin remnant profiling upon TFEB overexpression
We performed proteomic analysis of di-Gly peptides to identify which proteins are ubiquitinated in cells overexpressing TFEB compared to non-expressing cells.
ORGANISM(S): Homo sapiens (Human) 
2025-11-18 | PXD065497 | Pride
Ubiquitin Digly Tfeb Hela 
ProteomicsRole of ITCH in the endolysosomal damage response
Ubiquitin remnant (diGly) profiling of parental and ITCH knockout (KO) cells under endolysosomal damage conditions (LLOMe).
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD039088 | Pride
Digly Itch Lysosome Llome Ubiquitin 
ProteomicsUbiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis
The GID/CTLH E3 ligase complex is implicated in several biological processes, yet its full substrate repertoire remains poorly defined. We recently identified the complex as a broad modulator of macrophage responses to Mycobacterium tuberculosis (Mtb) infection. Here, we use label-free proteomics a...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-24 | PXD075792 | Pride
Metabolism Innate immunity Ubiquitylation Tuberculosis Gid/ctlh complex Macrophages 
ProteomicsUbiquitinome Profiling: Optimizing the enrichment and Data-Independent Analysis for Deeper Insights into Targeted Protein Degradation
Targeted protein degradation has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein degradation, plays a critical role in this process. Gaining comprehens...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD057960 | Pride
Digly Protac Dia 
ProteomicsUbiquitinome Profiling: Optimizing the enrichment and Data-Independent Analysis for Deeper Insights into Targeted Protein Degradation
Targeted protein degradation has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein degradation, plays a critical role in this process. Gaining comprehens...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD059978 | Pride
Ubiquitination Digly Adprom Mapt 
ProteomicsUbiquitinome profiling reveals in vivo UBE2D3 targets and implicates UBE2D3 in protein quality control.
Ubiquitination has crucial roles in many cellular processes and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2) enzymes to support the ubiquitination of many cellular targets. As individual E2 enzym...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-13 | PXD035045 | Pride
Ubiquitinome Silac Ube2d3 
ProteomicsUbiquitin profiling of drug-like small molecule-treated cells
The ubiquitin system regulates eukaryotic physiology by modifying specific substrate proteins. Substrate recognition and the assembly of ubiquitin signals are determined by ubiquitin ligases, some of which also modify non-protein biomolecules. Here we expand this substrate realm, revealing that the ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD067088 | Pride
Drug-like small molecules Digly Ubiquitin Huwe1 
ProteomicsData-independent acquisition approach for comprehensive ubiquitinome profiling in targeted protein degradation
Targeted protein degradation (TPD) has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein degradation, plays a critical role in this process. Gaining comp...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD060403 | Pride
Ubiquitinome Pp2ca Dtag 
ProteomicsData-independent acquisition approach for comprehensive ubiquitinome profiling in targeted protein degradation
Targeted protein degradation (TPD) has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein degradation, plays a critical role in this process. Gaining comp...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD061232 | Pride
Ubiquitinome Dtag Tpd 
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