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ProteomicsDynamics of AMPAR proteome across brain regions and in postnatal development
Native AMPA receptors (AMPAR) in the mammalian brain are macromolecular complexes whose functional characteristics vary across brain regions and postnatal development and change in response to neuronal activity. Both, structural and functional properties of the AMPARs are determined by their proteom...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-06 | PXD001195 | Pride
Lc-msms Ap-ms Rat Development Ampa receptor Brain regions Proteome 
ProteomicsA ternary Neurexin-T178-PTPR complex represents a core-module of neuronal synapse organization
Complexes of synaptic adhesion molecules instruct the formation, functional specification and plasticity of neuronal synapses. Proteomic and candidate gene studies have identified an array of synaptic adhesion molecules that may cooperate or provide independent columns connecting synaptic compartmen...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2026-07-24 | PXD054017 | Pride
Mouse Synapse Neuron Brain Ap-ms. ms 
ProteomicsIntegral membrane proteome of adult mouse brain and other organs
LC-MS/MS analysis with label-free quantification was used to determine the expression levels of ion transporters, particularly those involved in Ca2+ homeostasis
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD060109 | Pride
Protein expression levels Tissue specificity Integral membrane proteome Ca2+ homeostasis Mouse brain 
ProteomicsThe molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
The transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a ubiquitously expressed membrane protein consisting of an ion channel domain and an intracellularly located protein kinase domain. TRPM7 plays a fundamental role in the cellular uptake of divalent cations such as Zn2+...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Rattus norvegicus (Rat) 
2021-11-29 | PXD025279 | Pride
Ap-ms Lc-ms Csbn-ms Magnesium Cnnm Calcium Trpm7 Arl15 Zinc 
ProteomicsA slit-diaphragm-associated protein network for dynamic control of renal filtration
The filtration of blood in the kidney which is crucial for mammalian life is determined by the slit-diaphragm (SD), a proteinaceous junction between the foot processes of renal podocytes. Based on studies of structure and function the SD has been hypothesized to operate as a final barrier or as a ‘m...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-09-20 | PXD034356 | Pride
Ap-ms Kidney Podocytes Rat Neph1 Nephrin Podocin Mouse Slit-diaphragm Orbitrap Renal filtration Lc-ms/ms 
ProteomicsComplex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GB...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-13 | PXD012487 | Pride
Gabab receptors Cellular neuroscience Lc-ms/ms 
ProteomicsCryo-slicing BN-MS of rat brain mitochondrial proteins
Blue-native gel electrophoresis (BN) is a powerful method for protein separation. Combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) it enables large-scale identification of protein complexes and their subunits. Current BN-MS approaches, however, are limited in size resolution, ...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-12-01 | PXD002681 | Pride
Cryo-slicing bn-ms lc-ms/ms complexome proteine profiles 
ProteomicsAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neuro-transmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the en...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-17 | PXD006413 | Pride
Excitatory synaptic transmission Proteomic analysis Intellectual disability Ampa-receptor biogenesis complexes 
ProteomicsGSG1L-containing AMPA receptors are complexes with unique spatiotemporal expression, subunit composition and gating properties
Transmembrane AMPA receptor regulatory proteins (TARPs) and germ cell-specific gene 1-like protein (GSG1L) are claudin-type AMPA receptor (AMPAR) auxiliary subunits that profoundly regulate glutamatergic synapse strength and plasticity. While AMPAR-TARP complexes have been extensively studied, less ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-26 | PXD044621 | Pride
Lc-ms/ms Interactomics 
ProteomicsSynaptotagmin-11 facilitates transport and stabilization of pre-assembled presynaptic GABAB receptor/Cav2.2 signaling complexes
GABAB receptors (GBRs), the G protein-coupled receptors for GABA, regulate synaptic transmission throughout the brain. A main synaptic GBR function is the gating of ion channels. However, where stable GBR-effector channel signaling units are formed in the biosynthetic pathway has remained unclear. ...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-10 | PXD044764 | Pride
Lc-ms/ms Interactomics 
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