Graham Mark S MS

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Unknown (18)
Proteomics (16)
Genomics (15)
Transcriptomics (2)
Metabolomics (2)

Organisms

Homo sapiens (23)
Mus musculus (9)
Rattus norvegicus (1)

Repository

pride (16)
EGA (15)
biostudies-arrayexpress (2)
MetaboLights (2)

Tissue

Brain (9)
Cell culture (4)
Hippocampus (4)
Blood (3)
Blood cell (2)
Primary neuron (2)
Cerebral cortex neuron (1)
Embryonic stem cell (1)
Hippocampal neuron (1)
Monocyte (1)
Neural progenitor cell (1)
Neural retina (1)
Neuron (1)
Neuron of cerebral cortex (1)
Permanent cell line cell (1)
Pluripotent stem cell (1)

Disease

Alzheimer's disease (2)
Disease free (1)
Epilepsy (1)
Kabuki syndrome (1)
Neurological dysfunction (1)
Obsessive-compulsive disorder (1)
Status epilepticus (1)

Technology Type

Mass Spectrometry (16)
Shotgun proteomics (9)
Illumina 15K (8)
Data-dependent acquisition (6)
Mass spectrometry (2)
SRM/MRM (2)
Affinity purification coupled with mass spectrometry proteomics (1)
Bottom-up proteomics (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

Liquid Chromatography MS - - - LTQ Orbitrap Velos (Thermo Scientific) (1)
Thermo LTQ XL linear ion trap (1)

Publication Date

2026 (4)
2024 (4)
2025 (3)
2022 (3)
2011 (1)
2007 (1)
2017 (1)
2014 (1)
2023 (1)
2019 (1)

CHEBI ID

CHEBI:1113 (1)
CHEBI:15676 (1)
CHEBI:15741 (1)
CHEBI:16016 (1)
CHEBI:16108 (1)
CHEBI:16112 (1)
CHEBI:16217 (1)
CHEBI:16292 (1)
CHEBI:16308 (1)
CHEBI:16335 (1)
CHEBI:16426 (1)
CHEBI:16443 (1)
CHEBI:16551 (1)
CHEBI:16680 (1)
CHEBI:16704 (1)
CHEBI:16750 (1)
CHEBI:16885 (1)
CHEBI:16934 (1)
CHEBI:16941 (1)
CHEBI:16977 (1)
CHEBI:17053 (1)
CHEBI:17081 (1)
CHEBI:17108 (1)
CHEBI:17191 (1)
CHEBI:17196 (1)
CHEBI:17215 (1)
CHEBI:17270 (1)
CHEBI:17335 (1)
CHEBI:17368 (1)
CHEBI:17369 (1)

Metabolite Name

(+)-Aspidospermidine (1)
(3-hydroxy-2-octadeca-9,12-dienoyloxypropyl) octadeca-9,12-dienoate (1)
(Z)-5-Hexadecenoic acid (1)
1,2,3,6-Tetragalloylglucose (1)
1,2,4,5-Tetrathiane (1)
1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine (1)
1,3-Diarachidin (1)
1,6-DINITROPYRENE (1)
1,7-di-O-phosphonohept-2-ulose (1)
1-Hydroxy-3-methoxy-7-primeverosyloxyxanthone (1)
2,3-Dimercaptosuccinic acid (1)
2-(4-Chloro-3,5-dimethylphenoxy)-N-(2-phenyl-2H-benzotriazol-5-yl)-acetamide (1)
2-(Methylthio)benzothiazole (1)
2-Amino-5-chloromuconate 6-semialdehyde (1)
2-Hydroxy-2-methylbutyric acid (1)
2-amino-4-oxo-4-phosphonooxybutanoic acid (1)
2-ureidoglycine (1)
3,5,3'-triiodothyropyruvic acid (1)
3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (1)
3-(4-hydroxy-3,5-diiodophenyl)-2-oxopropanoic acid (1)
3-(Methylthio)acryloyl-CoA; Methylthioacryloyl-CoA; 3-(Methylsulfanyl)acryloyl-CoA (1)
3-Bromo-5-chloro-2,6-dihydroxybenzoic acid (1)
3-Deazauridine (1)
3-Hydroxypyridine sulfate (1)
3-O-Methylquercetin (1)
4'-Chloroacetanilide (1)
4-Hydroxyquinoline (1)
4-Keto-anhydrotetracycline; 4-Ketoanhydrotetracycline; 4-Keto-ATC; 4-Dedimethylamino-4-oxo-anhydrotetracycline; 4-De(dimethylamino)-4-oxoanhydrotetracycline; (4aR,12aS)-3,10,11,12a-Tetrahydroxy-6-methyl-1,4,12-trioxo-4a,5-dihydrotetracene-2-carboxamide (1)
5-Amino-4-chloro-2-(5-hydroxymuconoyl)-3(2H)-pyridazinone; 5-Amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone (1)
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid (1)

Study type

Comparative genomic hybridization by array (1)
Transcription profiling by array (1)

Release Date

2020 (5)
2022 (3)
2021 (3)
2025 (2)
2024 (2)
2011 (1)
2007 (1)
2023 (1)
2019 (1)
2014 (1)

Lab affiliation

Queensland Brain Institute, The University of Queensland, St Lucia Campus (Brisbane), QLD 4072, Australia (2)
Synapse Proteomics, Children's Medical Research Institute, Australia (2)
Cell Biology of Infection Laboratory, The Francis Crick Institute, London, UK Division of Medicine, University College London, London, UK (1)
Children's Medical Research Insitute, The University of Sydney (1)
Children's Medical Research Institute (1)
Institute of Cellular Neurosciences II, University of Bonn (1)
Kids Neuroscience Centre (1)
Kids Neuroscience Centre, Kids Research, Sydney Children Hospital Network (1)
Kids Neuroscience Centre, The Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney (1)
School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia (1)
Synapse Proteomics Group, Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia (1)
Synapse Proteomics, Children's Medical Research Insitute (1)
Synapse Proteomics, Children's Medical Research Insitute, The University of Sydney, Australia (1)
Synapse Proteomics, Children’s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road Westmead NSW 2145 Australia. (1)

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WTCCC1 project Multiple Sclerosis (MS) samples

EGAD00000000012 | EGA

Phosphoproteome of five-minute KCl-depolarised mouse cultured hippocampal neurons

Cultured hippocampal neurons from mice were treated with high concentration KCl for five minutes to depolarise the plasma membrane and model sustained brain activity. A high KCl condition was compared to low KCl using phosphoproteomics. Phosphopeptides were enriched from trypsin digested bio-replica...

ORGANISM(S): Mus musculus (Mouse)

2023-10-15 | PXD020232 | Pride

Phosphoproteomic and proteomic analysis of early epileptogenesis in mice at 4 and 24 h post-status epilepticus

The phosphorylation-based signalling and protein changes occurring in the early phases after a pathophysiological insult, like status epilepticus, have not been detailed. To this end, the hippocampi of mice treated with pilocarpine and diazepam were examined by mass spectrometry at 4 and 24 h post-s...

ORGANISM(S): Mus musculus (Mouse)

2024-02-22 | PXD038241 | Pride

Epileptogenesis Phosphoproteome Epilepsy Hippocampus Phosphorylation Mouse Proteome Tandem mass tag Phospho-signalling

Phosphoproteomic analysis of mouse neurons with SRPK2 overexpression or knockdown

SRPK2 was identified as a presynaptic protein kinase involved in the regulation of neurotransmitter release. The phosphoproteome of mouse primary neurons was screened, under the conditions of SRPK2 overexpression and SRPK2 knockdown, to identify candidate substrates of SRPK2.

ORGANISM(S): Mus musculus (Mouse)

2022-02-14 | PXD016636 | Pride

Brain Mouse Phosphorylation Srpk2

Metabolic differences in ripening of Solanum lycopersicum 'Ailsa Craig' and three monogenic mutants (alternative assay to MTBLS36)

The purpose of this study was to highlight metabolic differences between different cultivars of tomato through development and ripening. Application of mass spectrometry enables the detection of metabolic differences between groups of related organisms. Differences in the metabolic fingerprints of w...

2017-10-18 | MTBLS73 | MetaboLights

Proteomics characterisation of induced pluripotent stem cells and cortical brain organoids.

A method was developed to reproducibly produce neural retina and cortical brain regions from confluent cultures of stem cells. The spontaneously generated cortical organoids were isolated and cultured in suspension conditions for maturation. Proteomic analysis of both the original induced pluripoten...

ORGANISM(S): Homo sapiens (Human)

2022-05-06 | PXD025933 | Pride

Cortical Stem cell Proteomics Brain Neural retina Organoid Pluripotent

The temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation

Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...

ORGANISM(S): Rattus norvegicus (Rat)

2019-01-28 | PXD010007 | Pride

Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1

Mass spectrometry analysis of ABC transporter proteins in pilocarpine mouse model of epilepsy

Hippocampal tissue from pilocarpine treated mice was examined by mass spectrometry to determine the change in levels of ABC transporter proteins.

ORGANISM(S): Mus musculus (Mouse)

2022-12-03 | PXD037454 | Pride

Tmt Pilocarpine Mouse Abc transporter

PRM validation of phosphoproteomic and proteomic analysis of early epileptogenesis in mice at 4 and 24 h post-status epilepticus

The phosphorylation-based signalling and protein changes occurring in the early phases after a pathophysiological insult, like status epilepticus (SE), have not been detailed. In a companion project, the hippocampi of mice treated with pilocarpine and diazepam were examined by tandem mass tag (TMT11...

ORGANISM(S): Mus musculus (Mouse)

2024-02-22 | PXD047870 | Pride

Epileptogenesis Phospho-signalling Proteomics Epilepsy Hippocampus Synaptic weakening Signalling Phosphorylation Mouse Parallel reaction monitoring Synapse growth

Metabolic differences in ripening of Solanum lycopersicum 'Ailsa Craig' and three monogenic mutants

Application of mass spectrometry enables the detection of metabolic differences between groups of related organisms. Differences in the metabolic fingerprints of wild-type Solanum lycopersicum and three monogenic mutants, ripening inhibitor (rin), non-ripening (nor) and Colourless non-ripening (Cnr)...

2014-02-07 | MTBLS36 | MetaboLights

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53 Results

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