Sort   by:  
 Page size 
ProteomicsSUMO operates from a unique long tandem repeat to keep innate immunity in check
The SUMO pathway mainly functions to repress innate immunity in myeloid cells. Inactivating sumoylation triggers a strong, noncanonical, type I interferon (IFN1) response, amplified and coupled with inflammation upon stimulation. These findings transposed to pre-clinical models with the demonstratio...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-16 | PXD061276 | Pride
Sumo Sumoylation H3.3 Ifn1 H3k9me3 Morc3 
ProteomicsStructure of a contractile injection system in Salmonella enterica subsp. salamae
Extracellular contractile injection systems (eCISs) are phage-derived nanomachines used by bacteria to deliver effectors into target cells. Well-studied examples include the Photorhabdus asymbiotica virulence cassettes and the antifeeding prophage from Serratia entomophila, which have been engineere...
ORGANISM(S): Salmonella enterica subsp. salamae 
2026-03-06 | PXD063506 | Pride
ProteomicsQuantitative chromatin protein dynamics during replication origin firing in human cells (part 2)
Accurate genome duplication requires a tightly regulated DNA replication program, which relies on the fine regulation of origin firing. While the molecular steps involved in origin firing have been determined predominantly in budding yeast, the complexity of this process in human cells has yet to be...
ORGANISM(S): Homo sapiens (Human) 
2025-01-24 | PXD058340 | Pride
Dna replication Origin firing Chk1 Kinase Dna damage Chromatin 
ProteomicsQuantitative chromatin protein dynamics during replication origin firing in human cells (part 1)
Accurate genome duplication requires a tightly regulated DNA replication program, which relies on the fine regulation of origin firing. While the molecular steps involved in origin firing have been determined predominantly in budding yeast, the complexity of this process in human cells has yet to be...
ORGANISM(S): Homo sapiens (Human) 
2025-01-24 | PXD047108 | Pride
Dna replication Origin firing Chk1 Kinase Dna damage Chromatin 
ProteomicsInterferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System
Biomolecular condensates are cellular compartments without enveloping membranes, enabling them to dynamically adjust their composition in response to environmental changes through post-translational modifications. A recent study has revealed that interferon-induced ADP-ribosylation (ADPr), which can...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD057944 | Pride
Dtx3l Adpr Parp P62 Biomolecular condensates 
ProteomicsCatalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis
Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate DNA polymerases, polymerase kappa (PolK) has the distinctive ability to bypass minor groove DNA adduct...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-08-27 | PXD044258 | Pride
Xenopus Tls Polz Polk Rev1 Polymerase kappa Ubiquitin Translesion dna synthesis Pcna Dna replication 
ProteomicsExtensive protein group SUMO modification of repressive chromatin factors distinguishes pluripotent from somatic cells
Post-translational modification by SUMO is a key regulator of cell identity. In mouse embryonic fibroblasts (MEFs), SUMO impedes reprogramming to pluripotency, while in embryonic stem cells (ESCs), it represses the emergence of totipotent-like cells, suggesting that SUMO targets distinct substrates ...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-16 | PXD017697 | Pride
Mef Sumo Somatic Endogenous Stem cells Esc Pluripotent Chromatin 
ProteomicsRNF212B E3 ligase is essential for crossing over maturation and mouse fertility
Meiosis, a reductional cell division, relies on precise initiation, maturation and resolution of crossovers (COs)-connections between homologs chromosomes-to ensure their accurate segregation during metaphase I. This process is finely regulated in eukaryotes by the interplay of RING-E3 ligases such ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-31 | PXD047019 | Pride
Crossing-over Ubiquitylation Meiotic recombination Chiasma Fertility Sumoylation Rnf212b Ring e3 ligases Spermatogenesis 
ProteomicsBrief suppression of SUMOylation in embryonic stem cells generates embryo-like structures
Recent advances in synthetic mammalian embryo models have opened new avenues to understand the complex events controlling lineage specification and morphogenetic processes occurring during peri-implantation and early organogenesis. Two main strategies have been developed to build embryo-like structu...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-13 | PXD031548 | Pride
Embryo-like structures Repression Sumo Endogenous Stem cells Spheroids Chromatin 
ProteomicsWaves of sumoylation support transcription dynamics during adipocyte differentiation
Tight control of gene expression networks involved in adipose tissue formation and plasticity is required to adapt to energy needs and environmental cues. However, little is known about the mechanisms that orchestrate the dramatic transcriptional changes leading to adipocyte differentiation. We inve...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-18 | PXD024144 | Pride
Transcription Sumo Adipocyte Endogenous Differentiation Adipose tissue Native Chromatin 
Sort   by:  
 Page size