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ProteomicsHuman brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia
Understanding the pathophysiological substrates of schizophrenia is a major challenge for current neuropsychiatric research. As part of a set of multi-omics experiments, we performed an extensive case-control proteomics study on 192 post-mortem tissue sections from prefrontal cortex from 96 individu...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD058441 | Pride
ProteomicsMultimodal Proteomics reveals dysregulated secretion and ECM remodeling in schizophrenia patient iPSC-derived astrocytes
Astrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear. Here, we use mass spectrometry–based proteomics to profile lysates (proteome) and secreted (secretome) proteins...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD075039 | Pride
Astrocytes Proteomics Ipsc Schizophrenia Protein secretion 
ProteomicsThe proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
By combining immunohistochemistry (IHC) and laser microdissection (LMD) we isolated neurons with GVD and those bearing tangles separately from human post-mortem AD hippocampus (n=12) using their typical markers casein kinase (CK)1δ and phosphorylated tau (AT8). Control neurons were isolated from cog...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023199 | Pride
Alzheimer´s disease Neurofibrillary tangles Granulovacuolar degeneration Tau Neuropathology Proteomics 
ProteomicsMultifactorial neuroprotective effects of BNN27, a Nerve Growth Factor mimetic, in the 5xFAD mouse model of Alzheimer’s Disease
Neurotrophic factors consist major regulatory molecules and their decline in Alzheimer's disease is considered as an important cause of disease progression. Novel pharmacological approaches are targeting the downstream pathways controlled by neurotrophins, such as nerve growth factor (NGF) receptors...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-25 | PXD044699 | Pride
Mouse Proteomics Brain Hippocampus Lc-ms Bnn27 5xfad Directdia 
ProteomicsComparative analyses of data independent acquisition mass spectrometric approaches: DIA, WiSIM-DIA and directDIA
With a multitude of DIA approaches developed recently, many of their features are not yet well explored. In this study we make use of a biologically relevant sample, the synaptosome, as a model to compare the spectral libraries generated by (1) DDA solely on Orbitrap (OT), (2) Orbitrap for MS1 scan...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-20 | PXD006934 | Pride
Wisim-dia Lc-ms/ms Dia Wisim Dda Directdia 
ProteomicsInteractomes of GluA1 and GluA3 subunit containing AMPARs reveal distinct protein composition
The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. The most abundant AMPAR subtypes in the hippocampus are GluA1/2 and GluA2/3 heterotetramers. Each subtype contributes differentially to mechanisms of synaptic plasticity, which may be in pa...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD031603 | Pride
Proteomics Prrt1 Glua1/2 Tarp- γ8 Subcomplexes Ampar Glua2/3 Ms-dap 
ProteomicsCorrelation profiling of synaptic sub-fraction proteomes of the mouse brain hippocampus, cortex and cerebellum
Synaptic transmission forms the main mode of signaling and information integration in the nervous system. Here, we identified and quantified proteins from three brain regions and five biochemical synapse sub-fractions. We identified around 4500 proteins in total, of which about 2000 proteins each we...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-25 | PXD005634 | Pride
Post synaptic density Synapse Proteomics Correlation profiling 
ProteomicsComparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins
Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynam...
ORGANISM(S): marmosets Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-22 | PXD009251 | Pride
Synapse Species Proteomics Rat Marmoset Human Synaptosome Mouse Swath 
UnknownProstate motion in magnetic resonance imaging-guided radiotherapy and its impact on margins.
Not available
S-EPMC12283804 | biostudies-literature
UnknownNaturally occurring recombination in ferret coronaviruses revealed by complete genome characterization.
Not available
S-EPMC7079585 | biostudies-literature
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