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ProteomicsType 2 diabetes risk gene Dusp8 is a gatekeeper for hypothalamic Jnk signaling and insulin sensitivity
Recent genome-wide association studies (GWAS) identified Dusp8, a dual-specificity phosphatase targeting MAP kinases, as type 2 diabetes risk gene. Here, we unravel Dusp8 as gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male but not female Dusp8 loss-of-function m...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-17 | PXD019451 | Pride
Leptin Jnk Type2 diabetes Dusp8 
ProteomicsTranscriptional determinants of lipid mobilization in human adipocytes
Defects in white adipose tissue lipolysis drive multiple aspects of cardiometabolic disease but the transcriptional framework controlling this process has not been established. To address this, we performed a targeted perturbation screen in primary human adipocytes. Our analyses identified 37 transc...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD046964 | Pride
Coronary artery disease Lipolysis Type 2 diabetes Phosphodiesterase Znf189 Cad Pde1b2 T2dm Chip 
ProteomicsC-COMPASS: A user-friendly neural network tool profiles cell compartments at protein and lipid levels
Systematic proteomic organelle profiling methods including Protein Correlation Profiling and LOPIT have advanced our understanding of cellular compartmentalization. To manage the complexity of organelle profiling data, we introduce C-COMPASS, a user-friendly open-source software that employs a neura...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-07-18 | PXD056457 | Pride
Organelle proteomics 
ProteomicsEPAC1 enhances energy expenditure by selectively inducing brown and beige adipose tissue growth
Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure (EE) and cardiometabolic health. However, regulators that specifically increase the number of thermogenic adipocytes are still an unmet need. Here, we show by phosphoproteomics that cAMP activates distinct sig...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-11 | PXD046709 | Pride
Brown adipocyte Epac 
ProteomicsA network-based approach reveals a novel mechanism of resistance to TKI-therapy in AML
Internal tandem duplications (ITDs) in the FLT3 gene are frequently identified and confer a poor prognosis in patient affected by acute myeloid leukemia (AML). The insertion site of the ITDs in FLT3 significantly impacts the sensitivity to tyrosine kinase inhibitors (TKIs) therapy, affecting patient...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD033953 | Pride
Tyrosine kinase inhibitors Ba/f3 cells Acute myeloid leukemia Midostaurin Flt3 Mouse Phosphoproteomics Tki Quizartinib Aml 
ProteomicsA Spatiotemporal Proteomic Map of Human Adipogenesis
White adipocytes function as the major energy reservoir in humans by storing large amounts of triglycerides. Their dysfunction is associated with metabolic disorders. However, the mechanisms underlying cellular specialization during adipogenesis remain unknown. Here, we generated a spatiotemporal pr...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD047412 | Pride
Bcaa Slc25a10 Adipocyte Wat Sgbs Adipogenesis Pcp Proteomic ruler Ocm Mpan Organelle proteomics C19orf12 Human 
ProteomicsInsulin deficiency distorts human pancreatic endocrine cell composition during development
Objective: The developmental effects of mutations in genes associated with monogenic diabetes on human pancreas development is not well understood. More specifically, if insulin gene recessive mutations influence the human endocrine lineage segregation still needs to be investigated. Methods: W...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD045366 | Pride
Β cell Dia Monogenic diabetes Islet composition Insulin Ipsc differentiation Endocrinogenesis Lc-ms/ms 
ProteomicsGlobal, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice
The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic 𝛽-cells12. Yet, the relevance of 𝛽-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demons...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD046256 | Pride
Insulin inhibitory receptor Inceptor Insulin inceptor Diet-induced obesity Glucose homeostasis 
ProteomicsFunctional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator
Insulin regulates adipocyte biology partly by modulating gene expression, still many insulin-responsive targets remain uncharacterized. Here, we integrate three transcriptomic datasets to define insulin-regulated genes and assess their functions in human adipocytes using a multiparametric lipid turn...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD072248 | Pride
Phosphoinositide lipase Lipolysis White adipose tissue Adipocyte Insulin action Lipogenesis Plcxd1 Lipid turnover 
ProteomicsCharting endocrine progenitors across species and organs
Hormone-producing cells in the pancreas and intestine regulate whole-body metabolism and are key targets for causal therapies for diabetes and obesity. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate disease mechanisms and develop im...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD076279 | Pride
Diabetes Ngn3 Pancreas Proteomics Endocrine progenitor Β-cells 
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