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ProteomicsAIFM1 KO and AIFM1del mutant HEK cell proteomics
Mitochondrial proteases regulate the dynamic properties of the organelle morphology and ensure functional plasticity at the cellular level. The metalloprotease OMA1 mediates constitutive and stress-inducible processing of its substrates in mitochondria, but the number of functionally characterized s...
ORGANISM(S): Homo sapiens (Human) 
2026-01-31 | PXD063602 | Pride
Aifm1 Mitochondrion Hek 
ProteomicsSILAC-based carbonate extraction of subcellular fraction ER
Mitochondria dynamically adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limit mitochondrial fusion and promote mitochondrial stress signaling and metabolic rewiring. Here, we show that cellular stress a...
ORGANISM(S): Homo sapiens (Human) 
2025-12-19 | PXD070854 | Pride
Silac Carbonate extraction Er 
ProteomicsCycloheximide time course in WT and AFG3L2 knockout HeLa cells
Mitochondria are metabolically rewired in hypoxia when cells switch to glycolytic growth. In addition to the well-established role of transcriptional and translational programs, there is increasing evidence that post-translational mechanisms contribute to the rapid adaptation of the mitochondrial pr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD056318 | Pride
Cycloheximide Hela Mitochondria Afg3l2 
ProteomicsPHB1 and PHB2 deletion cell proteome
Folding of newly synthesized proteins poses challenges for a functional proteome. Dedicated protein quality control (PQC) systems promote either the folding of nascent polypeptides at ribosomes or, if this fails, ensure their degradation. While well studied for cytosolic protein biogenesis, it is no...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-08-14 | PXD043668 | Pride
Phb2 Yeast Label-free Phb1 Lc-ms/ms 
ProteomicsEnabling Routine MHC-II Associated Peptide ProteomicS (MAPPs) for Risk Assessment of Drug-Induced Immunogenicity
The appended raw files, csv files and other documents were deposited in the public domain in support for the publication Enabling Routine MHC-II Associated Peptide ProteomicS (MAPPs) for Risk Assessment of Drug-Induced Immunogenicity Guido Steiner, Celine Marban-Doran, Jessica Langer, Tatiana Pimeno...
ORGANISM(S): Custom Antibody Sequences Homo Sapiens (ncbitaxon:9606) 
2020-05-05 | MSV000085375 | MassIVE
ProteomicsProhibitin cross-linked aided interactome in yeast
The mitochondrial oxidative phosphorylation system (OXPHOS) contains subunits of dual genetic origin, namely the nuclear and the mitochondrial genome. Mounting the different subunits into functional OXPHOS complexes is aided by dedicated chaperones termed assembly factors. How unfunctional or superf...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-08-14 | PXD039717 | Pride
Phb2 Phb1 Dsg Yeast 
ProteomicsDisturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling
Lipid transfer proteins of the Ups1/PRELID1 family facilitate the transport of phospholipids across the intermembrane space of mitochondria in a lipid-specific manner. Heterodimeric complexes of yeast Ups1/Mdm35 or human PRELID1/TRIAP1 shuttle phosphatidic acid (PA) synthesized in the endoplasmic re...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-01-22 | PXD022321 | Pride
Yeast Usp1 Mitochondrion 
ProteomicsNeo N-termiome of SPG7, AFG3L2, SPG7 AFG3L2 and WT HeLa cells
To understand how OMA1 affects mitochondrial proteostasis and stress responses, we performed a proteomic survey of OMA1-deficient cells for proteolytic substrates. We demonstrate that OMA1 cleaves the mitochondrial chaperone DNAJC15 facilitating its degradation by the mitochondrial m-AAA protease. T...
ORGANISM(S): Homo sapiens (Human) 
2025-12-19 | PXD061137 | Pride
Human Neon Spg7 Hela Afg3l2 
ProteomicsNeo N termiome of Oma1 and WT knockout HeLa cells
To understand how OMA1 affects mitochondrial proteostasis and stress responses, we performed a proteomic survey of OMA1-deficient cells for proteolytic substrates. We demonstrate that OMA1 cleaves the mitochondrial chaperone DNAJC15 facilitating its degradation by the mitochondrial m-AAA protease. T...
ORGANISM(S): Homo sapiens (Human) 
2025-12-19 | PXD061134 | Pride
Neon Hela Oma1 
ProteomicsYME1L1 KnockOut MEF Cells Whole Proteomics
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remained enigmatic. We found that mtDNA-dependent immune signaling via the cGAS-STING pathway is under metabolic control and induced by cellular nucleotide deficien...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-27 | PXD018097 | Pride
Isg Yme1l1 Yme1l Mef cells 
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