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ProteomicsProteomics analysis of Medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children. It is a neuroectodermal tumor located in the cerebellum. International consensus recognizes four distinct subgroups of MBs including Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3), and Group 4 (G4) with distinct molecular...
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD053458 | Pride
Proteomics Multi-omics Cerebellum Medulloblastoma Metabolism. Pediatric brain tumor Phosphoproteomics 
ProteomicsPhosphoproteomics analysis of Medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children. It is a neuroectodermal tumor located in the cerebellum. International consensus recognizes four distinct subgroups of MBs including Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3), and Group 4 (G4) with distinct molecular...
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD053675 | Pride
Proteomics Multi-omics Cerebellum Medulloblastoma Metabolism. Pediatric brain tumor Phosphoproteomics 
ProteomicsCharacterization of hybrid cells in glioblastoma to better understand the plasticity that could lead to resistance to therapy
Cell subtype characterization by comparing cytoplasm and nucleus compartments
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD050217 | Pride
Proteomics 
ProteomicsIdentification of CTPS1 partners
Identify CTPS1 partners obtained by immunoprecipitation of a GFP-CTPS1 fusion protein (N-terminal tag) expressed in the HEK 293T cell line.
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD047654 | Pride
Gfp tag Hek Ctps1 
ProteomicsInvolvement of the microenvironment in the VC-Resist glioblastoma cells
In order to understand which molecular mechanisms are involved in radiation resistance and tumor propagation of glioblastoma, our laboratory has developed in-vitro models capable of mimicking the perivascular niche. Indeed, our laboratory hypothesizes that this niche is essential for glioblastoma ce...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-01-23 | PXD042606 | Pride
Perivasculaire niche Therapy Phosphoproteins Resistance 
ProteomicsFibroblast-tracks are topographical cues that direct cancer cell migration
Fibroblasts rely on adhesive structures to migrate. It is generally thought that adhesive structures disassemble once at the rear of the cell to release the cell and allow further movement. However, a significant portion of adhesions is not disassembled and is instead left on the substrate. We obser...
ORGANISM(S): Homo sapiens (Human) 
2023-09-22 | PXD034091 | Pride
Cancer Cafs Extracellular matrix 
ProteomicsGrowth factor induced desialylation for the fast control of endocytosis
It is commonly assumed that the glycan makeup of glycoproteins is final and static once these have reached the cell surface. Here, we discovered a molecular switch involving acute changes of glycans at the plasma membrane that challenges this notion. We demonstrate that growth factors tune within mi...
ORGANISM(S): Homo sapiens (Human) 
2024-11-29 | PXD041450 | Pride
Endocytosis Gal3 Sialylation Egfr 
ProteomicsPolQ peptide 4S-P (1482-P/86-P/88-P/93-P) binding partners identification
We characterized residus of PolQ which are phosphorylated during mitotis. We aimed to identify the partners of the phosphorylated residus of PolQ.
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD042167 | Pride
Polq Phosphorylation 
ProteomicsRelB function in lipid metabolism
Study of the role of the transcription factor RelB (alternative NF-kappaB subunit) in the control of lipid metabolism.
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD074627 | Pride
Hcc derived cell lines 
ProteomicsMitotic Hela cells expressing GFP-Mitotic Hela cells expressing GFP-Polθ vs Mitotic Hela cells expressing GFP-Polθ treated with Volasertib vs Mitotic Hela cells expressing GFP-Polθ treated with Volasertib
We show that Polθ is recruited to mitotic Double-strand breaks (DSBs) to slow down cell cycle progression and allow DNA repair. Because Polθ is one of the only repair protein to forms repair foci during mitosis, we investigated its regulation during mitosis. We performed immunoprecipitation (IP) of ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD036486 | Pride
Mitosis Plk1 Polθ 
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