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ProteomicsPlasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp, the causative agent of malaria is a divergent unicellular haploid eukaryote with some unusual features...
ORGANISM(S): Plasmodium berghei ANKA 
2024-08-08 | PXD053559 | Pride
Plasmodium Warwick_rtp Nek1 
ProteomicsA divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis
Meiosis is a conserved yet evolutionarily varied process that underpins sexual reproduction in eukaryotes. In the malaria parasite Plasmodium, meiosis occurs within the mosquito midgut immediately after fertilisation, as the diploid zygote differentiates into a motile ookinete. Here, we identify the...
ORGANISM(S): Plasmodium berghei ANKA 
2026-04-16 | PXD070161 | Pride
Plasmodium Nima-related kinase Malaria Ookinete Warwick_rtp Zygote Microtubules Mtoc Meiosis Chromosome 
ProteomicsPlasmodium berghei zygotes of WT and Pbnek4-ko lines at 0 and 2 hpa phosphoproteomics
Meiosis is a conserved yet evolutionarily varied process that underpins sexual reproduction in eukaryotes. In the malaria parasite Plasmodium, meiosis occurs within the mosquito midgut immediately after fertilisation, as the diploid zygote differentiates into a motile ookinete. Here, we identify the...
ORGANISM(S): Plasmodium berghei ANKA 
2026-04-16 | PXD070965 | Pride
Plasmodium berghei Nek4 Zygote Phosphoproteomics Meiosis 
ProteomicsDivergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut is initiated by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by three divergent male-specific protein kinases (PKs): CDPK4, SRP...
ORGANISM(S): Plasmodium berghei ANKA 
2025-03-18 | PXD061651 | Pride
Plasmodium Warwick_rtp Axoneme Mtoc Gametogenesis Kinetochore Kinase 
ProteomicsReal-time dynamics of Plasmodium Ndc80 reveals unusual modes of chromosome segregation during parasite proliferative stages
Eukaryotic cell proliferation requires chromosome replication and precise segregation to ensure daughter cells have identical genomic copies. The genus Plasmodium, the causative agent of malaria, has developed remarkable characteristic of nuclear division throughout its lifecycle to meet some peculi...
ORGANISM(S): Plasmodium berghei ANKA 
2020-06-09 | PXD017619 | Pride
Ndc80 Chromosome segregation Malaria Parasite Proliferation Warwick-rtp Plasmodium 
ProteomicsProtein Phosphatase 1 regulates atypical chromosome segregation and cell polarity during mitotic and meiotic division in Plasmodium sexual stages
PP1 is a conserved eukaryotic serine/threonine phosphatase that regulates many aspects of mitosis and meiosis, often working in concert with other phosphatases, such as CDC14 and CDC25. The proliferative stages of the parasite life cycle include sexual development within the mosquito vector, with ma...
ORGANISM(S): Plasmodium berghei ANKA 
2021-09-10 | PXD023571 | Pride
Cell division Kinetochore Phosphatase Polarity Sexual stage Warwick-rtp Plasmodium 
ProteomicsPlasmodium ARK2 and EB1 drives the unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein scaffolds. Plasmodium spp., the causative agents of malaria, are unicellular eukaryotes with three unique and ...
ORGANISM(S): Plasmodium berghei ANKA 
2023-08-15 | PXD043164 | Pride
Plasmodium Warwick_rtp Ark2 Eb1 
ProteomicsA divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of Plasmodium berghei during gametogony and parasite transmission.
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdepende...
ORGANISM(S): Plasmodium berghei ANKA 
2020-06-17 | PXD017622 | Pride
Malaria Parasite Cyclin Kinase Warwick-rtp Cyclin-dependent Plasmodium 
ProteomicsPlasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. During schizogony, asynchronous nuclear replication produces a...
ORGANISM(S): Plasmodium berghei ANKA 
2026-01-13 | PXD068821 | Pride
Male gametogony Plasmodium Aurora kinase Cytokinesis Warwick_rtp Spindle Chromosomal passenger complex (cpc) Incenp Karyokinesis Mtoc Transmission 
ProteomicsPlasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear. Here we examine the role of SMC2 and SMC4, the core subunits of co...
ORGANISM(S): Plasmodium berghei ANKA 
2020-05-27 | PXD016833 | Pride
Condensin Malaria Parasite Lc-ms Scm2 Warwick-rtp Plasmodium berghei Scm4 
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