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ProteomicsAcidosis attenuates the hypoxic stabilization of HIF-1α by activating its lysosomal degradation
The adaptive responses to oxygen depletion orchestrated by hypoxia-inducible factors (HIFs) produce profound effects on multiple pathways. A canonical metabolic response is enhanced fermentation, but this can generate an unfavorably acidic environment under poor capillary perfusion. It is unclear ho...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD062474 | Pride
Acidosis Colorectal cancer Hypoxia inducible factor Hypoxia Tumour microenvironment Sw1222 
ProteomicsRASSF1A IS REQUIRED FOR THE MAINTENANCE OF NUCLEAR ACTIN LEVELS
Nuclear actin participates in many essential cellular processes including gene transcription, chromatic remodelling and mRNA processing. Actin shuttles into and out the nucleus through the action of dedicated transport receptors importin-9 and exportin-6, but how this transport is regulated remains ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD011517 | Pride
Nuclear actin Nucleocytoplasmic shuttling Mst2 Nuclear envelope Rassf1a Exportin-6 Nuclear export Srf Mrtf-a 
ProteomicsRASSF1A controls Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
Lung cancer remains the leading cause of cancer-related death due to poor treatment responses and resistance arising from tumor heterogeneity. Here we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to increased deposition of extracellular mat...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012694 | Pride
Cancer stem cells Hippo pathway Extracellular matrix. Stiffness 
ProteomicsA truncated MRE11 form induced by SPRTN is deficient in DNA repair and radiosensitises cancer cells
he human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses 3’-5’ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associated with...
ORGANISM(S): Homo sapiens (Human) 
2021-02-23 | PXD017964 | Pride
C-terminal truncation Mre11 cleavage Mre11 Dna repair Sprtn 
ProteomicsTetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery
Due to its proximity to cells of the central nervous system, cerebrospinal fluid (CSF) is an important source of novel biomarkers for neurological diseases. Membrane-bound extracellular vesicles (EVs) are enriched for proteins of intracellular and membrane origin, implicated in the pathogenesis of s...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD061653 | Pride
Cerebrospinal fluid Proteomics Tetraspanin Extracellular vesicle Immunocapture. 
Proteomicsp97/VCP inhibition radiosensitises cancer cells through excessive MRE11-dependent DNA end resection
Cancer cells are under constant proteotoxic stress and have an increased genomic instability. They therefore rely on upregulation of protein homeostasis and the DNA damage response (DDR) for survival. The ubiquitin-dependent ATPase p97 is a central component of the ubiquitin-proteasome degradation s...
ORGANISM(S): Homo sapiens (Human) 
2021-05-18 | PXD016279 | Pride
Single-strand annealing Bladder cancer Dna double-strand break repair Proteasomal degradation Dna damage Ubiquitin Cb-5083 Homologous recombination Mre11 P97 
ProteomicsData-independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis
Unbiased proteomics of human cerebrospinal fluid (CSF) has been used successfully to identify biomarkers of Amyotrophic Lateral Sclerosis (ALS). However, high abundance proteins mask the presence of lower abundance proteins that may hold valuable diagnostic and prognostic use. Developments in mass s...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044274 | Pride
Amyotrophic lateral sclerosis Dia Csf Mass spectrometry Proteomics Biomarker 
ProteomicsSPARTAN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards Genome Stability
DNA-protein crosslinks (DPCs) are abundant DNA lesions, which constantly challenge genome stability by interfering with DNA replication. SPARTAN (SPRTN) protease plays a central role in DPCs repair in proliferative vertebrate cells. SPRTN is a constitutive part of the DNA replication machinery and i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006741 | Pride
Cancer Spartan protease Dna-protein crosslinks Ageing Genome stability Chk1 kinase Dna replication 
ProteomicsThe Bloom Syndrome Complex Senses RPA-Coated Single-Stranded DNA to Restart Stalled Replication Forks
The Bloom syndrome helicase BLM interacts with topoisomerase IIIa (TOP3A), RMI1 and RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non-crossover products during homologous recombination (HR). BLM also promotes DNA-end resection and stalled replication fork restart...
ORGANISM(S): Homo sapiens (Human) 
2021-01-05 | PXD018322 | Pride
Bloom syndrome Dna damage response Blm Rpa Homologous recombination Replication stress 
ProteomicsTDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord
Neuronal and glial cytoplasmic inclusions positive for TAR DNA-binding protein 43 (TDP-43) are the defining pathological hallmark of 97% of amyotrophic lateral sclerosis (ALS) and 50% of frontotemporal dementia (FTD). The ALS-FTD clinicopathological spectrum variably involves cortical and spinal ant...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD067060 | Pride
Proteomics Tissue Brain Tdp-43 Amyotrophic lateral sclerosis Spinal cord 
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