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ProteomicsEffect of LPS and the glucocorticoid dexamethasone on the mouse Bone Marrow Derived Macrophage Proteome
The concentrations and copy number of proteins in the mouse Bone Marrow Derived proteome was determined for control, 10 ng/mL LPS stimulation, and LPS stimulation plus the addition of 100 nM dexamethasone, after an incubation for 24 hours and with four biological replicates for each condition. Over ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD041375 | Pride
Innate immunity Glucocorticoid Macrophage Dexamethasone Mouse Type i interferon 
TranscriptomicsExpression profiles of primary bone marrow derived mouse macrophages M-bM-^@M-^S untreated and treated with LPS or LPS+PGE
The polarization of macrophages into an anti-inflammatory or regulatory phenotype plays an important role in resolving inflammation. PGE2 regulates macrophage polarization via a PKA dependent pathway. PKA phosphorylates SIKs, inhibiting their ability to phosphorylate CRTC3 in cells. This in turn ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-41833 | biostudies-arrayexpress
ProteomicsOptimising Spectronaut search parameters to improve data quality with minimal proteome coverage reductions in DIA analyses of heterogeneous samples
Data independent acquisition has seen breakthroughs that enable comprehensive proteome profiling using short gradients. As the proteome coverage continues to increase, the quality of the data generated becomes much more relevant. Using Spectronaut, we show that the default search parameters can be ...
ORGANISM(S): Candida albicans (Yeast) Mus musculus (Mouse) 
2023-10-11 | PXD045958 | Pride
Data quality Spectronaut False positives Immunology C. albicans Mouse Infection Dia Xic Multi-species 
UnknownTreating lymphoma is now a bit EZ-er.
Not available
S-EPMC8095133 | biostudies-literature
ProteomicsAPEX2 mediated proximity labeling to investigate the proximal proteome of mitochondria tethered ULK1 in wild type and fip200 knock down cells
The object of this project is to investigate the proximal proteome of ULK1 during mitophagy and the effects of a FIP200 knock down using the APEX2-mediated proximity labeling system. APEX2-ULK1 or APEX2 was fused to 2xFKBP-myc and stably expressed in a cell line stably expressing a truncated FIS1-FR...
ORGANISM(S): Homo sapiens (Human) 
2024-10-12 | PXD047277 | Pride
Fip200 Mitophagy Autophagy Frb-rapalog-fkbp interaction Ulk1 Apex2 Er 
ProteomicsCandida albicans infection suppresses Lipopolysaccharide or Pseudomonas aeruginosa stimulated murine bone marrow derived macrophage (BMDM) responses
Candida albicans is a commensal fungi which populates most healthy individuals’ microflora, but can turn opportunistic in immunocompromised individuals. This opportunistic pathogen can cause severe disease and is linked with high rates of mortality. With limited therapeutic options and increasing re...
ORGANISM(S): Candida albicans (Yeast) Mus musculus (Mouse) 
2026-03-16 | PXD062689 | Pride
Proteomics Bone marrow derived macrophages Co-infection P. aeruginosa infection C. albicans infection 
ProteomicsLipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation - Fluvastatin data
Naïve B cells exit quiescence and enter a proliferative state upon activation, ultimately differentiating into antibody-secreting or memory B cells. Toll-like receptor (TLR) ligands, such as lipopolysaccharide (LPS), can serve as physiological stimuli to initiate this transition. Using quantitative ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-18 | PXD074568 | Pride
ProteomicsBone marrow-derived mast cells +- IL-33 48h
Mast cells are tissue resident granulocytes which are most abundant at the interface between tissues and the external environment, such as around blood vessels, in the skin or mucosal surfaces in the lungs and gut. Pathologically they are involved in allergic reactions and anaphylaxis, however they ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD033759 | Pride
Granulocyte Mouse Lc-ms Mast cell Il-33 
ProteomicsDIA proteomic analysis of unstimulated murine bone marrow derived macrophages from WT, Nrf2 KO and Keap1 KD cells
Unstimulated murine bone marrow derived macrophages cultured in L92 media from WT (4 biological replicates), Nrf2 KO (3 biological replicates) and Keap1 KD BMDM (3 biological replicates) were processed and analysed utilising DIA (label free) proteomic analysis. The Nrf2 KO mouse (DOI: 10.1006/bbrc.1...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-01 | PXD030455 | Pride
Dia Keap1 Nrf2 Macrophages Bmdm Murine 
UnknownShared and distinct genetic features in human and canine B-cell lymphomas.
Not available
S-EPMC9198934 | biostudies-literature
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