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ProteomicsPhosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantit...
ORGANISM(S): Plasmodium falciparum 
2017-09-22 | PXD002266 | Pride
Malaria Quantitation Signalling Phosphorylation Parasite Invasion Protein kinase g Tandem mass tags 
ProteomicsSlowing prion disease via M1 muscarinic receptors is associated with reduced neuroinflammation and down-regulation of neurodegenerative disease markers
Currently there are no treatments that can slow or halt the progression of dementia’s including Alzheimer’s disease. Here we investigate the possibility that activation of the M1-muscarinic receptor (M1-receptor), which is highly expressed in the brain and that shows pro-cognitive properties, might ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-14 | PXD025561 | Pride
G protein-coupled receptor Alzheimer’s disease Neuroinflammation Warwick_rtp Positive allosteric modulators Transcriptomic Prion disease Proteomic Neurodegeneration Neurodegenerative disease M1 muscarinic acetylcholine receptor 
ProteomicsA divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis
Meiosis is a conserved yet evolutionarily varied process that underpins sexual reproduction in eukaryotes. In the malaria parasite Plasmodium, meiosis occurs within the mosquito midgut immediately after fertilisation, as the diploid zygote differentiates into a motile ookinete. Here, we identify the...
ORGANISM(S): Plasmodium berghei ANKA 
2026-04-16 | PXD070161 | Pride
Plasmodium Nima-related kinase Malaria Ookinete Warwick_rtp Zygote Microtubules Mtoc Meiosis Chromosome 
ProteomicsTransporter characterisation reveals aminoethylphosphonate mineralisation as a key step in the marine phosphorus redox cycle
The planktonic synthesis of reduced organophosphorus molecules, such as alkylphosphonates and aminophosphonates, represents one half of a vast global oceanic phosphorus redox cycle. Whilst alkylphosphonates tend to accumulate in recalcitrant dissolved organic matter, aminophosphonates do not. Thus, ...
ORGANISM(S): Stappia stellulata DSM 5886 Pseudomonas putida (strain BIRD-1) 
2021-09-07 | PXD026804 | Pride
Phosphorus redox cycle Transporter Proteomics Warwick-rtp Lcmsms 
ProteomicsPlasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. During schizogony, asynchronous nuclear replication produces a...
ORGANISM(S): Plasmodium berghei ANKA 
2026-01-13 | PXD068821 | Pride
Male gametogony Plasmodium Aurora kinase Cytokinesis Warwick_rtp Spindle Chromosomal passenger complex (cpc) Incenp Karyokinesis Mtoc Transmission 
ProteomicsMass spectrometry insights into a tandem ubiquitin‐binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
Unanchored polyubiquitin chains are emerging as important regulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin. However tools able to discriminate unanchored polyubiquitin chains of different isopeptide linkages have not been described. We desc...
ORGANISM(S): Homo sapiens (Human) 
2016-05-18 | PXD004059 | Pride
Ubiquitin Polyubiquitin 
ProteomicsA novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly divergent. Within 8 min, the haploid male gametocyte genome underg...
ORGANISM(S): Plasmodium berghei ANKA 
2025-05-19 | PXD062729 | Pride
Warwick_rtp 
ProteomicsNagA mediates the recycling of peptidoglycan derived amino sugars in mycobacteria
Many bacterial species are known to recover peptidoglycan (PG) fragments released from remodelling of their cell walls during growth and cell division. These PG fragments not only provide an essential energy resource, especially in nutrient restricted environments, but also play a critical role in i...
ORGANISM(S): Mycobacterium smegmatis 
2025-11-24 | PXD065120 | Pride
Warwick_rtp Peptidoglycan Naga Mycobacteria 
ProteomicsNovel mechanisms for phosphate acquisition in abundant rhizosphere-dwelling Bacteroidetes
Global food production is reliant on the application of finite phosphorus (P) fertilisers. Numerous negative consequences associated with intensive P fertilisation have resulted in a high demand to find alternative sustainable methods that will enhance crop P uptake. Bacteroidetes, primarily from th...
ORGANISM(S): Flavobacterium sp. 316 
2021-09-08 | PXD014380 | Pride
Exoproteomics Oilseed rape Bacteroidetes Rhizosphere 
ProteomicsCdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity, and cellular functions
Sam68 is a member of the STAR family of proteins that directly link signal transduction with post-transcriptional gene regulation. Sam68 controls the alternative splicing of many oncogenic proteins and its role is modulated by post-translational modifications, including serine/threonine phosphorylat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032716 | Pride
Warwick_rtp  sam68  khdrbs1 
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