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ProteomicsHuman Serum Immunoglobulin N-Glycosylation using nLC-MS/MS
Here we employ a nLC-MS/MS method to separate small amounts of purified immunoglobulins to characterize the N-glycan reportoire and site occupancy of bulk serum antibodies. Using this method, we have established, for the first time within individual donors, the N-linked glycan repotoire for bulk IgG...
ORGANISM(S): Homo sapiens (Human) 
2019-01-24 | PXD010911 | Pride
Human Igm Serum N-glycosylation Iga2 Iga1 Glycopeptides Igg1 Igg4 Immunoglobulins 
ProteomicsAltered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross‐Linking, MS/MS, and NMR
The endogenous cellular prion protein (PrPC) can misfold into the scrapie isoform (PrPSc) and cause fatal infectious diseases. Despite significant research on the prion protein, both its normal function and whether alterations to that function play a critical role in prion diseases remain unknown. T...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-16 | PXD012427 | Pride
Cross-linking Inter-domain protein interaction Mass spectrometry Prion 
ProteomicsO-fucosylated glycoproteins of Toxoplasma gondii
The fucose-binding Aleuria aurantia lectin (AAL) labels punctiform structures in proximity to the nuclei of Toxoplasma gondii tachyzoites. We have utilized AAL-lectin affinity purification in conjunction with LC MS/MS to identify a set of proteins modified with fucose on serines and threonines
ORGANISM(S): Toxoplasma gondii 
2016-10-11 | PXD004426 | Pride
Lc ms/ms Aal Affinity purification Fucose Nucleus Toxoplasma gondii Lectin 
ProteomicsLC-MS/MS data for HCA mRNA antibodies
Fc N-glycosylation of IgGs is necessary for effector functions and is a crucial component of quality control. Fc N-glycan profiles of HCA produced by two platforms were determined using mass spectrometry which revealed major differences in site occupancy, glycan types, and glycoform distribution.
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047910 | Pride
Glycosylation Igg Lc-ms/ms 
ProteomicsIdentification of In Vivo HLA-DR-Presented Self-Peptides (T Cell Epitopes) in Synovial Tissue, Synovial Fluid and Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis
HLA-DR molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory arthritides, including in rheumatoid arthritis (RA) and Lyme arthritis (LA). In the current study, we identified HLA-DR-presented self-peptides (T cell epitopes) in ST, synovial f...
ORGANISM(S): Homo sapiens (Human) 
2016-10-13 | PXD003051 | Pride
Synovial tissue Synovial fluid Human Peripheral blood Lc-ms/ms 
ProteomicsLC-MS/MS data of Extracellular Vimentin
Angiotensin-converting enzyme 2 (ACE2) has been identified as a key entry receptor for SARS-CoV-2. The involvement of other cellular components that partake in viral entry appears to be likely but is not yet fully understood. Here we describe the identification of vimentin (VIM), an intermediate fil...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD027595 | Pride
Sars-cov-2 receptor Sars-cov-2 Vimentin Spike protein Attachment factor 
ProteomicsVEGFR N-glycosylation
Vascular endothelial growth factor receptor-2 (VEGFR2) is a highly N-glycosylated receptor tyrosine kinase involved in pro-angiogenic signaling in physiological and pathological contexts, including cancer. VEGFR2 post-translational modifications (PTMs) and their roles in receptor function and signal...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-08 | PXD012629 | Pride
Vegfr2 Rtk N-glycosylation Nlc-ms/ms Mouse Glycopeptides 
ProteomicsGlycoproteoforms of Integrins α2 and β1 in Megakaryocytes in the Occurrence of Primary Myelofibrosis
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm prone to leukemic transformation, for which limited treatment is available. Amongst individuals diagnosed with PMF, the most prevalent mutation is the JAK2V617F somatic point mutation that activates the Janus kinase 2 (JAK2) enzyme. Our ea...
ORGANISM(S): Mesocricetus auratus (Golden hamster) Mus musculus (Mouse) 
2022-02-22 | PXD030550 | Pride
Integrins  megakaryocytes  primary myelofibrosis  lc-ms/ms  glycopeptiforms 
ProteomicsPost-translational modifications of vaccine candidates of Cryptosporidium parvum
Here we describe the post translational modifications on vaccine candidate proteins from Cryptosporidium parvum. We have identified O-glycosylated peptides from GP15, GP40, GP900, and a novel mucin-like protein referred to as GP20. In addition, we have discovered that the immune dominant antigen, C...
ORGANISM(S): Cryptosporidium parvum 
2017-08-14 | PXD005989 | Pride
Cryptosporidium parvum Lipopeptides Vaccine candidates Glycopeptides Lc-ms/ms 
ProteomicsN-Glycosylation of the Epidermal Growth Factor Receptor (EGFR) Derived from Human Oral Squamous Carcinoma Cells with beta-Catenin/CREB-Binding Protein (CBP) Inhibition
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in the world; oral squamous cell carcinomas (OSCC) account for the majority of HNSCC cases. A major driver of OSCC is the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK) with 12 N-glycosylatio...
ORGANISM(S): Homo sapiens (Human) 
2020-03-26 | PXD017060 | Pride
Human Beta-catenin/cbp inhibition Head and neck cancer Glycoproteomics Hsc-3 Glycopeptide Oral squamous cell carcinoma Oscc Egfr Lc-ms/ms Epidermal growth factor receptor Creb-binding protein Cal27 
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