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ProteomicsRAS-p110α signalling pathway in macrophages and its impact on both the initiation and resolution of inflammation
This study presents a secretome analysis of bone marrow-derived macrophages (BMDMs) from wild-type (WT) and RAS-p110α-disrupted macrophages. Samples were collected under both unstimulated conditions and during phagocytosis of apoptotic cells. The aim was to identify differential regulatory factors s...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-28 | PXD057794 | Pride
Proteomics Inflammation Macrophages Ras-pi3k Lc-ms/ms 
ProteomicsChemical phosphoproteomics reveals kinase network topologies associated to genotypes and phenotypes of cancer cells.
We compare the in vitro specificity profiles of several kinase inhibitors with their effects on cellular phosphoproteomes. For this aim, we developed an algorithm which utilizes information on kinase inhibitor selectivity to determine the most probable kinase(s) acting upstream of phosphorylation si...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-22 | MSV000090571 | MassIVE
ProteomicsTargeted therapy for LIMD1-deficient non-small cell lung cancer subtypes: a Proof-of-Concept synthetic lethal study
An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which binds multiple binding partners to suppress tumourigenesis via a number of different mechanisms. Approximately 45% of non-small cell lung cancers (NSCLC) ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023674 | Pride
Limd1 Tumour suppressor Synthetic lethality Nsclc Targeted therapy Lung cancer 
ProteomicsComputational analysis of cholangiocarcinoma phosphoproteomes identifies patient-specific drug targets
We used mass-spectrometry based phosphoproteomics and computational methods to identify patient-specific drug targets in primary CCA and CCA-derived cell lines. We analyzed 13 primary CCA with matched background tissue and 8 different cell lines leading to the identification and quantification of >1...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027329 | Pride
Cholangiocarcinoma 
ProteomicsCell rearrangement during angiogenesis requires suppression of actomyosin at cell-cell contacts via PI3-kinase.
Sprouting angiogenesis is a highly dynamic process which relies on the continuous interchange of endothelial cell relative position within the vascular sprout, a process mediated by cell rearrangements. Here we take advantage of a previous identified role of p110a/PI3K regulating endothelial cell mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD007060 | Pride
Mascot Pescal Phosphoproteomics Qexactive-plus Mice 
ProteomicsMicrotubule associated proteins MAP7 and MAP7D1 promote 53BP1-mediated DNA double strand break repair in G1 cell cycle phase
In this project we have been looking for proteins binding to phosphorylated sites in DNA repair proteins. Previously, we and others have used peptide-pull down assays as a direct means of attributing specific binding functions to known sites phosphorylated by CK2 in DDR proteins. We have now applied...
ORGANISM(S): Homo sapiens (Human) 
2023-03-01 | PXD033715 | Pride
Brca1 Dna damage repair Proteomics Xpc G1 cell cycle phase 53bp1 Map7 Map7d1 Rad50 Mlh1 Lc-ms/ms 
ProteomicsHuman omentum from patients with High-grade serous ovarian cancer
High-resolution multi-layered profiling of human ovarian cancer metastases.
ORGANISM(S): Homo sapiens (Human) 
2018-02-20 | PXD004060 | Pride
Lc-ms/ms Human Ovarian cancer Matrisome Extracellular matrix 
ProteomicsUnfolded Protein Response governs an Alternative Splicing program conserved from healthy to malignant cells
The unfolded protein response (UPR) is a critical adaptive program triggered upon cellular stresses that profoundly reshapes the transcriptome and translatome. In the very first minutes of cellular stress, translation blockage, RNA decay and RNA granules formation prompt the synthesis of proteins es...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD046476 | Pride
Perk Er stress Alternative splicing Unfolded protein response Translation 
ProteomicsAn increase in oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells with acquired resistance to PI3K/mTOR inhibitors
Proteomics and phosphoproteomics analysis of MCF7 cells sensitive and resistant to the PI3K inhibitor GDC-0941. The analysis was done for parental and 3 resistant cell lines maintained in the presence or the absence of the drug. One of the resistant cell lines (G2) was also treated with vehicle or t...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD003594 | Pride
Human Phosphoproteomics Metabolism Ltq-orbitrap Tio2 Pi3k resistance Q-exactive plus 
ProteomicsPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in AML cells
Background The p21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a lim...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056514 | Pride
Acute myeloid leukaemia Phosphoproteomics Machine learning Kinase inhibitors Pak inhibitors Target therapy Pf-3758309 Proteomics Biomarkers Cancer 
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