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ProteomicsProtein acetylation in young versus midlife Drosophila male heads
Old age is associated with a progressive decline of mitochondrial function and changes in nuclear chromatin. However, little is known about how metabolic activity and epigenetic modifications change as organisms reach their midlife. Here, we assessed how protein acetylation changes during midlife in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-01-22 | PXD003318 | Pride
Ageing Drosophila Protein acetylation 
ProteomicsMassive histone H3 phosphorylation without mitotic chromosome condensation
Histone post-translation modifications change dramatically as cells enter mitosis, Indeed, histone phosphorylation and deacetylation have been proposed to be major factors driving the compaction of mitotic chromosomes. However, whether these modification changes directly regulate mitotic chromatin c...
ORGANISM(S): Gallus gallus (Chicken) 
2026-09-22 | PXD078615 | Pride
Cell cycle Mitotic-like chromosomes Premature chromosome condensation Histone modifications 
ProteomicsA cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation
To understand the underlying molecular mechanism of Hdac9-mediated inflammasome activation and motivated by the molecular scaffolding function of HDAC9, we pursued the hypothesis that HDAC9 may serve as a docking site for cytosolic inflammasome components thereby facilitating its rapid formation upo...
ORGANISM(S): Homo sapiens (Human) 
2025-07-10 | PXD042078 | Pride
Inflammation Inflammasome Atherosclerosis Hdac9 Nlrp3 
ProteomicsAnalysis of cryopreservation of human granulosa cells
Human primary granulosa cells (GCs) derived from women, undergoing oocyte retrieval, can be cultured and are a cellular model for the study of human ovarian functions. In vitro they change rapidly, resembling initially cells of the preovulatory follicle and then cells of the corpus luteum. They are ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-28 | PXD025632 | Pride
Mass spectrometry Ivf Cell culture Progesterone Ovarian cells Cryopreservation 
ProteomicsThe role of methylation in egress and motility initiation in Toxoplasma gondii
Apicomplexan parasites such as Toxoplasma gondii depend on finely tuned cytoskeletal dynamics to invade and exit host cells. A central structure in this process is the conoid, a dynamic apical microtubule-based scaffold that integrates signalling and structural cues to initiate motility. While the l...
ORGANISM(S): Toxoplasma gondii RH 
2026-08-24 | PXD067879 | Pride
Akmt Toxoplasma gondii Motility initiation Apical methylation Pckmt 
ProteomicsIdentification of formaldehyde-induced DNA-protein crosslinks by PxP-MS
Compromised enzymatic actions, reactive metabolites, and various chemotherapeutics cause toxic covalent DNA-protein crosslinks (DPCs). Failure to repair DPCs results in genomic instability, premature aging, and tumorigenesis. However, understanding the principles underlying DPC formation and repair ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-20 | PXD026654 | Pride
Formaldehyde Pxp Dna-protein crosslinks Sprtn 
ProteomicsMitochondrial dynamics in ovarian granulosa cells during follicular growth and in human KGN cells
In the ovary, proliferation and differentiation of granulosa cells (GCs) drive the growth of follicles. This is, in part, dependent on gonadotropins. Our immunohistochemical studies provided hints of mitochondrial biogenesis and intracellular redistribution in GCs of growing follicles. A cellular mo...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032160 | Pride
Mitochondrial dynamics Ovary Forskolin Camp Kgn Granulosa cells 
ProteomicsAnalysis of histone PTMs in nascent chromatin in new and old histones upon DNA damage (CAL353, CAL358) using the NCC-SILAC approach
Dynamic recycling and de novo deposition of histones are fundamental for chromatin restoration. Histone post-translational modifications (PTMs) are assumed to have a causal role in establishing distinct chromatin structures. However, it remains unknown how specific histone PTMs are regulated at brok...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD018220 | Pride
Ncc Histone ptms Silac Camptothecin Replication 
ProteomicsAnalysis of innate immune antagonism by SARS-CoV-2 reveals options for therapeutic immune modulation and differences to SARS-CoV
The novel coronavirus SARS-CoV-2 has rapidly caused a global pandemic, due to higher transmission rates and lower mortality than previous epidemic CoVs. Here, we systematically analysed changes in the proteome of HEK293 cells upon overexpression of key SARS-CoV-2 encoded proteins and compared them ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2021-06-23 | PXD021899 | Pride
Sars-cov2 Innate immune system 
ProteomicsSAMD1 suppresses epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma.
SAMD1, a CpG island-binding protein, plays a pivotal role in the repression of its target genes by influencing the activity of KDM1A. Despite its significant correlation with outcomes in various tumor types, SAMD1's role in cancer has remained largely unexplored. In this study, we focus on pancreati...
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD044104 | Pride
Cancer Epithelial-mesenchymal transition Cpg islands N-cadherin Fbxo11 Samd1 Kdm1a Chromatin Pancreatic ductal adenocarcinoma 
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