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ProteomicsCryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals new features of arthritogenic alphaviruses
Characterize the glycosylation sites in E1 and E2, which are transmembrane proteins that are organized in heterodimers.
ORGANISM(S): Homo sapiens (Human) Mayaro virus (strain Brazil) 
2021-05-28 | PXD024432 | Pride
Cryo-em structure  alphaviruses  mass spectrometry  glycosylation 
ProteomicsReductionist approach using primary and metastatic cell-derived extracellular vesicles prospect proteins associated with oral cancer prognosis
Oral squamous cell carcinoma (OSCC) shows high mortality rates that are largely associated with the presence of lymph node metastasis. However, the molecular mechanisms that drive OSCC metastasis are unknown. Here, we used a reductionist approach mapping the proteomic, miRNA, metabolomic and lipidom...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD019216 | Pride
Metabolomics Mirna Multi-omics approach Lipidomics Lymph node metastasis Extracellular vesicles Oral cancer squamous cell carcinoma Proteomics Prognosis 
ProteomicsDifferent biological effects of exposure to far-UVC (222 nm) and near-UVC (254 nm) irradiation
Ultraviolet C (UVC) light has long been used as a sterilizing agent, primarily through devices that emit at 254 nm. Depending on the dose and duration of exposure, UV 254 nm can cause erythema and photokeratitis and potentially cause skin cancer since it directly modifies nitrogenated nucleic acid b...
ORGANISM(S): Homo sapiens (Human) 
2026-02-05 | PXD037726 | Pride
Uvc Irradiation Skin Germicidal lamp Hairless mice 
ProteomicsMapping the interactome of OSCC prognostic-associated proteins NDRG1 and PGK1 through proximity labeling using TurboID
Oral squamous cell carcinoma (OSCC) is a prevalent type of head and neck cancer, accounting for more than 90% of all oral malignancies worldwide. The identification of diagnostic and prognostic markers for OSCC is crucial for improving patient outcomes, as early detection and treatment are critical ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048046 | Pride
Ndrg1 Oral cancer Pgk1 Turboid Interactome Proximity labeling Prognostic 
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
We have demonstrated that site-directed mutagenesis in ADAM17 (ADAM17cytoF730A) also disrupts the interacting interface with Trx-1, resulting in a decrease of Trx-1 reductive capacity and activity. One of the mechanisms that explain this effect might be that ADAM17cyto favors Trx-1 monomerization st...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD015431 | Pride
Adam17 Thioredoxin-1 Mass spectrometry Redox signaling. Dimerization Iodotmt 
ProteomicsProteomic analysis of extracellular vesicles and cells
Extracellular vesicles and cells isolated from primary cells were submitted to mass spectrometry analysis.
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD023259 | Pride
Extracellular vesicles  primary cells  mass spectrometry 
ProteomicsLimited proteolysis-mass spectrometry of saliva maps proteome-wide structural changes associated with oral cancer aggressiveness.
Considering that these potential diagnostic and prognostic targets may be regulated by events that do not imply variation in protein abundance levels, we investigated the hypothesis that changes in protein conformation can be associated with diagnosis and prognosis, revealing biological processes an...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD042574 | Pride
Oral cance Limited proteolysis Saliva Functional proteomics Mass spectrometry Structural proteomic Protein post-translational modification Prognosis 
ProteomicsConnecting multiple microenvironment proteomes uncovers the biology in head and neck cancer
The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-21 | PXD027780 | Pride
Machine learning Head and neck squamous cell carcinoma Buffy coat Saliva Mouth neoplasms Proteomics Lymph node metastasis Prognosis Immune system Biomarkers 
ProteomicsMeta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients
The relationship between the microbial changes with clinical-pathological outcomes are still far from being conclusive. Herein, we investigate the ability of metagenomics (MG) and metaproteomics (MP) saliva data in distinguishing C, L0 and L1 patients. For that, we combined two strategies using MG a...
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD022859 | Pride
Saliva Oral cancer diagnosis and prognosis Mass spectrometry Oral squamous cell carcinoma Oral microbiome 
ProteomicsFFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neopla...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD007232 | Pride
Lc-ms/ms Ffpe Oscc 
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