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ProteomicsOff-target responses in the HeLa proteome subsequent to transient plasmid transfection using SILAC
We report a significant differential expression of proteins, all of which are associated with a viral infection response typified by Interferon type I/II. Notably the upregulated proteins may affect several vital cellular processes, including cell cycle control, translation and post-translational m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-23 | MSV000079757 | MassIVE
ProteomicsStudy of reversible oxidation of thiol proteins after hexyl aminolevulinate mediated photodynamic therapy
This proteomic study This proteomic study focuses on the role of reversible thiol oxidation after hexyl aminolevulinate mediated PDT (HAL-PDT). The human epidermoid carcinoma cell line A431 was used as model system and red light as light source, a clinical relevant in vitro model. The light dose dep...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080866 | MassIVE
ProteomicsIdentification of adsorbing human plasma proteins on alginate gel beads
The biocompatibility of immunoisolation devices is a major challenge for their use in cellular therapies. Utilisation of alginate for the encapsulation of pancreatic islets as a potential cellular therapy for type 1 diabetes has shown to be limited in terms of long-term graft survival, due to perica...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD009135 | Pride
Alginate gel beads Biocompatibility Protein adsorption Proteomics 
ProteomicsProteomic analysis uncovers enhanced inflammatory pheno-type and distinct metabolic changes in IDH1 mutant glioma cells
Isocitrate dehydrogenase 1 (IDH1) mutations are key drivers of glioma biology, influenc-ing tumor aggressiveness and treatment response. To elucidate their molecular impact, we performed proteome analysis on patient-derived (PD) and U87MG glioma cell models with either mutant or wildtype IDH1. We qu...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD065327 | Pride
Dna repair Antigen presentation Glioma biomarkers Isocitrate dehydrogenase mutations Rna Dna and histone demethylases Proteomics Interferon signaling 
ProteomicsHistone deacetylase inhibitors mediate selective degradation of nuclear uracil-DNA glycosylase 2 and increased genomic uracil
HDAC inhibitors (HDACi) belong to a new group of chemotherapeutics that are increasingly used to treat B-cell-derived malignancies. Such malignancies regularly carry mutational signatures that conform to off-target induction of uracil by the AID/APOBEC family of cytidine deaminases, or downstream pr...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD008293 | Pride
Aa Amino acid  aid Activation induced deaminase; 
ProteomicsOxidative posttranslational modifications of cysteine are associated to high intrinsic aerobic capacity in the skeletal and cardiac muscle
Oxidative posttranslational modifications (Ox-PTMs) regulate cellular homeostasis in several tissues, including skeletal and cardiac muscles. The putative relationship between Ox-PTMs and intrinsic components of oxidative energy metabolism has not been previously described. We determined the metabol...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD009109 | Pride
Heart Ox-ptm Mdh1 Redox proteomics Exercise Icat Mitochondria Cysteine Cardiac Aerobic Skeleta Oxidation Oxidative stress Posttranslational modifications Muscle 
ProteomicsOff-target responses in the HeLa proteome subsequent to transient plasmid transfection using SILAC
We report a significant differential expression of proteins, all of which are associated with a viral infection response typified by Interferon type I/II. Notably the upregulated proteins may affect several vital cellular processes, including cell cycle control, translation and post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2014-12-08 | PXD001278 | Pride
Hela Proteome Plasmid Transfection Silac Off-target Responses Transient 
ProteomicsDifferential protein expression between Carfilzomib-sensitive (AMO1) and resistant (AMO1-CFZ) multiple myeloma cells
Carfilzomib-sensitive (AMO1) and resistant (AMO1-CFZ) MM cells were grown in RPMI-1640 medium supplemented with 10 % FBS and 0.68 mM L-glutamine, in a humidified incubator at 5% CO2 and 37 °C. The AMO1-CFZ medium was additionally added 90 nM CFZ, while the CFZ sensitive AMO1 cells were added vehicle...
ORGANISM(S): Homo sapiens (Human) 
2024-06-07 | PXD045439 | Pride
Myeloma 
ProteomicsStudy of reversible oxidation of thiol proteins after hexyl aminolevulinate mediated photodynamic therapy
This proteomic study This proteomic study focuses on the role of reversible thiol oxidation after hexyl aminolevulinate mediated PDT (HAL-PDT). The human epidermoid carcinoma cell line A431 was used as model system and red light as light source, a clinical relevant in vitro model. The light dose dep...
ORGANISM(S): Homo sapiens (Human) 
2016-01-12 | PXD001582 | Pride
Redox signalling Reactive oxygen species Photodynamic therapy Apoptosis Proteomic Reversible protein oxidation 
ProteomicsToxicoproteomic and lipidomic analysis of human lung cells chronically exposed to MWCNT
Multi-walled carbon nanotubes (MWCNT) present a wide variety of exciting application opportunities. As MWCNT are produced in large quantities, occupational exposure and human health is of particular concern. However, there is no consensus regarding their potential harmful effects. In particular, chr...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD005970 | Pride
Carbon nanotubes Lc-msms Genotoxicity Toxicoproteomics Lipidomics Label free quantification Long-term exposure Apoptosis Human Mwcnt 
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