Sort   by:  
 Page size 
ProteomicsPolyQ-expanded ataxin-1 formed insoluble protein inclusions perturbing translation in a spinocerebellar ataxia type-1 model
Spinocerebellar ataxia type-1 is caused by an abnormally expanded polyglutamine (polyQ) tract in ataxin-1 protein. These expansions are responsible for protein misfolding and self-assembly into intranuclear inclusion bodies (IIBs) that are linked to neuronal death. Here, we describe a nuclear protei...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD012709 | Pride
Ataxin-1 Sleeping beauty transposon Protein network Polyglutamine Afm Ribosome Nucleolus. Spinocerebellar ataxia type-1 Rna-seq 
ProteomicsThe Hidden Culprit of Visceral Fat: Dysfunctional Subcutaneous Adipose Tissue – Serum proteomics
To investigate the proteomic profiles of paired subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples, as well as their correlations with clinical traits in severely obese patients, and to identify potential serum protein markers associated with tissue expression or metabolic s...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041750 | Pride
Adipose tissue  visceral adipose tissue  subcutaneous adipose tissue  obesity  proteomics  type 2 diabetes  serum proteomics 
ProteomicsPhosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2
Abstract Primary cilia are organelles necessary for proper implementation of developmental and homeostasis processes. To initiate their assembly, coordinated actions of multiple proteins are needed. Tau tubulin kinase 2 (TTBK2) is a key player in the cilium assembly pathway, controlling final step o...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD014199 | Pride
Cep83 Cep89 Ccdc92 Mass spectrometry Phosphorylation Rabin8 Dvl3 Cep164 Ttbk2 
ProteomicsDDX21 is a p38-MAPK sensitive nucleolar protein necessary for mouse preimplantation embryo development and cell-fate specification
2-cell (E1.5) stage embryos were cultured in normal KSOM+AA conditions until E3.5 +2h and thereafter 100 embryos each were moved to control or p38-MAPKi conditions and cultured for another 7 hours (E3.5 +9h). The embryos were then washed through pre-warmed (37˚C) Hank’s balanced salt solution (HBSS,...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-12 | PXD025754 | Pride
Lc-msms Preimplantation embryo development Ddx21 Cell fate specification P38-mapk 
ProteomicsLinezolid suppresses growth of tumours dervived from triple negative breast cancer, cancer chemoresistant and cancer stem-like cells through the induction of mitochondrial dysfunction
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvirontment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC) is thought to be responsible for tumour recurrence. These consequences are fatal f...
ORGANISM(S): Homo sapiens (Human) 
2018-11-04 | PXD009442 | Pride
Autophagy Cancer stem cells Ros Cancer Therapy resistance Antibiotics Lc-ms/ms 
ProteomicsThe Hidden Culprit of Visceral Fat: Dysfunctional Subcutaneous Adipose Tissue – Adipose tissue proteomics
To investigate the proteomic profiles of paired subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples, as well as their correlations with clinical traits in severely obese patients, and to identify potential serum protein markers associated with tissue expression or metabolic s...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD041721 | Pride
Adipose tissue  visceral adipose tissue  subcutaneous adipose tissue  obesity  proteomics  type 2 diabetes 
ProteomicsA SMG7-eIF4A module constitutes a homeostatic system for P-bodies and Meiotic bodies
The nucleation of RNP granules requires the participation of mRNAs, which simultaneously as becoming their target, dictate their properties. Here we report that in Arabidopsis the RNA helicase eIF4A limits the condensation of P-bodies acting as an RNA chaperone, disassembled from the eIF4F complex. ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-03-25 | PXD061406 | Pride
Eif4a Stress granules P-bodies Eif4f Rnp granules Biomolecular condensates Smg7 Rna condensation Meiosis Meiotic bodies 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - LFQ proteome profiling to determine the impact of AAK1/BMP2K perturbation
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055831 | Pride
Focal adhesions Lc-ms Dia Aak1 Lfq Migration Bmp2k 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - AAK1 C-terminal interactome profiling – batch 1
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD056027 | Pride
Lc-ms Dia Co-immunoprecipitation Aak1 Interactomics 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - SILAC proteome profiling to determine the impact of acute AAK1/BMP2K inhibition
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055851 | Pride
Focal adhesions Lc-ms Silac Aak1 Migration Dda Bmp2k 
Sort   by:  
 Page size