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ProteomicsIdentification of glutamate receptor delta-1 interactome at synapses.
In this project, we have investigated the interactome of the glutamate receptor delta-1 (GluD1) in developing synapses in mice. GluD1 is a member of the delta subfamily of ionotropic glutamate receptors widely expressed in the brain. It behaves as a postsynaptic organizer by engaging in trans-synapt...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-06 | PXD010373 | Pride
Synapse Neuron Glutamate receptor Brain Grid1 Mouse 
ProteomicsShigella flexneri effectors IpaJ and VirA globally impair host conventional secretion
Intracellular trafficking pathways in eukaryotic cells are essential to maintain organelle identity and structure, and to regulate cell communication with its environment. Shigella flexneri invades and subverts the human colonic epithelium by the injection of virulence factors through a type 3 secre...
ORGANISM(S): Shigella flexneri 
2019-06-04 | PXD012291 | Pride
Secretion Ipaj Silac Bacteria Vira Pathogen Polarity 
ProteomicsMS on EVs from the YSL of 3dpf zebrafish embryos
We set up a zebrafish model to study EVs in vivo by light microscopy, using CD63-pHluorin as a marker. To verify if exosomes from zebrafish have a comparable composition as human exosomes, and to validate the use of CD63 as a marker, we first analysed the compositon of EVs isolated from in vitro cul...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-04-10 | PXD011258 | Pride
Ex vivo Exosomes Endogenous Zebrafish Ysl 
ProteomicsATIP3-interacting partners
ATIP3 is a Microtubule-Associated-Protein with potent anti-tumoral effects in breast cancer. To investigate the mechanisms of action of ATIP3, we have undertaken proteomic analyses to identify ATIP3-interacting partners
ORGANISM(S): Homo sapiens (Human) 
2020-08-18 | PXD009182 | Pride
Gfp Breast cancer Immunoprecipitation Mcf-7 cell line Gfp-atip3 
ProteomicsProteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
The extracellular vesicles (EVs) have become the focus of rising interest, because of their numerous functions in physiology and pathology. Cells release heterogeneous vesicles of different sizes and intracellular origins, including small EVs formed inside endosomal compartments (i.e. exosomes) and ...
ORGANISM(S): Homo sapiens (Human) 
2016-02-11 | PXD003257 | Pride
Ectosomes Microvesicles Exosomes Extracellular vesicles Dendritic cells 
ProteomicsEml1-associated proteins in mouse neural progenitors
Echinoderm microtubule (MT)-associated protein-like 1 (Eml1) is mutated in the HeCo mouse, which exhibits subcortical band heterotopia (SBH), a developmental malformation of the cerebral cortex. EML1 mutations are also found in human patients affected by severe ribbon-like heterotopia, associated wi...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-19 | PXD006837 | Pride
Neural progenitors Mouse Microtubules Eml1 Cortical development 
ProteomicsProteomic analysis of human Medulloblastoma reveals distinct activated pathways between subgroups
Deregulations in fundamental signaling pathways are key events in pathogenesis of cancer. One intriguing illustration that still holds blind spots is the pediatric brain tumor arising from the developing cerebellum: medulloblastoma (MB). Extensive high-throughput sequencing led to the characterizati...
ORGANISM(S): Homo sapiens (Human) 
2020-07-23 | PXD006607 | Pride
Multiomics Whole genome sequencing Rnaseq Medulloblastoma Proteomic Phosphoproteomic Methylome 
ProteomicsCD44 regulates epigenetic plasticity by mediating iron endocytosis - part 2
The biological process termed Epithelial-to-Mesenchymal Transition (EMT) plays a central role in cancer cell invasion, metastasis, self-renewal and resistance to therapy(1,2). Here, using western blot technique, we show that H3K9me2 decreases when MDA-MB-468 breast cancer cells undergo EMT upon EGF....
ORGANISM(S): Homo sapiens (Human) 
2010-10-09 | PXD012862 | Pride
Emt Ms/ms spectrum Histones Breast cancer 
ProteomicsSmall RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants
PIWI-interacting RNAs (piRNAs) promote fertility in many animals. Yet, whether this is due to their conserved role in repressing repetitive elements (REs) or other functions remains unclear. Here, we show that the progressive loss of fertility in Caenorhabditis elegans lacking piRNAs is not caused b...
ORGANISM(S): Caenorhabditis elegans 
2019-12-11 | PXD012557 | Pride
Wago-1 Caenorhabditis elegans Lc-ms/ms 
ProteomicsThe CENP-T/-W complex is a binding partner of the histone chaperone FACT
The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W is not inherited at centromeres and new deposition is absolutely required at...
ORGANISM(S): Homo sapiens (Human) 
2016-06-14 | PXD004099 | Pride
Centromere Cenp Mitosis Histone chaperone 
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