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ProteomicsArginine to Cysteine substitutants in lung cancer enhance survival to chemotherapy
Tryptophan and arginine are the two most prominent restrictive amino acids linked to anti-tumor activity. For tryptophan, the induction of indoleamine 2,3-dioxygenase 1 (IDO1) by interferon-gamma (IFNg) secreted by T cells, catabolizes tryptophan to kynurenine to suppress T cell activity. For argini...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043612 | Pride
Arginine Substituants Keap1 Lung cancer Tryptophan 
ProteomicsChemotherapy-induced codon-specific immunopeptidome diversification
Deregulated mRNA translation in cancer is a source of aberrant protein production when tryptophan shortage is induced by anti-tumor immunity (refs). Tryptophan is decoded by only one codon, and currently the consequences of aberrant protein production in conditions of a shortage of amino acids decod...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044085 | Pride
Aberrant protein Mrna translation Tryptophan Leucine Ribosomal stalling Immunopeptidomics Neoepitopes 
ProteomicsMULTIMODAL STIMULATION SCREENS REVEAL UNIQUE AND SHARED GENES LIMITING T-CELL FITNESS
T-cell dysfunction genes limit antitumor activity and may serve as therapeutic targets. It has not been systematically studied whether there are regulators that either uniquely or broadly contribute to T-cell fitness. We performed genome-scale CRISPR/Cas9 knockout screens in primary CD8 T-cells to u...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-16 | PXD043545 | Pride
T-cells Dap5 Exhaustion Ctbp1 Activation-induced cell death Crispr/cas9 screen Icam1 Effector function Cancer immunotherapy Dysfunction 
ProteomicsCDS2 is a synthetic lethal target in mesenchymal-like cancers
Synthetic lethal interactions (SLIs) based on genomic alterations in cancer have been therapeutically explored. We investigated the SLI space as a function of differential RNA expression in cancer and normal tissue. Computational analyses of functional genomic and gene expression resources uncovered...
ORGANISM(S): Homo sapiens (Human) 
2025-03-31 | PXD045833 | Pride
Synthetic lethal interactions Cds2 Dia Mesenchymal cancers Proteome Lc-ms/ms 
ProteomicsArginine deprivation of ASS1-deficient cancers drives mistranslation and shared neoepitope production
Arginine biosynthesis is frequently suppressed in human cancer due to loss of argininosuccinate synthetase 1 (ASS1) expression, rendering cancer cells reliant on extracellular arginine. This observation propelled the development of systemic arginine depletion strategies, which are clinically safe bu...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD068912 | Pride
ProteomicsPP2A inhibition instructs spliceosome phosphorylation patterns to create splicing vulnerability in colon adenocarcinoma
Protein phosphatase 2A (PP2A) is a promiscuous enzyme that acts on many aspects of cellular physiology. It remains unclear however, which of the cellular processes are most perturbed upon inhibition of PP2A and how such perturbations could be exploited therapeutically. Here, we report an unanticipat...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043658 | Pride
Pp2a inhibition Lb-100 Phosphorylation Colon adenocarcinoma Alternative splicing 
ProteomicsProteomic analysis identifies novel BRCA1-associated protein 1 binding proteins
BRCA1-associated protein 1 (BAP1) is a tumor suppressor and its loss can result in mesothelioma, uveal and cutaneous melanoma, clear cell renal cell carcinoma and bladder cancer. BAP1 is a deubiquitinating enzyme of the UCH class that has been implicated in various cellular processes like cell growt...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD023676 | Pride
Hela Ap-ms Bap1 Deubiquitination Lc-ms Proteomics 
ProteomicsOncogene-dependent sloppiness in mRNA translation
mRNA translation is a highly conserved and tightly-controlled mechanism for protein synthesis. However, despite protein quality control mechanisms, amino-acid shortage in melanoma induces aberrant proteins by ribosomal frameshifting. The extent and the underlying mechanisms related to this phenomeno...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD022707 | Pride
Ribosomal frameshifting Cancer Tryptophan depletion Immunoprecipitation Human Translation Lc-ms/ms 
ProteomicsUBIQUITIN LIGASE STUB1 DESTABILIZES IFNγ-RECEPTOR COMPLEX TO SUPPRESS TUMOR IFNγ SIGNALING
The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about 36 regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell sur...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD030580 | Pride
Immune checkpoint blockade Ubiquitination Ifnγ Stub1 Melanoma 
ProteomicsUBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168
Maintenance of genome integrity requires tight control of DNA damage signalling and repair activities at DNA lesions, as well as their restriction at telomeres. Key components of the mechanisms underlying appropriate responses to DNA damage include phosphorylation events by DNA damage response (DDR)...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-30 | PXD044410 | Pride
Molecular biology Non-homologous-end joining Rnf168 Dna damage and repair Ube2d3 Lc-msms Telomere 
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