Sort   by:  
 Page size 
ProteomicsProteomic analysis of integrin activation-state-dependent adhesion complexes
Proteomic analysis of integrin activation-state-dependent adhesion complexes. Adhesion complexes were isolated from K562 cells using activation-state-specific monoclonal antibodies coupled to magnetic beads.Tandem mass spectra were extracted using extract_msn (Thermo Fisher Scientific) executed in M...
ORGANISM(S): Homo sapiens (Human) 
2015-01-26 | PXD000155 | Pride
Human K562 Adhesion complex Integrin Activation state Ms Proteomics 
ProteomicsProteomic analysis of alpha4beta1 integrin adhesion complexes reveals alpha-subunit-dependent protein recruitment
Peptides and proteins identified for VCAM-1(D40A) control ligand affinity purification using K562-alpha4 cells (biological replicate 1)
ORGANISM(S): Homo sapiens (Human) 
2012-05-27 | PRD000565 | Pride
ProteomicsProteomic analysis of integrin adhesion complex-mediated mechanotransduction
Integrin adhesion complexes were isolated from mouse fibroblasts treated with or without blebbistatin. Adhesion complexes were resolved by SDS-PAGE, digested with trpysin and analysed by LC-MS/MS using an LTQ Velos mass spectrometer
ORGANISM(S): Mus musculus (Mouse) 
2015-10-19 | PXD000018 | Pride
Adhesion complex Mouse Integrin Fibroblast Lc-ms/ms 
ProteomicsProteomic analysis of ECM supporting hESC maintenance
Comparative analysis of extracellular matrix proteins in substrates supportive and unsupportive for human embryonic stem cell maintenance
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2013-05-30 | PRD000600 | Pride
ProteomicsCharacterisation of a nucleo-adhesome
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report th...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-01 | PXD025870 | Pride
Adhesome Adhesion Nucleus Human 
ProteomicsCharacterisation of a FAK-proximal nuclear interactome
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report th...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-01 | PXD025861 | Pride
Adhesion Nucleus Human Fak 
ProteomicsCharacterisation of a Hic-5-proximal nuclear interactome
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report th...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-01 | PXD025868 | Pride
Hic-5 Adhesion Nucleus Human 
ProteomicsCharacterisation of FAK- and ILK-dependent nuclear subproteomes
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report that nuclear prote...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD020179 | Pride
Cancer Ilk Adhesion Nucleus Human Fak 
ProteomicsProteomic analysis of IL33-proximal proteins in squamous cell carcinoma cells
Focal adhesion kinase (FAK) is required for the expression of pro-inflammatory genes that inhibit anti-tumour immunity. Here, we show a novel and crucial role for the dual-function cytokine IL33 in FAK-dependent immune evasion. Specifically, nuclear FAK is required for the expression of IL33, the ch...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-06 | PXD007698 | Pride
Fak Transcription Proteomics Tumour growth Lc-ms Il33 Il1rl1 Scc Bioid St2 Chromatin 
ProteomicsAmbra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic structures t...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD006002 | Pride
Ambra1 Ifitm3 Trafficking Invasion Src Fak Dynactin 1 
Sort   by:  
 Page size