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ProteomicsLight availability promotes distinct responses of plastid protein acetylation marks directed from the N-acetyltransferase GNAT2
Acetylation of amino groups is an important and recurrent protein modification in all eukaryotes. In plants, both lysine and N-terminal acetylation have additional important roles in protein regulation in chloroplasts. However, it is yet unclear how acetylation patterns respond to environmental stre...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-08-22 | PXD040235 | Pride
Gnat2 Acetylation Arabidopsis Light Thaliana Acetylome Proteomics Acetyltransferase Light acclimation Nta Quantitative Plastid Co- and post-translational modifications 
ProteomicsProteomic study of Naa20 inactivation in MEFs
This study focuses on the proteomic analysis of mouse embryonic fybroblasts where Naa20 can be inactivated, to observe its role in biological pathways and its effect on the N-terminal acetylation of proteins.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD029641 | Pride
Mef Mus musculus Proteome Acetylation N-terminal Naa20 
ProteomicsA continuous assay set to screen and characterize novel protein N-acetyltransferases unveils rice GNAT2 activity
Protein N-acetyltransferases (NATs) belong to the Gcn5-related N-acetyltransferases (GNATs) superfamily. GNATs catalyze the transfer of acetyl from acetyl-CoA to the reactive amine moiety of a wide range of acceptors. NAT sequences are difficult to distinguish from other members of the GNAT superfam...
ORGANISM(S): Escherichia coli Oryza sativa (Rice) 
2022-04-04 | PXD030189 | Pride
Rice Acetylation Yeast Modifications Nata N-acetyltransferase Gnat 
ProteomicsGlobal and protein-specific analysis reveals Nt-acetylation-independent turnover of SQE1 by Arabidopsis DOA10-like E3 ligases
The Acetylation-dependent (Ac/) N-degron pathway degrades proteins through recognition of their acetylated N-termini (Nt) by specific E3-ligases (Ac/N-recognins). To date, no Ac/N-recognins have been defined in plants. Here we use molecular, genetic, and multi-omics approaches to characterise potent...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-01-26 | PXD043217 | Pride
Erad Nt-acetylation Ac/n-degron pathway Sterol biosynthesis Proteolysis Ac/n-recognin N-terminomics 
ProteomicsNatB-Mediated N-Terminal Acetylation Regulates the UPS-Autophagy Interplay to Balance Plant Growth and Nutrient Starvation
N-acetylome analysis of WT and natb mutant lines; distribution for NTA yields of peptides starting
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-03-04 | PXD066411 | Pride
Arabidopsis Quantitative Silpronaq N-terminomics 
ProteomicsN-Acetylation of secreted proteins is widespread in Apicomplexa and independent of acetyl-CoA transporter AT1
Acetyl-CoA critically participates in post-translational modification of proteins, central carbon and lipid metabolism in several compartments of eukaryotic cells. In mammals, the acetyl-CoA transporter 1 (AT1) facilitates the flux of cytosolic acetyl-CoA into the endoplasmic reticulum (ER) enabling...
ORGANISM(S): Toxoplasma gondii Plasmodium berghei 
2022-06-20 | PXD029616 | Pride
Acetyl-coa transporter Toxoplasma gondii Endoplasmic reticulum Acetylome Secretory pathway Plasmodium berghei 
ProteomicsAtNAA50 behaviour in the core NatA complex
In eukaryotes, the N-terminal acetylation (NTA) is one of the most frequent protein modifications. In many organisms, and especially in plants, its biological function remains a mystery. In Arabidopsis thaliana, a large part of the proteome acetylation is catalyzed co-translationally by the action o...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Escherichia coli 
2020-07-15 | PXD017430 | Pride
Naa50 Arabidopsis Rosetta Ptm N-acetyltransferase Nata Gap Acetylation N-ter 
ProteomicsN-terminal acetylation in Arabidopsis thaliana, and the effects of Naa10/15 or HypK knock-outs
This project is about the study of the effects of several proteins on the proteome of Arabidopsis thaliana, and more specifically on the N-terminal acetylome of this plant. To this end were analysed KO samples of either an N-alpha acetyltransferase (Naa10 or Naa15) or the chaperonne protein HypK.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-12 | PXD023195 | Pride
Naa15 Proteomics Arabidopsis thaliana Mass spectrometry N-terminal acetylation Hypk Naa10 
ProteomicsArabidopsis thaliana N-terminal Acetylome
Quantitative study of the N-terminal acetylome variations in Arabidopsis thaliana, looking at the effect of a N-acetyltransferase KO.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-07-13 | PXD016496 | Pride
Nat Arbadiopsis Quantitation Acetylome N-termini Silpronaq 
ProteomicsHYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana
The ribosome-tethered N-terminal acetyltransferase A (NatA) acetylates 52% of soluble proteins in Arabidopsis thaliana. This co-translational shielding of the N-terminus stabilizes diverse cytosolic plant proteins. The Huntingtin yeast partner K (HYPK) facilitates NatA activity in planta, but in vit...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-01-22 | PXD043600 | Pride
Co-translational protein modification N-terminal acetylation Nata Hypk Drought resistance 
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