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ProteomicsDefinition of the fibroblast adhesome using multiplexed proximity biotinylation
Integrin adhesion complexes (IACs) bridge the extracellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mechanical cues. The composition, interactions, stoichiometry and topological organisation of proteins within IACs are not fully understood. To address ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD017241 | Pride
Fibroblast Adhesome Bioid 
ProteomicsProximity mapping of desmosomes reveals a striking maturation-dependent shift in their molecular neighbourhood
Desmosomes are multiprotein adhesion complexes that link intermediate filaments to the plasma membrane, ensuring the mechanical integrity of cells across tissues, but how they participate in the wider signalling network to exert their full function is unclear. To investigate this we performed multip...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-05-23 | PXD037933 | Pride
Adhesion Desmosome Bioid 
ProteomicsProximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families
Endocytic recycling controls the return of internalised cargos to the plasma membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classified as fast recycling from early endosomes (Rab4)...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD033693 | Pride
Bioid Human Rab11a Endocytosis Rab25 Rab4a 
ProteomicsThe IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix
The Fibroblastic Focus (FF) is a lesion typical of Idiopathic Pulmonary Fibrosis (IPF). It is the site of myofibroblast accumulation and extracellular matrix (ECM) production. The molecular composition and function of the FF and surrounding tissue remain undefined. Utilizing laser capture microdiss...
ORGANISM(S): Homo sapiens (Human) 
2022-08-31 | PXD029341 | Pride
Human Ipf Collagen Fibroblastic focus 
ProteomicsmicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD011882 | Pride
Mechanotransduction Mirna Human Homestasis Ago2 Stiffness Huvec 
ProteomicsMitochondrial antiviral-signalling protein is a client of the BAG6 QC complex
The heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-anchored (TA) membrane proteins from an SGTA-bound preloading complex to the endoplasmic reticulum (ER) delivery component TRC40. In contrast, defective precursors, including aberrant TA proteins, form a stable...
ORGANISM(S): Homo sapiens (Human) 
2022-04-26 | PXD030129 | Pride
Bioid Mavs Bioid2 Bag6 
ProteomicsThe UIP honeycomb airways are defined by deranged ciliogenesis and elevated mucin biogenesis
Honeycombing (HC) is a histological pattern consistent with Usual Interstitial Pneumonia (UIP). HC refers to cystic airways (HC airways) located at sites of dense fibrosis with marked mucus accumulation. Utilizing laser capture microdissection coupled mass spectrometry (LCM-MS), we interrogate the f...
ORGANISM(S): Homo sapiens (Human) 
2025-03-25 | PXD036465 | Pride
Uip Human Laser capture Fibrosis Mucus Adenocarcinoma 
UnknownGrowth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone.
Not available
S-EPMC3224818 | biostudies-literature
UnknownUrinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.
Not available
S-EPMC2935914 | biostudies-literature
UnknownFatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke.
Not available
S-EPMC8055346 | biostudies-literature
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