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ProteomicsClass I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis
Outcomes for metastatic bone sarcomas, Ewing sarcoma and osteosarcoma, are dismal and remain unchanged for decades. Oxidative stress attenuates melanoma metastasis, and melanoma cells must reduce oxidative stress to metastasize. To explore this in sarcomas, we screened libraries of approved compound...
ORGANISM(S): Homo sapiens (Human) 
2019-10-28 | PXD014827 | Pride
Yb-1 Ms275 Sarcoma Hdac 
TranscriptomicsYarrowia lipolytica fed-batch biolipid production.
Time-course transcriptomic profilling of the oleaginous yeast Yarrowia lipolytica, during a controlled fed-batch. A nitrogen limitation was applied during the course of the fed-batch to initiate de novo biolipid synthesis. Dual staining, one replicate per slide. On each slide, a time point sample an...
ORGANISM(S): Yarrowia lipolytica 
2011-05-15 | E-GEOD-29046 | biostudies-arrayexpress
ProteomicsA comprehensive evaluation of the Ewing sarcoma surface and global proteomes reveals actionable immunotherapeutic targets.
Ewing sarcoma (EwS) is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. While the survival rate of patients diagnosed with localized disease is ~70%, this decreases to ~30% for patients with metastatic disease and only ~10% for treatment refractory d...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD043375 | Pride
Ewing sarcoma Surfaceome 
UnknownQuantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia.
Not available
S-EPMC5017887 | biostudies-literature
ProteomicsSurface and global proteome profiling of osteosarcoma patient derived xenografts
This study analyzed 22 unique OS patient-derived xenografts (PDXs) using proteomics to identify surface proteins for potential immunotherapeutic targeting. Plasma membranes were enriched using density gradient ultracentrifugation and compared to a reference standard of 12 immortalized non-OS cell li...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD075484 | Pride
Osteosarcoma 
ProteomicsIdentification of USP39 Ligands and Their Application in Targeted Protein Degradation
Alternative splicing is a tightly regulated process essential for transcriptomic and proteomic diversity, and its dysregulation has been implicated in various cancers. Ubiquitin-specific protease 39 (USP39) is a core component of the spliceosome that lacks enzymatic activity, rendering it challengin...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD065738 | Pride
Human Usp39 Protac 
ProteomicsSecretomics of ADAM17 and iRhom2 KO BV2 cells using high-performance secretome protein enrichment with click sugars
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is unknown. Another microglia-expressed AD ri...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-10 | PXD054894 | Pride
Mouse Bv2 Hispecs Timstof pro Adam17 Diapasef Microglia Irhom2 Secretome Rhbdf2 
ProteomicsInteractome of chromatin-associated RNA Polymerase II from U2OS cells
To determine the interactome of RNA Polymerase II (RNAPII), HA-tagged RPB3 was stably expressed in U2OS cells. The cells were harvested followed by the native stepwise isolation of chromatin-associated RNAPII complexes. HA-RPB3 was immunoprecipitated and interacting proteins analyzed by quantitative...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD054701 | Pride
Interactome U2os Rnapii 
ProteomicsProteomics of ADAM17 and iRhom2 KO microglia using high-performance secretome protein enrichment with click sugars
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is unknown. Another microglia-expressed AD ri...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-10 | PXD054898 | Pride
Mouse Hispecs Timstof pro Adam17 Diapasef Microglia Irhom2 Secretome Rhbdf2 
ProteomicsA MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma
MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) that predicts poor prognosis. However, whether genes within or in close proximity to the MYCN amplicon also contribute to aggressiveness in MNA+ NB remains poorly understood. Here we identify that GREB1, a transcription f...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039410 | Pride
Mycn Greb1 Myo1b Neuroblastoma Secretome 
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