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ProteomicsLyve-1 deficiency plasma proteomics
Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding hyaluronan, LYVE-1 mediates adhesion of leukocytes and cancer cells to endothelial cells. Here, we analyzed the impact of LYVE-1 on physiolog...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD032717 | Pride
Hepatic immune microenvironment Liver metastasis Lyve-1 Liver homeostasis Plasma 
ProteomicsMulti-facetted proteomics of mitochondrial TMBIM5 deficient cell lines: Regulation of mitochondrial proteostasis by the proton gradient
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multi-proteomic approach to demonstrate regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, couplin...
ORGANISM(S): Homo sapiens (Human) 
2022-07-26 | PXD030095 | Pride
Cyclohexamide Hek Mitochondria Ghitm Hela Silac Afg3l2 Tmbim5 
ProteomicsRibonucleotide synthesis by NME6 fuels mitochondrial gene expression
Replication and expression of the mitochondrial genome depend on the sufficient supply ofnucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental tomitochondrial genomes and can destabilise mitochondrial DNA and trigger inflammation. Here, wereport that a mitocho...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD038391 | Pride
Mitochondria Ribonucleotide Nme6 Rntps Lc-ms/ms 
ProteomicsQuantitative Proteomics of Mouse Liver (FTO-KO,WT) in response to DEN injection
Single nucleotide polymorphisms in the FTO gene encoding a m6A demthylase are associated with obesity and cancer development. However, the functional role of FTO in the developemnt of progression of hepatocellular carcinoma (HCC) as a proteotypic obesity-associated cancer remains unclear. Here, we h...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-03 | PXD018223 | Pride
Fto Den Cul4a Liver 
ProteomicsAIFM1 KO and AIFM1del mutant HEK cell proteomics
Mitochondrial proteases regulate the dynamic properties of the organelle morphology and ensure functional plasticity at the cellular level. The metalloprotease OMA1 mediates constitutive and stress-inducible processing of its substrates in mitochondria, but the number of functionally characterized s...
ORGANISM(S): Homo sapiens (Human) 
2026-01-31 | PXD063602 | Pride
Aifm1 Mitochondrion Hek 
ProteomicsLiver phosphoproteomics in response to AgRP activated neurons in the presence/absence of NPY
Autophagy represents a key regulator of aging and metabolism upon cell autonomous sensing of energy deprivation. We find that fasting in mice activates autophagy in liver paralleled by activation of hypothalamic AgRP neurons. Optogenetic and chemogenetic activation of AgRP neurons induces autophagy,...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-18 | PXD029247 | Pride
Phosphoproteomics Dia Liver Lc-ms/ms 
ProteomicsMitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7
Coenzyme Q (or ubiquinone) is a redox-active lipid, which serves as universal electron carrier in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid peroxidation and ferroptosis. Mechanisms allowing cellular coenzyme Q distribution after synthesis within mitoch...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-12 | PXD033064 | Pride
Mitochondria Stard7 Coq 
ProteomicsThe mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage
The metabolic plasticity of mitochondria supports cell development and differentiation and ensures cell survival under stress. The peptidase OMA1 regulates mitochondrial morphology and stress signaling and orchestrates tumorigenesis and cell fate decisions in a cell and tissue-specific manner. Here,...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-04 | PXD036595 | Pride
Mitochondria Dia Oma1 Mef 
ProteomicsWhole cell proteome of DNAJC15 short, uncleavable and wild type overexpression
Mitochondria dynamically adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limit mitochondrial fusion and promote mitochondrial stress signaling and metabolic rewiring. Here, we show that cellular stress a...
ORGANISM(S): Homo sapiens (Human) 
2026-01-20 | PXD072822 | Pride
Hela Dnajc15 Overexpression 
ProteomicsHeart proteome in Cox10 depending on Opa1 processing
Mitochondrial fusion and fission accompany adaptive responses to stress and altered metabolic demands. Inner membrane fusion and cristae morphogenesis depends on Optic Atrophy 1 (Opa1), which is expressed in different isoforms and is cleaved from a membrane-bound, long to a soluble, short form. Here...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD048804 | Pride
Heart Cox10 Opa1 
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