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ProteomicsHuman cell LC-MS shows phosphorylation sites of stathmin
HIV gp120-induced stathmin phosphorylation peptide sequences identified by mass spectrometry in the proteins immunoprecipitated from stathmin-GFP expressed cell lysates with the GFP-beads.
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023868 | Pride
Human Cell Lc-ms/ms 
ProteomicsNucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth
Hypoxia frequently occurs during rapid tumour growth. However, how tumour cells adapt to hypoxic stress by remodeling central cellular pathways remains largely unclear. Here, we demonstrated that hypoxia induces casein kinase 2 (CK2)-mediated glucokinase (GCK) S398 phosphorylation, which exposes its...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD061668 | Pride
Gck Tumorigenesis Taz Pin1 Hypoxia Phosphorylation 
ProteomicsBDNF stimulation of protein synthesis in cortical neurons requires the eIF4E kinase Mnk1
Although the Mnks have been known for >15 years, their roles in the regulation of protein synthesis have remained obscure. Here we explore how BDNF stimulates protein synthesis in cortical neurons. Using a combination of pharmacological and genetic approaches, we show that this effect depends on MEK...
ORGANISM(S): Mus musculus (Mouse) 
2014-11-06 | PXD001074 | Pride
Mnk1 Cortical neurons Boncat Mouse Fmrp Silac Bdnf Obitrap elite Eif4e 
ProteomicsCholine kinase promotes glycolysis and tumor growth by phosphorylating and activating enolase 1
Tumor cells exhibit aberrantly upregulated glycolysis, in which glycolytic enzyme enolase 1 (ENO1) plays a critical role. However, how ENO1 activity is dynamically regulated in tumor cells remains elusive. Here, we demonstrate that hypoxic stimulation promotes the binding of p38 MAP kinase to cholin...
ORGANISM(S): Acyrthosiphon pisum (Pea aphid) 
2026-09-05 | PXD058061 | Pride
ProteomicsCombined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes
Weill-Marchesani syndrome (WMS) is characterized by severe short stature, in particular short hands and feet (brachydactyly), joint contractures, tight skin, and heart valve, eye, and skin anomalies. Whereas recessive WMS is caused by mutations in ADAMTS10, ADAMTS17, or LTBP2 (all recessive), domina...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD068317 | Pride
Weill marchesani syndrome Adamts proteases Fibrillin Short stature syndromes Extracellular matrix 
Proteomics(Phospho)Proteomic Characterization of Ptenm3m4 Cortex
PTEN has a strong Mendelian association with autism spectrum disorder (ASD), representing a special case in autism’s complex genetic architecture. Animal modeling for constitutional Pten mutation creates an opportunity to study how disruption of Pten affects neurobiology and glean potential insight ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025351 | Pride
Lc-msms Autism Mouse Pten 
ProteomicsProtein S-Nitrosylation of host and viral proteins upon fibroblast infection with Human Cytomegalovirus
Human Cytomegalovirus (HCMV) is a ubiquitous pathogen that has co-evolved with its host and in doing so, is highly efficient in undermining antiviral responses that limit successful infections. As a result, HCMV infections are highly problematic in individuals with weakened or underdeveloped immune ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD019208 | Pride
Hcmv Protein s-nitrosylation Cytomegalovirus 
ProteomicsTargeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP to GTP exchange in the Gα subunit. This leads to dissociation of the heterotrimer into Gα-GTP and Gβγ dimer. The Gα-GTP and Gβγ dimer each regulate a variety of downstream pathways to control various aspects of...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-19 | PXD009503 | Pride
Lc-ms 
ProteomicsApolipoprotein F in hyperlipidemia
Apolipoprotein F (ApoF) modulates lipoprotein metabolism by selectively inhibiting cholesteryl ester transfer protein (CETP) activity on LDL. This ApoF activity requires that it is bound to LDL. How hyperlipidemia alters total plasma ApoF and its binding to LDL are poorly understood. In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD029713 | Pride
Hypercholesterolemia Plasma lipid transfer proteins Hypertriglyceridemia Apolipoproteins Ldl metabolism Lipid biochemistry Apolipoprotein f Cholesteryl ester transfer protein Lipoproteins 
ProteomicsIdentification of GFP-FIP200-interacting proteins
GFP or GFP-200 proteins were purified from the corresponding Flp-In™ T REx™ 293 cells using GFP-Trap beads. Purified proteins were analyzed by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2021-07-01 | PXD022563 | Pride
Fip200 Autophagy Tax1bp1 Sqstm1/p62 Tbk1 
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