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ProteomicsProtein Signatures to Distinguish Aggressive from Indolent Prostate Cancer
We performed a mass spectrometry-based proteomic analysis of normal and malignant prostate tissues from 22 men who underwent surgery for prostate cancer. Prostate cancer samples included Grade Groups (3 to 5), with 8 patients experiencing recurrence and 14 without evidence of recurrence with a mean ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD028118 | Pride
Ctsd Psa Prostate cancer Calr Postn Recurrent Yy1 Biomarker Prognosis 
ProteomicsYB-1 inhibition suppresses osteosarcoma growth and reverses tumor immunosuppression
U2OS, and SaOS cells were treated with DMSO (vehicle control) or SU056 (24h). Quantitative proteomics analysis was performed on cell lysates.
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD074439 | Pride
Yb-1 Osteosarcoma Cell lines Treatment 
ProteomicsFTO inhibition attenuates obstruction-induced kidney fibrosis by downregulating ferroptosis activator ACSL4 and profibrotic factor TGFBI
Analysis by LC-MS/MS shotgun proteomics was performed on lysates from the following samples: 1) Control HK2 cells generated using control CRISPR/CAS9 system and scrambled guide RNA (sgRNAGCACTCACATCGCTACATCA) 2) HK2 cells with FTO knockout using CRISPR/Cas9 system and target 2 guide RNA (sgCCTACAAGT...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD051362 | Pride
Hk2 Ferroptosis Kidney fibrosis Fto 
ProteomicsY Box Binding Protein 1 Inhibition as a Targeted Therapy for Ovarian Cancer
A azopodophyllotoxin small molecule, SU056, was identified as a novel inhibitor of Y Box Binding Protein 1 and may inhibit progression of ovarian cancer.
ORGANISM(S): Homo sapiens (Human) 
2021-12-19 | PXD022332 | Pride
Therapeutics Ovarian cancer Human 
ProteomicsProteomic Analysis of Umbilical Cord and Adult Mesenchymal Stem Cells
Shotgun proteomic analysis was performed on lysates from umbilical cord and adjult mesenchymal stem cells
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD032994 | Pride
Lc-ms/ms Proteomics Stem cells 
ProteomicsQuantitative proteomic profiling reveals key pathways in the anti-cancer action of methoxychalcone derivatives in triple negative breast cancer
Synthetic analogues of chalcones were investigated as potential therapeutics for triple negative breast cancer. These analogues were used in quantitative proteomic experiments to determine the mechanism of action.
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD009553 | Pride
Breast cancer Cancer Drugs Cell lines Human 
ProteomicsOncogene-Mediated Metabolic Gene Signature Predicts Breast Cancer Outcome
We performed shotgun protoemic analysis of tumor samples from HCC1806 shCtrl and shTrop2 xenograft mice.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-19 | PXD028335 | Pride
Proteomics Trop2 Breast cancer 
ProteomicsProteomic analysis of LNCaP wildtype (WT) and LNCaP OR51E2-knock out xenograft mouse tumor tissue
Quantitative proteomic analysis of tumor tissue lysates from wildtype LNCaP (WT) and LNCaP OR51E2-/- (KO) xenografts in male CIEA NOG mice.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-03-26 | PXD055974 | Pride
Or51e2  prostate cancer  stat3  xenograft. 
ProteomicsIdentification of a 5-gene Signature Panel for the Prediction of Prostate Cancer Progression
Quantitative proteomics analysis was performed on two samples of localized prostate tumors from one patient (R40) and eight samples from metastatic prostate cancer sites. One sample from the right lung, one sample from the peritoneal lymph node, and two samples from the mediastinal lymph node were c...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD056300 | Pride
Prognosis  progression  prostate cancer  metastasis 
ProteomicsProteomics Analysis of Trop2 Xenograft Prostate Tumors
Shotgun proteomic analysis of LNCaP-Trop2-OV tumor xenografts and LNCaP-RFP control tumors
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-05 | PXD039272 | Pride
Prostate cancer Trop2 Xenograft Mice 
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