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ProteomicsProtein Signatures to Distinguish Aggressive from Indolent Prostate Cancer
We performed a mass spectrometry-based proteomic analysis of normal and malignant prostate tissues from 22 men who underwent surgery for prostate cancer. Prostate cancer samples included Grade Groups (3 to 5), with 8 patients experiencing recurrence and 14 without evidence of recurrence with a mean ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD028118 | Pride
Ctsd Psa Prostate cancer Calr Postn Recurrent Yy1 Biomarker Prognosis 
ProteomicsNon-allosteric Inhibition of Enolase 1 Impedes Growth of Triple-Negative Breast Cancer
1. Cellular Thermal Shift Assay (CETSA): MDA-MB-231 cells were treated for 6h with DMSO or SU212 and incubated at different temperatures and protein differences in the soluble fractions were determined. 2. Quantitative Proteomics: MDA-MB-231, MDA-MB-468, and BT549 cells were treated with DMSO (vehi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-10 | PXD061466 | Pride
Non-allosteric inhibition Eno1 Aza-podophyllotoxin derivative Enolase Triple-negative breast cancer 
ProteomicsYB-1 inhibition suppresses osteosarcoma growth and reverses tumor immunosuppression
U2OS, and SaOS cells were treated with DMSO (vehicle control) or SU056 (24h). Quantitative proteomics analysis was performed on cell lysates.
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD074439 | Pride
Yb-1 Osteosarcoma Cell lines Treatment 
ProteomicsFTO inhibition attenuates obstruction-induced kidney fibrosis by downregulating ferroptosis activator ACSL4 and profibrotic factor TGFBI
Analysis by LC-MS/MS shotgun proteomics was performed on lysates from the following samples: 1) Control HK2 cells generated using control CRISPR/CAS9 system and scrambled guide RNA (sgRNAGCACTCACATCGCTACATCA) 2) HK2 cells with FTO knockout using CRISPR/Cas9 system and target 2 guide RNA (sgCCTACAAGT...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD051362 | Pride
Hk2 Ferroptosis Kidney fibrosis Fto 
ProteomicsProteomics of Triple Negative Breast Cancer Cells Treated with SU056
1. Quantitative Proteomics: MDA-MB-231, MDA-MB-468, and MCF12A cells were treated with DMSO (vehicle control) or SU056 (novel small molecule drug candidate). Quantitative proteomics analysis was performed on cell lysates. 2. Cellular Thermal Shift Assay (CETSA): MDA-MB-231 cells were treated with D...
ORGANISM(S): Homo sapiens (Human) 
2024-04-04 | PXD042380 | Pride
Breast cancer Cell lines Triple negative Treatment 
ProteomicsY Box Binding Protein 1 Inhibition as a Targeted Therapy for Ovarian Cancer
A azopodophyllotoxin small molecule, SU056, was identified as a novel inhibitor of Y Box Binding Protein 1 and may inhibit progression of ovarian cancer.
ORGANISM(S): Homo sapiens (Human) 
2021-12-19 | PXD022332 | Pride
Therapeutics Ovarian cancer Human 
ProteomicsQuantitative proteomic profiling reveals key pathways in the anti-cancer action of methoxychalcone derivatives in triple negative breast cancer
Synthetic analogues of chalcones were investigated as potential therapeutics for triple negative breast cancer. These analogues were used in quantitative proteomic experiments to determine the mechanism of action.
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD009553 | Pride
Breast cancer Cancer Drugs Cell lines Human 
ProteomicsProteomic Analysis of Umbilical Cord and Adult Mesenchymal Stem Cells
Shotgun proteomic analysis was performed on lysates from umbilical cord and adjult mesenchymal stem cells
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD032994 | Pride
Lc-ms/ms Proteomics Stem cells 
ProteomicsUCHL1 is a Molecular Indicator and a Therapeutic Target for Neuroendocrine Carcinomas
Quantitative proteomics analysis was performed on patient derived neuroendocrine tissue xenografts comparing sh control (N=2), and shUCHL1 (N=4), and in NCI-H660 cell line xenografts comparing control (N=3) and LDN-57444 treated (N=3). Each condition was injected in triplicate.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-12-03 | PXD044864 | Pride
Uchl1 Xenografts Prostate cancer Neuroendocrine carcinomas 
ProteomicsOncogene-Mediated Metabolic Gene Signature Predicts Breast Cancer Outcome
We performed shotgun protoemic analysis of tumor samples from HCC1806 shCtrl and shTrop2 xenograft mice.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-19 | PXD028335 | Pride
Proteomics Trop2 Breast cancer 
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