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ProteomicsBRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation
BRCA1/BARD1 is a tumor suppressor E3 ubiquitin (Ub) ligase with roles in DNA damage repair and in transcriptional regulation. BRCA1/BARD1 RING domains interact with nucleosomes to facilitate mono-ubiquitylation of distinct residues on the C-terminal tail of histone H2A. These enzymatic domains const...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD035345 | Pride
Kojak Brca1 Cancer Nucleosome Cross-linking mass spectrometry Proxl H2a Xl-ms Bard1 Tumor Ubiquitin ligase 
ProteomicsCullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain
RING-Between-RING (RBR) E3 ligases mediate ubiquitin transfer through an obligate E3- ubiquitin thioester intermediately prior to substrate ubiquitination. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic and the relevant domains have yet to be identi...
ORGANISM(S): Homo sapiens (Human) 
2023-05-24 | PXD030849 | Pride
Kojak Cross-linking mass spectrometry Proxl Skyline Cullin Xl-ms Hhari Ubiquitin Rbr E3 ligase 
ProteomicsDiscovery and visualization of uncharacterized drug-protein adducts using mass spectrometry
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-02-24 | PXD025019 | Pride
Magnum Raloxifene Dicloxacillin Adduct Plasma Cyp3a4 Open search Metamorpheus Comet Human serum albumin Msfragger Penicillin Moda Hsa Xenobiotic Reactive metabolite P450-reductase Flucloxacillin Open-pfind Comet-ptm Limelight 
ProteomicsThe kinesin motor Kif9 regulates centriolar satellite positioning during interphase
Centrosomes are the principal microtubule-organizing centers of the cell, a cellular hub for protein degradation and play an essential role in mitotic spindle function that ultimately regulates chromosome segregation during mitosis. Centrosome maturation is achieved by strict control of protein acqu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD048536 | Pride
Centrosome Chromosome segregation Mitosis Kif9 Microtubule-organizing center Lc-msms Gfp 
ProteomicsQuantitative XL-MS Analysis of HHARI in the presence or absence of 4EHP
RING-Between-RING (RBR) E3 ligases mediate ubiquitin transfer through an obligate E3- ubiquitin thioester intermediately prior to substrate ubiquitination. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic and the relevant domains have yet to be identi...
ORGANISM(S): Homo Sapiens 
PXD030871 | panorama
ProteomicsProteomic profiling of human omental and subcutaneous adipose tissue in individuals with a broad range of BMI
Obesity is a major public health challenge affecting an ever-increasing proportion of the global population. It is associated with numerous comorbidities. Progressive expansion and remodeling of adipose tissue may lead to depot specific changes in adipose tissue biology and energy partitioning. Such...
ORGANISM(S): Homo Sapiens 
2026-03-07 | PXD067514 | panorama
ProteomicsQuantification of Raloxifene Specific 471 Da Adducts in CYP3A4 and P450-Reductase
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit critical proteins, elicit immune responses, and cause life threatening adverse drug reactions. The masses of metabolites are frequently unknown, rendering traditional mass spectrometry-based proteomi...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2022-02-21 | PXD024932 | panorama
ProteomicsDetection and Quantification of Drug-Protein Adducts in Human Liver
Protein adducts formed by drugs or their reactive metabolites are risk factors for adverse reactions, toxicity and inactivation of cytochrome P450 (CYP) enzymes. Characterization of drug-protein adducts is limited due to lack of methods capable of discovering the proteins and peptides adducted by re...
ORGANISM(S): Homo Sapiens Spodoptera Frugiperda 
PXD054246 | panorama
ProteomicsThe molecular basis of integrated stress response silencing
Chronic stress response activation impairs cell survival and causes devastating degenerative di-seases. To counteract this, cells deploy dedicated silencing factors, such as the E3 ligase SIFI that terminates the mitochondrial stress response. How a single enzyme can sense stress across cellular sca...
ORGANISM(S): Homo sapiens (Human) 
2025-04-16 | PXD055759 | Pride
Sifi Xl-ms Mass spectrometry Ubiquitin E3 ligase Bs3 
ProteomicsDevelopment and Validation of a Novel LC-MS/MS Based Proteomics Method for Quantitation of Retinol Binding Protein 4 (RBP4) and Transthyretin (TTR)
Retinol binding protein 4 (RBP4) is the plasma carrier of retinol that complexes with transthyretin (TTR). A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous absolute quantitation of serum and plasma RBP4 and TTR is needed to advance the understanding of RBP4 and TT...
ORGANISM(S): Homo Sapiens 
PXD061072 | panorama
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