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ProteomicsProteomics of preclinical model of skin dermatitis
To assess the preclinical Aldara model, the proteomic response of mouse skin to topical applied Aldara cream was assessed using untargeted LC-MS. Skin from sham treated or treated with the Aldara cream were compared for 4 independent experiments after 8 days of treatment.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD056245 | Pride
Mouse Orbitrap qe-hf-x Skin 
ProteomicsSystems pharmacology dissection of cholesterol regulation reveals determinants of large pharmacodynamic variability between cell lines
In individuals, heterogeneous drug response phenotypes result from a complex interplay of dose, drug specificity, genetic background, and environmental factors, thus challenging our understanding of the underlying processes and optimal use of drugs in the clinic. Here, we use mass spectrometry-based...
ORGANISM(S): Homo sapiens (Human) 
2017-12-07 | PXD005955 | Pride
Cholesterol regulation T0901317 Cholesterol homeostasis Hela kyoto Gw3965 Srebp Lxr Hek293 Atorvastatin Srebp1 Srebp2 Npc1 Ldlr Huh7 Hmgcs1 Hepg2 
ProteomicsDemonstration of increased biologically active CXCL12α plasma concentrations after ACKR3 antagonist treatment in humans
CXCL12 is a chemokine that binds to its cognate receptors CXCR4 and ACKR3 (CXCR7). An increase in CXCL12 concentrations has been used as a pharmacodynamic biomarker to assess ACKR3 antagonism in healthy adults. Furthermore, increased CXCL12 concentrations have been observed in various human patholog...
ORGANISM(S): Homo sapiens (Human) 
2024-01-27 | PXD038814 | Pride
Plasma Ia-ms Biomarker 
ProteomicsQuantification of brain, muscle, and liver using large SWATH-spectral library
Sequential window acquisition of all theoretical mass spectra (SWATH-MS) requires a spectral library to extract quantitative measurements from the mass spectrometry data acquired in data-independent acquisition mode (DIA). Large combined spectral libraries containing SWATH assays have been generated...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-12-18 | PXD010869 | Pride
Brain Liver Zebrafish Muscle 
ProteomicsZebrafish SWATH-MS spectral library to quantify 10,000 proteins
Sequential window acquisition of all theoretical mass spectra (SWATH-MS) requires a spectral library to extract quantitative measurements from the mass spectrometry data acquired in data-independent acquisition mode (DIA). Large combined spectral libraries containing SWATH assays have been generated...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-12-18 | PXD010876 | Pride
Eye Intestine Heart Brain Liver Zebrafish Ovaries Spleen Testes Muscle 
ProteomicsBTLA interacting proteins in mouse CD4+ effector T cells - Part2
Identifying BTLA interacting proteins in mouse CD4+ effector T cells expressing BTLA at endogenous levels and after stimulation with pervanadate.
ORGANISM(S): Mus musculus (Mouse) 
2019-05-06 | PXD010863 | Pride
Mouse Btla T cells 
ProteomicsPD-1 interacting proteins in Jurkat cells stimulated with Raji cells and SEE - Part3
Identifying PD-1 interacting proteins in Jurkat cells expressing PD-1 after stimulation with Raji cells and the superantigen SEE.
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD010864 | Pride
Human Pd-1 T-cells Pdcd1 
ProteomicsPD-1 interacting proteins - Part1
Identifying PD-1 interacting proteins in mouse CD4+ effector T cells expressing PD-1 at endogenous levels and after stimulation with pervanadate.
ORGANISM(S): Mus musculus (Mouse) 
2019-05-06 | PXD010862 | Pride
Pd-1 Mouse T-cells Pdcd1 
ProteomicsPD-1 interacting proteins in SILAC labelled Jurkat cells stimulated with Raji cells - Part4
Identifying PD-1 interacting proteins in Jurkat cells expressing PD-1 after stimulation with Raji cells and the superantigen SEE.
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD013531 | Pride
Pd-1 Thermo fusion lumos T cells 
Proteomics113 DLBCL SWATH maps by PCT-SWATH
Rapid proteotyping of 41 FFPE DLBCL tumor tissues with 2-3 biological replicates using pressure-cycling technology (PCT) and SWATH mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2019-10-07 | PXD014943 | Pride
Pct-dia Swath Ffpe Dlbcl 
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