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ProteomicsEndogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis
Androgen receptor (AR) is a key player in prostate cancer development and progression. Here we applied immunoprecipitation mass spectrometry of endogenous AR in LNCaP cells to identify components of the AR transcriptional complex. In total, 66 known and novel AR interactors were identified in the pr...
ORGANISM(S): Homo sapiens (Human) 
2017-10-27 | PXD008056 | Pride
Prostate cancer Interactome Rime Proteomics Androgen receptor 
ProteomicsMAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
MAD2L2 (also known as REV7) functions in a diverse range of processes. It facilitates DNA lesion bypass through translesion synthesis (TLS), aids in interstrand crosslink repair and contributes to timely mitotic progression. Moreover, MAD2L2 plays an important role in DNA repair at DNA double strand...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD026912 | Pride
Mad2l2 Trip13 Dna repair Shieldin Nhej 
ProteomicsLoss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance
The presentation of peptides on HLA molecules is essential to CD8+ T cell responses. Here, we show that loss of uL14 significantly downregulates the expression of antigen processing and presentation (APP) components in melanoma cell lines. Peptides generated following knock down show different chara...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059093 | Pride
Lc-ms/ms Ribosome  ul14  antigen presentation 
ProteomicsPAXIP1 and STAG2 converge to maintain 3D genome archi-tecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
How steroid hormone receptors (SHRs) orchestrate transcriptional activity remains only partly understood. Upon activation, SHRs bind the genome and recruit their co-regulators, crucial to induce gene expression. However, it remains unknown which components of the SHR-recruited coregulator complex ar...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038902 | Pride
Lc-msms  paxip1  stag2  rime glucocorticoid receptor 
ProteomicsGlucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer
The glucocorticoid receptor (GR) regulates gene expression throughout the human genome in a cell-type-specific manner, governing various aspects of homeostasis. The influence of this transcriptional regulator is seen in multiple pathologies, including cancer. Pharmacological activation of the GR is ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-17 | PXD021924 | Pride
Human Lc-msms Glucocorticoid receptor Rime Lfq Protein p57 Cdkn1c Lung cancer Proteome Phosphoproteome 
ProteomicsDrug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence
In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various stages of the disease. However, therapy resistance inevitably occurs and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multi-omics analyses on tissues isol...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032041 | Pride
Foxa1 Prostate cancer Androgen receptor(ar) Enzalutamide Lc-msms Arntl 
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