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ProteomicsEndogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis
Androgen receptor (AR) is a key player in prostate cancer development and progression. Here we applied immunoprecipitation mass spectrometry of endogenous AR in LNCaP cells to identify components of the AR transcriptional complex. In total, 66 known and novel AR interactors were identified in the pr...
ORGANISM(S): Homo sapiens (Human) 
2017-10-27 | PXD008056 | Pride
Prostate cancer Interactome Rime Proteomics Androgen receptor 
ProteomicsTRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination
The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number of interacting proteins, many AR coregulators remain to be characterized in relation to their disti...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD058914 | Pride
Ar Trim33 Rime Lc-msms 
ProteomicsMAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
MAD2L2 (also known as REV7) functions in a diverse range of processes. It facilitates DNA lesion bypass through translesion synthesis (TLS), aids in interstrand crosslink repair and contributes to timely mitotic progression. Moreover, MAD2L2 plays an important role in DNA repair at DNA double strand...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD026912 | Pride
Mad2l2 Trip13 Dna repair Shieldin Nhej 
ProteomicsThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. Here we show that this cohesin acetylation cycle contr...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD032185 | Pride
Cohesin acetylation cycle Ctcf Esco1 Pds5a Cohesin Hdac8 3d genome Wapl Chromatin loops Pds5b 
ProteomicsLoss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance
The presentation of peptides on HLA molecules is essential to CD8+ T cell responses. Here, we show that loss of uL14 significantly downregulates the expression of antigen processing and presentation (APP) components in melanoma cell lines. Peptides generated following knock down show different chara...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059093 | Pride
Lc-ms/ms Ribosome  ul14  antigen presentation 
ProteomicsRibosome impairment regulates intestinal stem cell identity via ZAKa activation.
The small intestine is a rapidly proliferating organ that is maintained by a small population of Lgr5-expressing intestinal stem cells (ISCs). However, several Lgr5-negative ISC populations have been identified, and this remarkable plasticity allows the intestine to rapidly respond to both the local...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-13 | PXD033122 | Pride
Zaka Proteomics Lc-msms Intestinal stem cells 
ProteomicsBreast cancer identity is determined by glucocorticoid receptor activity status
Glucocorticoid receptor (GR) is a ligand-inducible transcription factor with an intricate role in cancer biology. Using an in silico designed GR activity signature we show that GR is a tumor suppressor across diverse primary cancers. In breast cancer, GR activity status determines luminal identity, ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-02 | PXD039209 | Pride
Human Lc-msms Breast cancer Glucocorticoid receptor gr Estrogen receptor-alpha (er) Zbtb16 
ProteomicsUBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168
Maintenance of genome integrity requires tight control of DNA damage signalling and repair activities at DNA lesions, as well as their restriction at telomeres. Key components of the mechanisms underlying appropriate responses to DNA damage include phosphorylation events by DNA damage response (DDR)...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-30 | PXD044410 | Pride
Molecular biology Non-homologous-end joining Rnf168 Dna damage and repair Ube2d3 Lc-msms Telomere 
ProteomicsMYC is a clinically significant determinant of mTOR inhibitor resistance in breast cancer
Targeting the PI3K-AKT-mTOR pathway is a promising therapeutic strategy for breast cancer treatment. However, low response rates and the development of acquired resistance to PI3K-AKT-mTOR inhibitors remain major challenges for successful patient treatment. Here, we show that MYC activation is a cen...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-02 | PXD041927 | Pride
Azd8055 Pi3k-akt-mtor signaling pathway Myc Tumor Mtori Lc-msms Mouse invasive lobular carcinoma Ilc 
ProteomicsPAXIP1 and STAG2 converge to maintain 3D genome archi-tecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
How steroid hormone receptors (SHRs) orchestrate transcriptional activity remains only partly understood. Upon activation, SHRs bind the genome and recruit their co-regulators, crucial to induce gene expression. However, it remains unknown which components of the SHR-recruited coregulator complex ar...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038902 | Pride
Lc-msms  paxip1  stag2  rime glucocorticoid receptor 
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