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ProteomicsProteomics on Nav1.8-positive nociceptors of mouse DRG
Nociceptors play an essential role in both acute pain and chronic pain conditions. In this study, we examined the proteome of mouse dorsal root ganglia and compared NaV1.8Cre+/-; ROSA26-flox-stop-flox-DTA (Diphtheria toxin fragment A) mutant mice (NaV1.8Cre-DTA), in which NaV1.8-positive neurons (ma...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-03 | PXD034447 | Pride
Proteomics Mouse drg Ms Nociception 
ProteomicsDeep Proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice
The age and sex of studied animals profoundly impacts experimental outcomes in animal-based biomedical research. However, most preclinical studies in mice use a wide-spanning age range from 4 to 14 weeks and do not assess study parameters in male and female mice in parallel. This raises concerns reg...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD034476 | Pride
Mouse Dia-pasef Skin Sex Sciatic nerve Proteome Age 
ProteomicsDIA LC-MS analysis of post-incisional human and mouse skin biopsies
Acute postsurgerical pain and it's management represent a major clinical challenge. In particular, severe and prolonged pain impairs immediate recovery and might lead to long-term consequences like chronic pain, opioid abuse, and reduced quality of life. Rodent incision models greatly contributed ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-03-07 | PXD030828 | Pride
Pain Bi-translational Lc-ms Incision Human Cutaneous protein signatures Mouse Hf-x 
ProteomicsRat DRG CIPN versus Vehicle-treatment_DIA-MS
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of cancer treatment, often leading to cessation of therapy due to lack of adequate treatment options. In the peripheral nervous system the chemotherapeutic agent paclitaxel impairs mitochondrial function and induces vast chan...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-03-24 | PXD028356 | Pride
Rat Dia-ms Drg-proteome Cipn Hf-x 
ProteomicsMouse DRG incision injury versus sham_DIA-MS
Acute pain after surgery is still managed insufficiently. One major need is, therefore, the identification of new targets specifically relevant for postoperative pain to develop effective and non-addictive analgesics. To this end, we have used the plantar incision model in male mice and DIA-MS to re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022706 | Pride
Pain Dia-ms Drg Incision injury 
ProteomicsBulk proteomics of naive human dorsal root ganglion
Study Purpose: This study set out to a) provide a quantitative proteomic reference for the human DRG and nerve root and b) explore sexual dimorphism in these tissues. Data Collection: DIA-PASEF proteomics was performed on hDRG tissue from donors. Primary Conclusion: Multi-omic integration with hum...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD061129 | Pride
Dia-pasef Proteomics Dorsal root ganglia Drg Dia Sensory neurons 
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
ProteomicsDemographic variables shape longitudinal proteome signatures of peripheral nerve injury in mice
Our comprehensive proteomic analysis of mouse sciatic nerves following Spared Nerve Injury (SNI) reveals new dimensions of the molecular mechanisms underlying peripheral nerve injury, shaped by sex, developmental stage, and progression over time. Building on our previous work profiling naïve sciatic...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-05 | PXD067006 | Pride
Sex-dependent Proteomics Peripheral nerve injury Age-dependent 
ProteomicsA sub-compartment proteome for murine sensory neurons
We applied TurboID-based proximity labelling restricted to Advillin-expressing neurons to systematically profile the proteomes of distinct neuronal subcompartments, using parallel accumulation–serial fragmentation combined with data-independent acquisition (diaPASEF) mass spectrometry. Neuronal comp...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-14 | PXD062198 | Pride
Sensory neuron Dia-ms Dorsal root ganglia Pns Turboid 
ProteomicsDeep proteome profiling of dorsal root ganglia after nerve injury deciphers shared signatures in adolescent and adult male and female mice
Our understanding of how sex and age influence pathological pain at the molecular level is still limited. This is of high relevance for pediatric and adolescent patients, as they are known to be particularly vulnerable to long-term consequences of pathological pain. Here, we leveraged deep proteome ...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-19 | PXD055816 | Pride
Pediatric Neuropathic pain Proteomics Chronic pain Mefisto Peripheral nervous system Sex similarities Nerve injury Dorsal root ganglia Proteome 
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